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Query: NC_009698:2450606:2466160 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2466160, End: 2466639, Length: 480

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2478261:249381524938152494294480Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein2e-54211
NC_009495:2606238:262169826216982622177480Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-54211
NC_010520:2668702:268424026842402684719480Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein2e-53207
NC_010516:2594159:260974326097432610222480Clostridium botulinum B1 str. Okra, complete genomehypothetical protein8e-53205
NC_009699:2654672:267006226700622670541480Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein8e-53205
NC_017297:2635892:267021026702102670689480Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein8e-53205
NC_012563:2761570:279606827960682796547480Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-52204
NC_012658:2641446:267712526771252677604480Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-51201
NC_015732:2057895:206444820644482064930483Spirochaeta caldaria DSM 7334 chromosome, complete genomehypothetical protein6e-1786.7
NC_010556:316996:319808319808320290483Exiguobacterium sibiricum 255-15, complete genomehypothetical protein9e-1372.8
NC_016048:797762:840797840797841279483Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein4e-0753.9