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Query: NC_009698:2727203:2742738 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2742738, End: 2743142, Length: 405

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2790277:280581228058122806216405Clostridium botulinum A str. ATCC 19397 chromosome, completeflgN family protein2e-61234
NC_009495:2876865:289240028924002892804405Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeflgN family protein2e-61234
NC_010516:2900057:291145329114532911857405Clostridium botulinum B1 str. Okra, complete genomeflgN family protein2e-61234
NC_012563:3090954:310648931064893106893405Clostridium botulinum A2 str. Kyoto, complete genomeflgN family protein2e-61234
NC_010520:2937981:295180929518092952213405Clostridium botulinum A3 str. Loch Maree, complete genomeflgN family protein6e-61232
NC_009699:2901497:291598729159872916391405Clostridium botulinum F str. Langeland chromosome, complete genomeflgN family protein2e-60230
NC_017297:2905138:291612529161252916529405Clostridium botulinum F str. 230613 chromosome, complete genomeflgN family protein2e-60230
NC_012658:2930244:294397429439742944378405Clostridium botulinum Ba4 str. 657 chromosome, complete genomeflgN family protein6e-60229
NC_014328:1046958:106037210603721060779408Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein3e-1994
NC_009617:4946000:495403249540324954442411Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeFlgN family protein1e-1891.7
NC_017295:2286911:230456623045662304973408Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein2e-1891.3
NC_004557:1826977:183715418371541837561408Clostridium tetani E88, complete genomehypothetical protein3e-1890.5
NC_015425:1207314:121352412135241213961438Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein2e-1787.8
NC_008593:1060548:108214410821441082542399Clostridium novyi NT, complete genomehypothetical protein1e-1685.1
NC_010723:801215:803007803007803417411Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-1685.1
NC_021182:2921000:293603229360322936442411Clostridium pasteurianum BC1, complete genomeFlgN protein2e-1684.7
NC_020291:4944835:499247949924794992889411Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeFlgN family protein6e-1476.3
NC_017179:281069:301784301784302200417Clostridium difficile BI1, complete genomeflagellar biosynthesis protein7e-1165.9
NC_015913:624859:627795627795628205411Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomeFlgN family protein2e-1064.7
NC_016012:561687:567406567406567816411Candidatus Arthromitus sp. SFB-rat-Yit, complete genomeflgN family protein4e-0960.1