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Query: NC_009698:2450606:2471150 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2471150, End: 2472379, Length: 1230

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2478261:2498805249880525000341230Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein0738
NC_009495:2606238:2626688262668826279171230Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein0738
NC_012563:2761570:2801073280107328023021230Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein0734
NC_017297:2635892:2675202267520226764311230Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein0729
NC_009699:2654672:2675053267505326762821230Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein0729
NC_012658:2641446:2682121268212126833501230Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein0727
NC_010516:2594159:2614734261473426159631230Clostridium botulinum B1 str. Okra, complete genomehypothetical protein0726
NC_010520:2668702:2689232268923226904611230Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein0720
NC_014964:1309845:1326859132685913280641206Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehypothetical protein2e-68259
NC_018664:1729794:1730954173095417321261173Clostridium acidurici 9a chromosome, complete genomeprotein of unknown function DUF7958e-67254
NC_017179:1239991:1241645124164512429251281Clostridium difficile BI1, complete genomehypothetical protein4e-65249
NC_013315:1230214:1231868123186812331481281Clostridium difficile CD196 chromosome, complete genomehypothetical protein4e-65249
NC_013316:1225797:1229484122948412307641281Clostridium difficile R20291, complete genomehypothetical protein4e-65249
NC_014624:2668157:2684487268448726857281242Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein3e-55216
NC_019978:1410041:1428222142822214295111290Halobacteroides halobius DSM 5150, complete genomeputative nucleotidyltransferase9e-52204
NC_000853:1480478:1509521150952115107771257Thermotoga maritima MSB8, complete genomehypothetical protein9e-51201
NC_015437:1038476:1050469105046910517281260Selenomonas sputigena ATCC 35185 chromosome, complete genomeprotein of unknown function DUF7954e-48192
NC_014622:2114244:2122715212271521239501236Paenibacillus polymyxa SC2 chromosome, complete genomehypothetical protein5e-47188
NC_014483:1954856:1963308196330819645431236Paenibacillus polymyxa E681 chromosome, complete genomePredicted nucleotidyltransferase5e-46185
NC_015873:2260048:2262073226207322632841212Megasphaera elsdenii DSM 20460, complete genomeUPF0348 protein HMPREF0889_15402e-38160
NC_004461:813748:8170458170458181781134Staphylococcus epidermidis ATCC 12228, complete genomehypothetical protein3e-36152
NC_002976:707827:7111247111247122571134Staphylococcus epidermidis RP62A, complete genomehypothetical protein2e-35150
NC_006274:3805134:3825997382599738271781182Bacillus cereus E33L, complete genomehypothetical protein2e-34147
NC_011969:3657360:3678141367814136793221182Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-33144
NC_005957:3746891:3767726376772637689071182Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein3e-33142
NC_014335:3675456:3696323369632336975041182Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein5e-33142