Pre_GI: BLASTP Hits

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Query: NC_009698:3526359:3537387 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3537387, End: 3537596, Length: 210

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:3752000:376573537657353765944210Clostridium botulinum F str. 230613 chromosome, complete genomeputative 2-oxoacid:acceptor oxidoreductase subunit delta9e-33138
NC_012658:3744000:375520537552053755414210Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative 2-oxoacid:acceptor oxidoreductase subunit delta9e-33138
NC_009699:3753599:376712137671213767330210Clostridium botulinum F str. Langeland chromosome, complete genome2-oxoacid:acceptor oxidoreductase subunit delta9e-33138
NC_009697:3629250:364027836402783640487210Clostridium botulinum A str. ATCC 19397 chromosome, complete2-oxoacid:acceptor oxidoreductase subunit delta9e-33138
NC_010516:3724312:373534237353423735551210Clostridium botulinum B1 str. Okra, complete genomeputative 2-oxoacid:acceptor oxidoreductase, delta subunit9e-33138
NC_010520:3753875:376485637648563765065210Clostridium botulinum A3 str. Loch Maree, complete genomeputative 2-oxoacid:acceptor oxidoreductase, delta subunit9e-33138
NC_012563:3921859:393219339321933932402210Clostridium botulinum A2 str. Kyoto, complete genomeputative 2-oxoacid:acceptor oxidoreductase, delta subunit9e-33138
NC_014538:1942500:195050519505051950717213Thermoanaerobacter sp. X513 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur-binding domain-containing protein7e-1475.9
NC_013316:120759:154477154477154692216Clostridium difficile R20291, complete genomeferredoxin7e-1475.9
NC_009089:117980:158967158967159182216Clostridium difficile 630, complete genomeferredoxin7e-1475.9
NC_015958:2206032:223108922310892231301213Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-1374.3
NC_016629:1175828:119452311945231194771249Desulfovibrio africanus str. Walvis Bay chromosome, complete4Fe-4S ferredoxin3e-1270.5
NC_011769:2542000:254703525470352547274240Desulfovibrio vulgaris str. 'Miyazaki F', complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein5e-1269.7
NC_015555:386000:393611393611393841231Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-1167.4
NC_007503:1111457:116682011668201167038219Carboxydothermus hydrogenoformans Z-2901, complete genomeputative keto/oxoacid ferredoxin oxidoreductase, delta subunit3e-1167.4
NC_016751:142237:152906152906153136231Marinitoga piezophila KA3 chromosome, complete genomedissimilatory sulfite reductase subunit alpha/beta4e-1167
NC_009616:99647:107251107251107472222Thermosipho melanesiensis BI429 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein4e-1167
NC_011653:331986:340827340827341048222Thermosipho africanus TCF52B, complete genomehypothetical protein1e-1065.1
NC_014632:11925:284742847428689216Ilyobacter polytropus DSM 2926 chromosome, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit delta1e-1065.1
NC_014614:1309203:131317013131701313409240Clostridium sticklandii, complete genome4Fe-4S ferredoxin, iron-sulfur binding domain protein2e-1064.3
NC_010003:1577934:158898915889891589222234Petrotoga mobilis SJ95, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein5e-1063.2
NC_002939:2008304:203955820395582039761204Geobacter sulfurreducens PCA, complete genomeketo/oxoacid ferredoxin oxidoreductase subunit9e-0958.9
NC_010337:1188373:119572611957261195998273Heliobacterium modesticaldum Ice1, complete genome2-oxoacid:ferredoxin oxidoreductase, delta subunit, putative4e-0857
NC_015499:352934:367809367809368033225Thermodesulfobium narugense DSM 14796 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein1e-0755.5
NC_005791:1626448:162901816290181629224207Methanococcus maripaludis S2, complete genome2-oxoglutarate ferredoxin oxidoreductase, delta (ferredoxin) subunit7e-0752.8
NC_009975:917337:933216933216933422207Methanococcus maripaludis C6, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein7e-0752.8
NC_015847:1712023:171458217145821714788207Methanococcus maripaludis XI chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein7e-0752.8
NC_009135:1654131:167045816704581670664207Methanococcus maripaludis C5, complete genome4Fe-4S ferredoxin, iron-sulfur binding domain protein7e-0752.8
NC_015562:1413264:141555214155521415746195Methanotorris igneus Kol 5 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein7e-0752.8
NC_014011:813645:831568831568831777210Aminobacterium colombiense DSM 12261 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-0652
NC_009637:920423:923514923514923720207Methanococcus maripaludis C7 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein1e-0652
NC_013522:991649:101250410125041012713210Thermanaerovibrio acidaminovorans DSM 6589, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein3e-0650.8
NC_014222:1411155:142703514270351427238204Methanococcus voltae A3 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein3e-0650.8