Pre_GI: BLASTP Hits

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Query: NC_009698:2450606:2458936 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2458936, End: 2461047, Length: 2112

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2478261:2486591248659124887022112Clostridium botulinum A str. ATCC 19397 chromosome, completeD-proline reductase subunit PrdA01405
NC_010520:2668702:2677019267701926791302112Clostridium botulinum A3 str. Loch Maree, complete genomeputative D-proline reductase, PrdA proprotein01395
NC_012658:2641446:2669909266990926720202112Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein01381
NC_009495:2606238:2614478261447826165862109Clostridium botulinum A str. ATCC 3502 chromosome, complete genomesubunit of proline reductase01367
NC_009699:2654672:2663002266300226651102109Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA01365
NC_017297:2635892:2663152266315226652602109Clostridium botulinum F str. 230613 chromosome, complete genomeputative D-proline reductase, PrdA proprotein01365
NC_012563:2761570:2788847278884727909552109Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein01365
NC_010516:2594159:2602523260252326046312109Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein01359
NC_010516:2567911:2584352258435225864662115Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein01183
NC_009699:2635745:2644821264482126469352115Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA01182
NC_017297:2635892:2644968264496826470822115Clostridium botulinum F str. 230613 chromosome, complete genomeD-proline reductase subunit PrdA01182
NC_012658:2641446:2654366265436626564802115Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein01181
NC_012563:2761570:2770649277064927727632115Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein01180
NC_014614:2333890:2342523234252323444121890Clostridium sticklandii, complete genomeD-proline reductase proprotein prdA [Contains: D-proline reductase subunit beta (D-proline reductase 45 kDa subunit); D-proline reductase subunit alph0741
NC_017179:3621306:3630325363032536322051881Clostridium difficile BI1, complete genomeproline reductase subunit proprotein0687
NC_013315:3613288:3622307362230736241871881Clostridium difficile CD196 chromosome, complete genomeproline reductase subunit proprotein0687
NC_009089:3782000:3793823379382337957031881Clostridium difficile 630, complete genomeproline reductase subunit proprotein0687
NC_012563:2761570:279293727929372793599663Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-70268
NC_009495:2606238:261856726185672619229663Clostridium botulinum A str. ATCC 3502 chromosome, complete genome7e-69262
NC_010516:2594159:260661326066132607275663Clostridium botulinum B1 str. Okra, complete genomehypothetical protein6e-69262
NC_010520:2668702:268110926811092681771663Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein6e-69262
NC_017297:2635892:266724026672402667902663Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-68261
NC_009699:2654672:266709226670922667754663Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-68261
NC_009698:2450606:246302924630292463691663Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein3e-68260
NC_009697:2478261:249068424906842491346663Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-68260
NC_012658:2641446:267399426739942674656663Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein4e-66253
NC_017297:2635892:266095026609502661726777Clostridium botulinum F str. 230613 chromosome, complete genomeglycine/sarcosine/betaine reductase, component B subunits alpha and beta6e-46186
NC_009699:2654672:266080026608002661576777Clostridium botulinum F str. Langeland chromosome, complete genome6e-46186
NC_009495:2606238:261227626122762613052777Clostridium botulinum A str. ATCC 3502 chromosome, complete genomePrdD protein3e-45184
NC_012658:2641446:266770626677062668464759Clostridium botulinum Ba4 str. 657 chromosome, complete genome5e-45183
NC_012563:2761570:278664527866452787421777Clostridium botulinum A2 str. Kyoto, complete genome5e-45183
NC_009697:2478261:248438924843892485165777Clostridium botulinum A str. ATCC 19397 chromosome, completePrdD protein4e-45183
NC_009698:2450606:245673424567342457510777Clostridium botulinum A str. Hall chromosome, complete genomePrdD protein4e-45183
NC_010520:2668702:267481726748172675593777Clostridium botulinum A3 str. Loch Maree, complete genomePrdD protein8e-45182
NC_010516:2594159:260032126003212601097777Clostridium botulinum B1 str. Okra, complete genomePrdD protein2e-44181
NC_009089:3782000:379185737918573792624768Clostridium difficile 630, complete genomehypothetical protein7e-44179
NC_017179:3621306:362835936283593629117759Clostridium difficile BI1, complete genomehypothetical protein7e-44179
NC_013315:3613288:362034136203413621099759Clostridium difficile CD196 chromosome, complete genomehypothetical protein7e-44179
NC_014614:2333890:234068223406822341446765Clostridium sticklandii, complete genomeputative uncharacterized protein (PrdD)4e-41170
NC_010520:2668702:268519626851962685624429Clostridium botulinum A3 str. Loch Maree, complete genomePrdA domain protein8e-36152
NC_010516:2594159:261069926106992611127429Clostridium botulinum B1 str. Okra, complete genomePrdA domain protein2e-35150
NC_009698:2450606:246711524671152467543429Clostridium botulinum A str. Hall chromosome, complete genomePrdA domain-containing protein3e-35150
NC_009697:2478261:249477024947702495198429Clostridium botulinum A str. ATCC 19397 chromosome, completePrdA domain-containing protein3e-35150
NC_009495:2606238:262265326226532623081429Clostridium botulinum A str. ATCC 3502 chromosome, complete genome3e-35150
NC_012563:2761570:279703827970382797466429Clostridium botulinum A2 str. Kyoto, complete genomePrdA domain protein3e-35150
NC_017297:2635892:267116626711662671594429Clostridium botulinum F str. 230613 chromosome, complete genomePrdA domain protein3e-35150
NC_009699:2654672:267101826710182671446429Clostridium botulinum F str. Langeland chromosome, complete genomePrdA domain-containing protein3e-35150
NC_012658:2641446:267808326780832678511429Clostridium botulinum Ba4 str. 657 chromosome, complete genomePrdA domain-containing protein4e-35150
NC_014614:2333890:234019623401962340672477Clostridium sticklandii, complete genomeputative uncharacterized protein (PrdE)1e-33145
NC_010520:2668702:267433326743332674803471Clostridium botulinum A3 str. Loch Maree, complete genomePrdE protein8e-34145
NC_012658:2641446:266722226672222667692471Clostridium botulinum Ba4 str. 657 chromosome, complete genome2e-33144
NC_009699:2654672:266031626603162660786471Clostridium botulinum F str. Langeland chromosome, complete genomePrdE protein6e-33143
NC_010516:2594159:259983725998372600307471Clostridium botulinum B1 str. Okra, complete genomePrdE protein1e-32141
NC_009698:2450606:245625024562502456720471Clostridium botulinum A str. Hall chromosome, complete genomePrdE protein5e-32140
NC_009697:2478261:248390524839052484375471Clostridium botulinum A str. ATCC 19397 chromosome, completePrdE protein5e-32140
NC_009495:2606238:261179226117922612262471Clostridium botulinum A str. ATCC 3502 chromosome, complete genomePrdE protein5e-32140
NC_012563:2761570:278616127861612786631471Clostridium botulinum A2 str. Kyoto, complete genome5e-32140
NC_009089:3782000:379137537913753791842468Clostridium difficile 630, complete genomehypothetical protein1e-30135
NC_013315:3613288:361985936198593620326468Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-30135
NC_017179:3621306:362787736278773628344468Clostridium difficile BI1, complete genomehypothetical protein1e-30135
NC_017297:2635892:266057726605772660936360Clostridium botulinum F str. 230613 chromosome, complete genomePrdA domain protein4e-25117
NC_017179:3621306:362737736273773627850474Clostridium difficile BI1, complete genomehypothetical protein9e-1789.4
NC_013315:3613288:361935936193593619841483Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-1689
NC_009089:3782000:379087537908753791357483Clostridium difficile 630, complete genomehypothetical protein1e-1689
NC_010718:497222:5003525003525016381287Natranaerobius thermophilus JW/NM-WN-LF, complete genomeSarcosine reductase3e-0964.3
NC_014614:1259236:1263647126364712649391293Clostridium sticklandii, complete genomeGlycine reductase component B, subunits alpha and beta (Selenoprotein PB alpha/beta) [Contains: Betaine reductase component B subunit beta; Betaine re4e-0963.9
NC_009495:1368000:1372234137223413735201287Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeglycine reductase complex component B, alpha and beta subunits4e-0757.4
NC_009697:1336889:1340854134085413421401287Clostridium botulinum A str. ATCC 19397 chromosome, completeglycine reductase complex component B, alpha and beta subunits4e-0757.4
NC_009698:1337383:1341348134134813426341287Clostridium botulinum A str. Hall chromosome, complete genomeglycine reductase complex component B, alpha and beta subunits4e-0757.4
NC_010516:1382000:1387930138793013892161287Clostridium botulinum B1 str. Okra, complete genomeglycine reductase complex component B, alpha and beta subunits5e-0757
NC_017297:1402349:1406030140603014073161287Clostridium botulinum F str. 230613 chromosome, complete genomeglycine reductase complex component B subunits alpha and beta6e-0756.6
NC_009699:1400000:1405738140573814070241287Clostridium botulinum F str. Langeland chromosome, complete genomeglycine reductase complex component B, alpha and beta subunits6e-0756.6
NC_010520:1427981:1434458143445814357441287Clostridium botulinum A3 str. Loch Maree, complete genomeglycine reductase complex component B, alpha and beta subunits6e-0756.6
NC_012563:1464000:1470030147003014713161287Clostridium botulinum A2 str. Kyoto, complete genomeglycine reductase, subunits ABC9e-0756.2
NC_019908:1225690:1233812123381212360012190Brachyspira pilosicoli P43/6/78 chromosome, complete genomeglycine/sarcosine/betaine reductase component B subunit alpha and beta GrdE1e-0655.8
NC_018604:789575:7965517965517978371287Brachyspira pilosicoli WesB complete genomeglycine/sarcosine/betaine reductase component B alpha and beta GrdE1e-0655.8
NC_018607:662697:6696706696706709561287Brachyspira pilosicoli B2904 chromosome, complete genomeglycine/sarcosine/betaine reductase component B subunit alpha and beta GrdE1e-0655.8
NC_014330:2026193:2033186203318620344721287Brachyspira pilosicoli 95/1000 chromosome, complete genomeglycine/sarcosine/betaine reductase component B alpha and beta GrdE1e-0655.8