Pre_GI: BLASTP Hits

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Query: NC_009698:3275839:3275839 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3275839, End: 3276813, Length: 975

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010516:3466000:347106934710693472043975Clostridium botulinum B1 str. Okra, complete genomeputative CoA-substrate-specific enzyme activase0644
NC_021182:4088000:410867741086774109630954Clostridium pasteurianum BC1, complete genomeCoA-substrate-specific enzyme activase, putative2e-129462
NC_015425:2528549:256470925647092565647939Clostridium botulinum BKT015925 chromosome, complete genomeputative CoA-substrate-specific enzyme activase4e-119427
NC_014377:1227850:122938612293861230357972Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCoA-substrate-specific enzyme activase2e-105382
NC_016584:1436710:145659314565931457555963Desulfosporosinus orientis DSM 765 chromosome, complete genomeCoA-substrate-specific enzyme activase1e-103376
NC_010718:128423:128423128423129397975Natranaerobius thermophilus JW/NM-WN-LF, complete genomeCoA-substrate-specific enzyme activase1e-102372
NC_011830:633195:6391766391766402791104Desulfitobacterium hafniense DCB-2, complete genomeCoA-substrate-specific enzyme activase8e-75280
NC_009483:1779601:1791041179104117941513111Geobacter uraniireducens Rf4 chromosome, complete genomeputative CoA-substrate-specific enzyme activase1e-59230
NC_014314:576465:604657604657605466810Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeCoA-substrate-specific enzyme activase1e-55217
NC_015732:2762424:2777720277772027823304611Spirochaeta caldaria DSM 7334 chromosome, complete genomeCoA-substrate-specific enzyme activase3e-48192
NC_015578:1430112:1430112143011214345364425Treponema primitia ZAS-2 chromosome, complete genomeCoA enzyme activase2e-41169
NC_013410:3192836:3192836319283631972874452Fibrobacter succinogenes subsp. succinogenes S85 chromosome,CoA-substrate-specific enzyme activase1e-40167
NC_014926:608894:6294446294446326473204Thermovibrio ammonificans HB-1 chromosome, complete genomeCoA-substrate-specific enzyme activase3e-37155
NC_014484:1690272:1690272169027216947054434Spirochaeta thermophila DSM 6192 chromosome, complete genomehypothetical protein7e-37154
NC_007503:1047577:1054611105461110562631653Carboxydothermus hydrogenoformans Z-2901, complete genomeputative CoA dehydratase subunit/(R)-2-hydroxyglutaryl-CoA dehydratase activator2e-34146
NC_017098:1542284:1577543157754315820184476Spirochaeta africana DSM 8902 chromosome, complete genomeactivator of 2-hydroxyglutaryl-CoA dehydratase2e-34146
NC_021184:569653:5696535696535739394287Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein3e-33142
NC_020291:1535402:1557937155793715621694233Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative CoA-substrate-specific enzyme activase7e-33141
NC_011145:4365730:4365730436573043699984269Anaeromyxobacter sp. K, complete genomeCoA-substrate-specific enzyme activase2e-32140
NC_009697:2265409:2283125228312522848191695Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit/ R-2-hydroxyglutaryl-CoA dehydratase activase3e-32139
NC_010516:2374000:2391090239109023927841695Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit/putative R-2-hydroxyglutaryl-CoA dehydratase activase9e-32137
NC_012563:2466000:246994924699492470722774Clostridium botulinum A2 str. Kyoto, complete genome2-hydroxyglutaryl-CoA dehydratase component A1e-31137
NC_012563:2466000:2483195248319524848861692Clostridium botulinum A2 str. Kyoto, complete genomebenzoyl-CoA reductase, subunit A2e-31136
NC_012658:2393427:2410751241075124124421692Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative CoA-substrate-specific enzyme activase2e-31136
NC_020134:1243122:1240063124006312431493087Clostridium stercorarium subsp. stercorarium DSM 8532, completeCoA-substrate-specific enzyme activase2e-31136
NC_009012:1595498:1613874161387416181754302Clostridium thermocellum ATCC 27405, complete genomeputative CoA-substrate-specific enzyme activase3e-31136
NC_010520:3526883:352971535297153530473759Clostridium botulinum A3 str. Loch Maree, complete genomeputative CoA-substrate-specific enzyme activase6e-31135
NC_012658:2393427:239804723980472398820774Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative CoA-substrate-specific enzyme activase4e-31135
NC_015275:2712991:2712991271299127172114221Clostridium lentocellum DSM 5427 chromosome, complete genomeCoA-substrate-specific enzyme activase7e-31134
NC_011832:1148859:117832011783201179126807Candidatus Methanosphaerula palustris E1-9c, complete genomeCoA-substrate-specific enzyme activase9e-31134
NC_010516:2374000:237800923780092378782774Clostridium botulinum B1 str. Okra, complete genome2-hydroxyglutaryl-CoA dehydratase component A1e-30134
NC_009922:2323083:2344275234427523485614287Alkaliphilus oremlandii OhILAs, complete genomeputative CoA-substrate-specific enzyme activase1e-30133
NC_009698:2265475:227009222700922270865774Clostridium botulinum A str. Hall chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase2e-30133
NC_009697:2265409:227002622700262270799774Clostridium botulinum A str. ATCC 19397 chromosome, complete2-hydroxyglutaryl-CoA dehydratase subunit A2e-30133
NC_010814:3048441:3088379308837930908232445Geobacter lovleyi SZ, complete genome8e-29127
NC_003454:822804:832898832898833695798Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeActivator of (R)-2-hydroxyglutaryl-CoA dehydratase2e-28127
NC_009943:1043210:104577010457701046591822Candidatus Desulfococcus oleovorans Hxd3, complete genomeputative CoA-substrate-specific enzyme activase2e-28126
NC_016627:3205333:3228073322807332323774305Clostridium clariflavum DSM 19732 chromosome, complete genomehypothetical protein4e-28125
NC_012815:1494263:1514476151447615191944719Bifidobacterium animalis subsp. lactis DSM 10140, complete genomehypothetical protein4e-27122
NC_012814:1494331:1514758151475815194764719Bifidobacterium animalis subsp. lactis Bl-04, complete genomehypothetical protein4e-27122
NC_011835:625472:6456876456876503544668Bifidobacterium animalis subsp. lactis AD011 chromosome, completeactivator of 2-hydroxyglutaryl-CoA dehydratase4e-27122
NC_017214:191791:2120042120042167644761Bifidobacterium animalis subsp. lactis BB-12 chromosome, completeActivator of (R)-2-hydroxyglutaryl-CoA dehydratase4e-27122
NC_017215:1499179:1519392151939215241524761Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,Activator of (R)-2-hydroxyglutaryl-CoA dehydratase4e-27122
NC_017216:1494190:1514403151440315190794677Bifidobacterium animalis subsp. lactis BLC1, complete genomeputative CoA-substrate-specific enzyme activase4e-27122
NC_017217:1499832:1520045152004515247634719Bifidobacterium animalis subsp. lactis V9 chromosome, completehypothetical protein4e-27122
NC_013171:342714:3533263533263576004275Anaerococcus prevotii DSM 20548, complete genomeCoA-substrate-specific enzyme activase3e-26119
NC_012563:3729817:373987437398743740668795Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase activator2e-25117
NC_013315:435599:443065443065443874810Clostridium difficile CD196 chromosome, complete genomeactivator of 2-hydroxyisocaproyl-CoA dehydratase1e-25117
NC_017179:446564:452637452637453437801Clostridium difficile BI1, complete genomeactivator of 2-hydroxyisocaproyl-CoA dehydratase1e-25117
NC_009699:3581376:359145035914503592244795Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase activator2e-25116
NC_010516:3545017:355872635587263559520795Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase activator2e-25116
NC_009698:3359766:337091433709143371708795Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase activator2e-25116
NC_009697:3463736:347380634738063474600795Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase activator2e-25116
NC_019908:2401577:2401577240157724026471071Brachyspira pilosicoli P43/6/78 chromosome, complete genomeCoA-substrate-specific enzyme activase2e-25116
NC_015589:2846000:286744428674442868220777Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeCoA-substrate-specific enzyme activase3e-23109
NC_014828:2038692:208228120822812083090810Ethanoligenens harbinense YUAN-3 chromosome, complete genomeCoA-substrate-specific enzyme activase3e-23109
NC_009464:3058665:3079639307963930808951257Uncultured methanogenic archaeon RC-I, complete genomeputative 2-hydroxyglutaryl-CoA dehydratase activator, component C (archerase)5e-23108
NC_015574:1676798:1682748168274816839831236Methanobacterium sp. SWAN-1 chromosome, complete genomemethanogenesis marker protein 152e-22106
NC_014253:1818000:1828187182818718294431257Methanohalobium evestigatum Z-7303 chromosome, complete genomemethanogenesis marker protein 152e-22106
NC_007681:1157402:1173252117325211745051254Methanosphaera stadtmanae DSM 3091, complete genomepredicted activator of 2-hydroxyglutaryl-CoA dehydratase2e-22106
NC_018876:1551155:1551155155115515523961242Methanolobus psychrophilus R15 chromosome, complete genomeBadF/BadG/BcrA/BcrD ATPase4e-22105
NC_010003:1746319:1755877175587717603404464Petrotoga mobilis SJ95, complete genomeCoA-substrate-specific enzyme activase9e-22104
NC_013887:189400:192714192714193445732Methanocaldococcus sp. FS406-22 chromosome, complete genomeCoA-substrate-specific enzyme activase1e-21103
NC_015216:652266:6617006617006629321233Methanobacterium sp. AL-21 chromosome, complete genomemethanogenesis marker protein 155e-21102
NC_010337:147664:177486177486178340855Heliobacterium modesticaldum Ice1, complete genomeactivator of (r)-2-hydroxyglutaryl-coa dehydratase domain protein4e-21102
NC_015562:1189111:121368012136801214414735Methanotorris igneus Kol 5 chromosome, complete genomeCoA-substrate-specific enzyme activase9e-21100
NC_007519:64157:819938199382772780Desulfovibrio alaskensis G20 chromosome, complete genomeCoA enzyme activase2e-20100
NC_018515:4442500:444366244436624444450789Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeCoA-substrate-specific enzyme activase1e-1687
NC_009012:3653111:366096036609603661730771Clostridium thermocellum ATCC 27405, complete genomeputative CoA-substrate-specific enzyme activase3e-1686.3
NC_013887:90929:115352115352116029678Methanocaldococcus sp. FS406-22 chromosome, complete genomeCoA-substrate-specific enzyme activase3e-1686.3
NC_016627:3815690:383284638328463833625780Clostridium clariflavum DSM 19732 chromosome, complete genomeCoA-substrate-specific enzyme activase, putative2e-1583.2
NC_009943:1043210:104658810465881047358771Candidatus Desulfococcus oleovorans Hxd3, complete genomeputative CoA-substrate-specific enzyme activase2e-1583.2