Pre_GI: BLASTP Hits

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Query: NC_009698:2727203:2743142 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2743142, End: 2743423, Length: 282

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2790277:280621628062162806497282Clostridium botulinum A str. ATCC 19397 chromosome, completeregulator of flagellin synthesis FlgM3e-45179
NC_009495:2876865:289280428928042893085282Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeregulator of flagellin synthesis FlgM3e-45179
NC_010516:2900057:291185729118572912138282Clostridium botulinum B1 str. Okra, complete genomeregulator of flagellin synthesis FlgM3e-45179
NC_010520:2937981:295221329522132952494282Clostridium botulinum A3 str. Loch Maree, complete genomeregulator of flagellin synthesis FlgM3e-45179
NC_012563:3090954:310689331068933107174282Clostridium botulinum A2 str. Kyoto, complete genomeregulator of flagellin synthesis FlgM3e-45179
NC_017297:2905138:291652929165292916810282Clostridium botulinum F str. 230613 chromosome, complete genomeregulator of flagellin synthesis FlgM6e-44175
NC_009699:2901497:291639129163912916672282Clostridium botulinum F str. Langeland chromosome, complete genomeregulator of flagellin synthesis FlgM6e-44175
NC_012658:2930244:294437829443782944659282Clostridium botulinum Ba4 str. 657 chromosome, complete genomeregulator of flagellin synthesis FlgM2e-43174
NC_021182:2921000:293644429364442936731288Clostridium pasteurianum BC1, complete genomeflagellar biosynthesis anti-sigma factor FlgM7e-1579.3
NC_014328:1046958:106007210600721060344273Clostridium ljungdahlii ATCC 49587 chromosome, complete genomenegative regulator of flagellin synthesis2e-1477.8
NC_010723:801215:802725802725803003279Clostridium botulinum E3 str. Alaska E43, complete genomenegative regulator of flagellin synthesis3e-1270.5
NC_015425:1207314:121321712132171213492276Clostridium botulinum BKT015925 chromosome, complete genomeflagellin synthesis regulator FlgM1e-1168.6
NC_020291:4944835:499289249928924993167276Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeanti-sigma-28 factor, FlgM family1e-1064.7
NC_009617:4946000:495444549544454954720276Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeanti-sigma-28 factor FlgM2e-1064.7
NC_008593:1060548:108177910817791082039261Clostridium novyi NT, complete genomeregulator of flagellin synthesis, FLGM8e-1062.4
NC_017295:2286911:230497623049762305257282Clostridium acetobutylicum EA 2018 chromosome, complete genomeRegulator of flagellin synthesis, FLGM2e-0754.3