Pre_GI: BLASTP Hits

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Query: NC_009698:2727203:2746978 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2746978, End: 2747577, Length: 600

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:2930244:294821429482142948813600Clostridium botulinum Ba4 str. 657 chromosome, complete genomechemotaxis protein CheC2e-112404
NC_009697:2790277:281005228100522810651600Clostridium botulinum A str. ATCC 19397 chromosome, completechemotaxis protein CheC2e-112404
NC_009495:2876865:289664028966402897239600Clostridium botulinum A str. ATCC 3502 chromosome, complete genomechemotaxis protein CheC2e-112404
NC_010520:2937981:295614229561422956741600Clostridium botulinum A3 str. Loch Maree, complete genomechemotaxis protein CheC2e-112404
NC_012563:3090954:311072931107293111328600Clostridium botulinum A2 str. Kyoto, complete genomechemotaxis protein CheC2e-112404
NC_010516:2900057:291578629157862916385600Clostridium botulinum B1 str. Okra, complete genomechemotaxis protein CheC1e-111401
NC_009699:2901497:292031929203192920918600Clostridium botulinum F str. Langeland chromosome, complete genomechemotaxis protein CheC1e-111401
NC_017297:2905138:292045629204562921055600Clostridium botulinum F str. 230613 chromosome, complete genomechemotaxis protein CheC1e-111401
NC_021182:2921000:294014029401402940742603Clostridium pasteurianum BC1, complete genomechemotaxis protein CheC, inhibitor of MCP methylation8e-84309
NC_004557:1826977:184109818410981841703606Clostridium tetani E88, complete genomechemotaxis protein cheC2e-82304
NC_014328:1046958:105594910559491056548600Clostridium ljungdahlii ATCC 49587 chromosome, complete genomechemotaxis protein CheC6e-82303
NC_008593:1060548:107795310779531078555603Clostridium novyi NT, complete genomechemotaxis protein CheC1e-78291
NC_015425:1207314:120935712093571209944588Clostridium botulinum BKT015925 chromosome, complete genomeCheC, inhibitor of MCP methylation3e-78290
NC_017295:2286911:230849623084962309098603Clostridium acetobutylicum EA 2018 chromosome, complete genomeChemotaxis protein CheC8e-78289
NC_009617:4946000:495905049590504959652603Clostridium beijerinckii NCIMB 8052 chromosome, complete genomechemotaxis protein CheC1e-68259
NC_020291:4944835:499691149969114997513603Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomechEC CheY-P phosphatase CheC2e-66251
NC_008346:983816:995462995462996088627Syntrophomonas wolfei subsp. wolfei str. Goettingen, completeCheC, inhibitor of MCP methylation4e-45180
NC_010001:3266561:327678432767843277401618Clostridium phytofermentans ISDg, complete genomeCheC, inhibitor of MCP methylation2e-37155
NC_012778:841934:851853851853852503651Eubacterium eligens ATCC 27750, complete genomechemotaxis protein CheC6e-36150
NC_021184:2238500:224703122470312247651621Desulfotomaculum gibsoniae DSM 7213, complete genomechemotaxis protein CheC, inhibitor of MCP methylation4e-35147
NC_014377:1089894:109813610981361098774639Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCheC, inhibitor of MCP methylation8e-32136
NC_015391:2099472:210235621023562102931576Carnobacterium sp. 17-4 chromosome, complete genomesignal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)7e-28123
NC_017095:166896:190397190397191011615Fervidobacterium pennivorans DSM 9078 chromosome, complete genomechemotaxis protein CheC, inhibitor of MCP methylation1e-27122
NC_011653:1728000:174618717461871746804618Thermosipho africanus TCF52B, complete genomeCheY-P phosphatase CheC1e-27122
NC_016012:561687:563854563854564459606Candidatus Arthromitus sp. SFB-rat-Yit, complete genomechemotaxis protein CheC2e-27121
NC_015707:705628:705628705628706236609Thermotoga thermarum DSM 5069 chromosome, complete genomeMCP methylation inhibitor CheC1e-24112
NC_015474:1035834:104550610455061046135630Pyrococcus sp. NA2 chromosome, complete genomehypothetical protein2e-22105
NC_015680:1315040:135402113540211354650630Pyrococcus yayanosii CH1 chromosome, complete genomecheC-2 chemotaxis protein cheC6e-22103
NC_000868:1502276:151081415108141511458645Pyrococcus abyssi GE5, complete genomechea histidine kinase related protein4e-21101
NC_000961:435489:443097443097443735639Pyrococcus horikoshii OT3, complete genomehypothetical protein4e-21100
NC_000917:940088:945645945645946262618Archaeoglobus fulgidus DSM 4304, complete genomehypothetical protein6e-21100
NC_011832:1949717:196904219690421969656615Candidatus Methanosphaerula palustris E1-9c, complete genomeCheC, inhibitor of MCP methylation8e-21100
NC_013849:933913:940497940497941105609Ferroglobus placidus DSM 10642 chromosome, complete genomeCheC, inhibitor of MCP methylation4e-2097.8
NC_015680:1315040:135464713546471355258612Pyrococcus yayanosii CH1 chromosome, complete genomechemotaxis protein cheC2e-1789
NC_013741:1144592:116960511696051170201597Archaeoglobus profundus DSM 5631, complete genomeCheC, inhibitor of MCP methylation3e-1788.2
NC_000868:1502276:151017915101791510817639Pyrococcus abyssi GE5, complete genomechea histidine kinase1e-1582.8
NC_000961:435489:443732443732444367636Pyrococcus horikoshii OT3, complete genomehypothetical protein4e-1581.3
NC_007796:1291671:129603712960371296693657Methanospirillum hungatei JF-1, complete genomeCheC, inhibitor of MCP methylation6e-1580.5
NC_020389:1346358:135246813524681353118651Methanosarcina mazei Tuc01, complete genomeChemotaxis protein CheC6e-1580.5
NC_003901:1568000:157746315774631578101639Methanosarcina mazei Go1, complete genomechemotaxis protein8e-1580.1
NC_015474:1035834:104613210461321046758627Pyrococcus sp. NA2 chromosome, complete genomechea histidine kinase6e-1477.4
NC_019892:376000:395178395178395810633Singulisphaera acidiphila DSM 18658 chromosome, complete genomechemotaxis protein CheC, inhibitor of MCP methylation3e-1168.6
NC_013202:2042776:206650120665012067094594Halomicrobium mukohataei DSM 12286, complete genomeCheC, inhibitor of MCP methylation1e-0859.7
NC_002973:730942:7475427475427490561515Listeria monocytogenes str. 4b F2365, complete genomeflagellar motor switch protein6e-0753.9
NC_011660:1889504:1910686191068619122331548Listeria monocytogenes HCC23 chromosome, complete genomeflagellar motor switch protein7e-0753.9
NC_012488:732233:7415017415017430481548Listeria monocytogenes Clip81459, complete genomeflagellar motor switch protein7e-0753.9
NC_003210:721824:7330177330177345641548Listeria monocytogenes EGD-e, complete genomeflagellar motor switch protein1e-0653.5
NC_013766:757987:7705407705407720871548Listeria monocytogenes 08-5578 chromosome, complete genomeflagellar motor switch protein1e-0653.5
NC_013768:721897:7372447372447387911548Listeria monocytogenes 08-5923, complete genomeflagellar motor switch protein1e-0653.5
NC_009633:2725128:2725128272512827263091182Alkaliphilus metalliredigens QYMF chromosome, complete genomeflagellar motor switch protein8e-0753.5
NC_008555:696217:6972126972126987501539Listeria welshimeri serovar 6b str. SLCC5334, complete genomeflagellar motor switch domain protein1e-0653.1
NC_003212:721112:7323047323047338451542Listeria innocua Clip11262, complete genomeflagellar motor switch protein5e-0650.8