Pre_GI: BLASTP Hits

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Query: NC_009698:2727203:2728984 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2728984, End: 2730687, Length: 1704

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2790277:2792058279205827937611704Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein0984
NC_012563:3090954:3092735309273530944381704Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein0984
NC_009495:2876865:2878646287864628803611716Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein0983
NC_012658:2930244:2930244293024429319471704Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein0945
NC_010520:2937981:2937981293798129396841704Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein0929
NC_010674:828191:8385018385018403001800Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-74280
NC_010723:801215:8156808156808174791800Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein4e-74279
NC_009699:2901497:2905000290500029067991800Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-73277
NC_017297:2905138:2905138290513829069371800Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-73277
NC_004557:1826977:1826977182697718287791803Clostridium tetani E88, complete genomehypothetical protein3e-73276
NC_017295:2286911:2294425229442522962031779Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein5e-71269
NC_017295:2286911:2288232228823222898661635Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein1e-64248
NC_015425:1207314:1222328122232812240701743Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein2e-60234
NC_020291:4944835:4982043498204349837851743Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein1e-47191
NC_011899:1807365:1821992182199218238481857Halothermothrix orenii H 168, complete genomehypothetical protein1e-32142
NC_007644:779376:7987177987178006061890Moorella thermoacetica ATCC 39073, complete genomeProtein of unknown function DUF1154e-32139
NC_009012:2661795:2660402266040226618141413Clostridium thermocellum ATCC 27405, complete genomeprotein of unknown function DUF1155e-30132
NC_010674:828191:8407468407468419541209Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-28127
NC_010723:801215:8179268179268191371212Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein2e-28127
NC_015589:1240197:1248213124821312500481836Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein4e-27123
NC_018645:4104302:4104302410430241071812880Desulfobacula toluolica Tol2, complete genomehypothetical protein1e-26121
NC_012781:3087467:3088654308865430905011848Eubacterium rectale ATCC 33656, complete genomehypothetical protein5e-26119
NC_009012:2661795:2662160266216026641061947Clostridium thermocellum ATCC 27405, complete genomeprotein of unknown function DUF1152e-25117
NC_019978:2260395:2268198226819822700991902Halobacteroides halobius DSM 5150, complete genomehypothetical protein4e-24113
NC_012108:4118888:4139378413937841422422865Desulfobacterium autotrophicum HRM2, complete genomehypothetical protein1e-23111
NC_015660:391627:3963213963213981051785Geobacillus thermoglucosidasius C56-YS93 chromosome, completehypothetical protein3e-23110
NC_015660:391627:3984323984323997991368Geobacillus thermoglucosidasius C56-YS93 chromosome, completehypothetical protein9e-23108
NC_014915:3259440:3275250327525032775262277Geobacillus sp. Y412MC52 chromosome, complete genomeprotein of unknown function DUF1151e-21105
NC_020210:3169258:3186543318654331888102268Geobacillus sp. GHH01, complete genomeDUF115 family protein2e-21104
NC_017295:2286911:2292771229277122939881218Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein7e-21102
NC_014650:376070:3812093812093829931785Geobacillus sp. Y4.1MC1 chromosome, complete genomehypothetical protein1e-1998.6
NC_009348:381752:3826703826703850092340Aeromonas salmonicida subsp. salmonicida A449, complete genomehypothetical protein1e-1998.2
NC_014650:376070:3833213833213846881368Geobacillus sp. Y4.1MC1 chromosome, complete genomehypothetical protein6e-1996.3
NC_013522:698114:7049457049457076202676Thermanaerovibrio acidaminovorans DSM 6589, complete genomeprotein of unknown function DUF1157e-1995.9
NC_008570:4594436:4630827463082746321221296Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genomehypothetical protein9e-1995.5
NC_019897:128610:1838111838111860752265Thermobacillus composti KWC4 chromosome, complete genomehypothetical protein5e-1893.2
NC_009922:2721343:2721343272134327231601818Alkaliphilus oremlandii OhILAs, complete genomeprotein of unknown function DUF1156e-1789.4
NC_006510:3133965:3151046315104631529441899Geobacillus kaustophilus HTA426, complete genomehypothetical protein8e-1789
NC_009997:3661083:3687171368717136896512481Shewanella baltica OS195, complete genomeTPR repeat-containing protein4e-1687
NC_008700:2788363:2802822280282228053022481Shewanella amazonensis SB2B, complete genomeconserved hypothetical protein1e-1481.6
NC_009997:3661083:3678530367853036798371308Shewanella baltica OS195, complete genomeprotein of unknown function DUF1151e-1275.5
NC_010337:748467:7637917637917655961806Heliobacterium modesticaldum Ice1, complete genomehypothetical protein2e-1274.7
NC_007954:1494291:1504115150411515065892475Shewanella denitrificans OS217, complete genomeprotein of unknown function DUF1153e-1273.9
NC_016641:945284:9463289463289481451818Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein2e-1170.9
NC_012491:5628000:5648343564834356502111869Brevibacillus brevis NBRC 100599, complete genomehypothetical protein6e-1169.7
NC_009052:3467000:3483441348344134859092469Shewanella baltica OS155, complete genomeprotein of unknown function DUF1152e-1068.2
NC_009092:1504363:1546606154660615479011296Shewanella loihica PV-4, complete genomehypothetical protein2e-1067.8
NC_010424:1857062:1870944187094418728241881Candidatus Desulforudis audaxviator MP104C, complete genomeprotein of unknown function DUF1154e-1066.6
NC_009438:3019552:3034766303476630360551290Shewanella putrefaciens CN-32 chromosome, complete genomehypothetical protein5e-1066.6
NC_011663:1627220:1634705163470516371672463Shewanella baltica OS223 chromosome, complete genomehypothetical protein7e-1065.9
NC_017098:875378:9001059001059019041800Spirochaeta africana DSM 8902 chromosome, complete genomehypothetical protein1e-0965.5
NC_007517:480303:4907964907964933152520Geobacter metallireducens GS-15, complete genomeTPR repeat protein1e-0965.1
NC_008577:1489643:1514043151404315165142472Shewanella sp. ANA-3 chromosome 1, complete sequencehypothetical protein2e-0964.7
NC_009092:1504363:1528142152814215306222481Shewanella loihica PV-4, complete genomeTetratricopeptide TPR_2 repeat protein6e-0756.6
NC_014844:92148:9339993399951801782Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomehypothetical protein6e-0756.2
NC_016112:806256:8285838285838310782496Methylomicrobium alcaliphilum chromosome, complete genomehypothetical protein4e-0653.5