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Query: NC_009698:3526359:3530717 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3530717, End: 3531112, Length: 396

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:3629250:363360836336083634003396Clostridium botulinum A str. ATCC 19397 chromosome, completeglucitol operon activator protein1e-63241
NC_012563:3921859:392552239255223925917396Clostridium botulinum A2 str. Kyoto, complete genomeglucitol operon activator protein3e-63239
NC_012658:3744000:374853337485333748928396Clostridium botulinum Ba4 str. 657 chromosome, complete genomeglucitol operon activator protein4e-61233
NC_010520:3753875:375818537581853758580396Clostridium botulinum A3 str. Loch Maree, complete genomeglucitol operon activator protein1e-60231
NC_017297:3752000:375906337590633759458396Clostridium botulinum F str. 230613 chromosome, complete genomeglucitol operon activator protein1e-60231
NC_009699:3753599:376045037604503760845396Clostridium botulinum F str. Langeland chromosome, complete genomeglucitol operon activator protein1e-60231
NC_010516:3724312:372867137286713729066396Clostridium botulinum B1 str. Okra, complete genomeglucitol operon activator protein1e-60231
NC_014377:1400544:140392014039201404285366Thermosediminibacter oceani DSM 16646 chromosome, complete genomeGlucitol operon activator5e-1476.3
NC_015519:686027:688825688825689217393Tepidanaerobacter sp. Re1 chromosome, complete genomeglucitol operon activator1e-1374.7
NC_017316:2710021:271057527105752711060486Enterococcus faecalis OG1RF chromosome, complete genometranscriptional regulator SrlR1e-1272
NC_004668:3184319:318894431889443189429486Enterococcus faecalis V583, complete genometranscriptional regulator SrlR1e-1272
NC_015389:1782825:179144617914461791955510Coriobacterium glomerans PW2 chromosome, complete genomeGlucitol operon activator1e-1271.6
NC_007930:180281:184097184097184594498Lactobacillus salivarius subsp. salivarius UCC118 plasmid pMP118,Sorbitol operon activator7e-1166.2
NC_015637:891842:894712894712895068357Vibrio anguillarum 775 chromosome chromosome II, complete sequenceglucitol operon activator protein7e-0959.3