Pre_GI: BLASTP Hits

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Query: NC_009698:3526359:3532210 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3532210, End: 3533181, Length: 972

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:3629250:363510136351013636072972Clostridium botulinum A str. ATCC 19397 chromosome, completeglucitol operon regulator0657
NC_012563:3921859:392701539270153927986972Clostridium botulinum A2 str. Kyoto, complete genomeputative glucitol operon regulator0654
NC_010516:3724312:373016437301643731135972Clostridium botulinum B1 str. Okra, complete genomeputative glucitol operon regulator0654
NC_010520:3753875:375967837596783760649972Clostridium botulinum A3 str. Loch Maree, complete genomeputative glucitol operon regulator0654
NC_012658:3744000:375002637500263750997972Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative glucitol operon regulator0652
NC_009699:3753599:376194337619433762914972Clostridium botulinum F str. Langeland chromosome, complete genomeglucitol operon regulator0645
NC_017297:3752000:376055637605563761527972Clostridium botulinum F str. 230613 chromosome, complete genomeputative glucitol operon regulator0645
NC_014377:1400544:140441214044121405368957Thermosediminibacter oceani DSM 16646 chromosome, complete genometranscriptional regulator, DeoR family5e-59228
NC_015519:686027:687874687874688818945Tepidanaerobacter sp. Re1 chromosome, complete genomeDeoR family transcriptional regulator2e-53209
NC_002570:832480:844531844531845481951Bacillus halodurans C-125, complete genometranscriptional regulator2e-53209
NC_013199:392450:409023409023409970948Lactobacillus rhamnosus Lc 705, complete genometranscriptional regulator, SorR, sorbitol operon regulator9e-50197
NC_013517:3997448:400404740040474005012966Sebaldella termitidis ATCC 33386, complete genometranscriptional regulator, DeoR family7e-48191
NC_013501:777947:786311786311787264954Rhodothermus marinus DSM 4252, complete genometranscriptional regulator, DeoR family8e-46184
NC_014624:551510:564192564192565154963Eubacterium limosum KIST612 chromosome, complete genomeDeoR family transcriptional regulator6e-44178
NC_006270:4048876:406533340653334066271939Bacillus licheniformis ATCC 14580, complete genometranscriptional regulator6e-42171
NC_006322:4048990:406544740654474066385939Bacillus licheniformis ATCC 14580, complete genomeDeoR6e-42171
NC_015588:1847500:186918818691881870168981Isoptericola variabilis 225 chromosome, complete genometranscriptional regulator, DeoR family1e-39164
NC_014532:3479674:349149834914983492457960Halomonas elongata DSM 2581, complete genomeK05346 deoxyribonucleoside regulator8e-38157
NC_006370:768745:787608787608788588981Photobacterium profundum SS9 chromosome 1, complete sequenceputative transcriptional regulator, SorC family2e-34146
NC_021064:1789980:179671917967191797663945Propionibacterium avidum 44067, complete genometranscriptional regulator deoR family protein4e-34145
NC_019973:1731626:175707817570781757983906Mesorhizobium australicum WSM2073, complete genometranscriptional regulator with sigma factor-related N-terminal domain2e-33143
NC_014364:3707311:371045937104593711397939Spirochaeta smaragdinae DSM 11293 chromosome, complete genometranscriptional regulator, DeoR family4e-33142
NC_009655:195500:208793208793209746954Actinobacillus succinogenes 130Z chromosome, complete genomeDeoR family transcriptional regulator3e-33142
NC_015519:426948:468217468217469179963Tepidanaerobacter sp. Re1 chromosome, complete genomeDeoR family transcriptional regulator5e-33141
NC_011740:1595381:159716515971651598118954Escherichia fergusonii ATCC 35469, complete genomeDNA-binding transcriptional regulator1e-32140
NC_016816:2782373:280522428052242806171948Pantoea ananatis LMG 5342, complete genomedeoxyribonucleoside regulator DeoR7e-31134
NC_012962:1661683:1661683166168316626901008Photorhabdus asymbiotica, complete genomeputative transcriptional regulator, sorc family (putative sorc-typ transcriptional regulator)1e-30134
NC_013517:3948500:396115939611593962091933Sebaldella termitidis ATCC 33386, complete genometranscriptional regulator, DeoR family1e-30134
NC_015519:270637:290221290221291177957Tepidanaerobacter sp. Re1 chromosome, complete genomeDeoR family transcriptional regulator2e-30133
NC_014364:815346:841673841673842638966Spirochaeta smaragdinae DSM 11293 chromosome, complete genometranscriptional regulator, DeoR family2e-30132
NC_015675:1721543:174709817470981748003906Mesorhizobium opportunistum WSM2075 chromosome, complete genomeDeoR family transcriptional regulator5e-30132
NC_014923:1680095:170472417047241705704981Mesorhizobium ciceri biovar biserrulae WSM1271 chromosome, completesugar-binding domain-containing protein9e-30130
NC_012704:1641684:165346716534671654402936Corynebacterium kroppenstedtii DSM 44385, complete genometranscriptional regulator, DeoR family2e-29129
NC_006155:652500:6527396527396537521014Yersinia pseudotuberculosis IP 32953, complete genomeputative transcriptional repressor1e-27124
NC_010634:635362:635362635362636357996Yersinia pseudotuberculosis PB1/+, complete genomeDeoR family transcriptional regulator1e-27124
NC_012032:1827244:184394718439471844870924Chloroflexus sp. Y-400-fl, complete genometranscriptional regulator, DeoR family2e-26119
NC_010175:1825878:184258118425811843504924Chloroflexus aurantiacus J-10-fl, complete genomeputative sugar-binding domain protein2e-26119
NC_014532:1713987:172278317227831723733951Halomonas elongata DSM 2581, complete genometranscriptional regulator, DeoR family4e-26119
NC_003047:3202125:320716032071603208107948Sinorhizobium meliloti 1021, complete genomePUTATIVE TRANSCRIPTIONAL REGULATOR PROTEIN5e-26118
NC_009952:526456:537246537246538217972Dinoroseobacter shibae DFL 12, complete genometranscriptional regulator5e-25115
NC_015137:2616222:264137426413742642321948Burkholderia sp. CCGE1001 chromosome 2, complete sequenceDeoR family transcriptional regulator1e-23110
NC_006085:925604:955443955443956387945Propionibacterium acnes KPA171202, complete genometranscriptional regulator, SorC family7e-22104
NC_010468:1816359:181988518198851820862978Escherichia coli ATCC 8739, complete genometranscriptional regulator, DeoR family2e-20100
NC_011083:3171171:318540631854063186371966Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,putative transcriptional regulator, DeoR family7e-2098.2
NC_014618:3700640:370858437085843709546963Enterobacter cloacae SCF1 chromosome, complete genomeDeoR family transcriptional regulator1e-1997.8
NC_017243:554500:557666557666558598933Brachyspira intermedia PWS/A chromosome, complete genomeDeoR family transcriptional regulator7e-1994.7
NC_019908:2247956:225140022514002252332933Brachyspira pilosicoli P43/6/78 chromosome, complete genomeDeoR family transcriptional regulator9e-1891.3
NC_014330:952500:965033965033965965933Brachyspira pilosicoli 95/1000 chromosome, complete genomeDeoR family transcriptional regulator3e-1789.4
NC_015425:604842:6064226064226074831062Clostridium botulinum BKT015925 chromosome, complete genometranscriptional regulator9e-1787.8
NC_009674:3732000:3743224374322437442521029Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeDeoR family transcriptional regulator1e-1687.8
NC_005945:4854951:4865716486571648667441029Bacillus anthracis str. Sterne, complete genomegapA transcriptional regulator CggR2e-1687
NC_007530:4853740:4864505486450548655331029Bacillus anthracis str. 'Ames Ancestor', complete genomegapa transcriptional regulator cggr2e-1687
NC_003909:4831000:4840793484079348418211029Bacillus cereus ATCC 10987, complete genomegapA transcriptional regulator CggR2e-1687
NC_005957:4850659:4870225487022548712531029Bacillus thuringiensis serovar konkukian str. 97-27, completecentral glycolytic genes regulator2e-1687
NC_014335:4800500:4815383481538348164111029Bacillus cereus biovar anthracis str. CI chromosome, completecentral glycolytic genes regulator2e-1687
NC_012472:4867210:4879350487935048803781029Bacillus cereus 03BB102, complete genomegapA transcriptional regulator CggR2e-1687
NC_003997:4852332:4864379486437948654071029Bacillus anthracis str. Ames, complete genomegapA transcriptional regulator CggR2e-1687
NC_006274:4910465:4922747492274749237751029Bacillus cereus E33L, complete genomecentral glycolytic genes regulator2e-1687
NC_011658:4866184:4878458487845848794861029Bacillus cereus AH187 chromosome, complete genomegapA transcriptional regulator CggR2e-1687
NC_011773:4914601:4926873492687349279011029Bacillus cereus AH820 chromosome, complete genomegapA transcriptional regulator CggR2e-1687
NC_008600:4868000:4877574487757448786171044Bacillus thuringiensis str. Al Hakam, complete genomecentral glycolytic genes regulator1e-1687
NC_015145:1045264:107726610772661078219954Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genometranscriptional regulator with sigma factor-related N-terminal domain2e-1687
NC_017200:4915780:4927903492790349289311029Bacillus thuringiensis serovar finitimus YBT-020 chromosome,central glycolytic genes regulator2e-1687
NC_016779:4825599:4837725483772548387531029Bacillus cereus F837/76 chromosome, complete genomeCentral glycolytic genes regulator2e-1687
NC_016771:4821000:4830781483078148318091029Bacillus cereus NC7401, complete genomegapA transcriptional regulator CggR2e-1687
NC_012659:4853640:4864405486440548654331029Bacillus anthracis str. A0248, complete genomegapA transcriptional regulator CggR2e-1687
NC_012581:4856620:4866828486682848678561029Bacillus anthracis str. CDC 684 chromosome, complete genomegapA transcriptional regulator CggR2e-1687
NC_011969:4802500:4812089481208948131171029Bacillus cereus Q1 chromosome, complete genomecentral glycolytic genes regulator2e-1687
NC_013315:3532721:3533788353378835348101023Clostridium difficile CD196 chromosome, complete genomecentral glycolytic genes regulator1e-1480.5
NC_017179:3540739:3541806354180635428281023Clostridium difficile BI1, complete genomecentral glycolytic genes regulator1e-1480.5
NC_014328:4249032:4262005426200542630301026Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator2e-1479.7
NC_009697:256354:2590692590692601001032Clostridium botulinum A str. ATCC 19397 chromosome, completecentral glycolytic genes regulator2e-1377
NC_014614:757381:7599187599187609581041Clostridium sticklandii, complete genometranscriptional regulator2e-1377
NC_004722:5027762:5043707504370750447501044Bacillus cereus ATCC 14579, complete genomeCentral glycolytic genes regulator3e-1376.3
NC_017353:2129738:2142147214214721431661020Staphylococcus lugdunensis N920143, complete genomeglycolytic operon regulator3e-1376.3
NC_017208:5096759:5108978510897851100061029Bacillus thuringiensis serovar chinensis CT-43 chromosome, completecentral glycolytic genes regulator4e-1375.9
NC_014171:4933200:4945129494512949461571029Bacillus thuringiensis BMB171 chromosome, complete genomecentral glycolytic genes regulator4e-1375.9
NC_011725:5043198:5055404505540450564321029Bacillus cereus B4264 chromosome, complete genomegapA transcriptional regulator CggR4e-1375.9
NC_011772:4994500:5009169500916950101971029Bacillus cereus G9842, complete genomegapA transcriptional regulator CggR4e-1375.9
NC_010184:4879552:4896488489648848975161029Bacillus weihenstephanensis KBAB4, complete genometranscriptional regulator, DeoR family5e-1375.5
NC_010718:2116889:2129349212934921303771029Natranaerobius thermophilus JW/NM-WN-LF, complete genometranscriptional regulator, DeoR family5e-1375.5
NC_015389:616430:671911671911672867957Coriobacterium glomerans PW2 chromosome, complete genometranscriptional regulator, DeoR family1e-1274.3
NC_015519:2045935:2059066205906620601181053Tepidanaerobacter sp. Re1 chromosome, complete genomeDeoR family transcriptional regulator2e-1273.2
NC_004557:363628:3664713664713674991029Clostridium tetani E88, complete genomeputative central glycolytic genes regulator8e-1271.2
NC_016605:233087:245383245383246333951Pediococcus claussenii ATCC BAA-344 chromosome, complete genomeputative sugar-binding domain protein2e-1170.5
NC_013205:2332174:2335308233530823363811074Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,transcriptional regulator, DeoR family3e-1169.3
NC_007350:1971762:1984033198403319850611029Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,glycolytic operon regulator3e-1169.3
NC_009487:866000:8734438734438744561014Staphylococcus aureus subsp. aureus JH9 chromosome, completeDeoR family transcriptional regulator2e-1067
NC_020291:5641444:5652749565274956537981050Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecentral glycolytic genes regulator2e-1066.6
NC_016941:807155:8150918150918161041014Staphylococcus aureus subsp. aureus MSHR1132, complete genomeglycolytic operon regulator4e-1065.5