Pre_GI: BLASTP Hits

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Query: NC_009698:2450606:2456250 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2456250, End: 2456720, Length: 471

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:2641446:266722226672222667692471Clostridium botulinum Ba4 str. 657 chromosome, complete genome2e-74277
NC_012563:2761570:278616127861612786631471Clostridium botulinum A2 str. Kyoto, complete genome9e-76281
NC_014614:2333890:2342523234252323444121890Clostridium sticklandii, complete genomeD-proline reductase proprotein prdA [Contains: D-proline reductase subunit beta (D-proline reductase 45 kDa subunit); D-proline reductase subunit alph6e-32136
NC_009699:2635745:2644821264482126469352115Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA9e-32135
NC_009697:2478261:2486591248659124887022112Clostridium botulinum A str. ATCC 19397 chromosome, completeD-proline reductase subunit PrdA5e-31133
NC_017297:2635892:2644968264496826470822115Clostridium botulinum F str. 230613 chromosome, complete genomeD-proline reductase subunit PrdA9e-32135
NC_009698:2450606:2458936245893624610472112Clostridium botulinum A str. Hall chromosome, complete genomeD-proline reductase subunit PrdA5e-31133
NC_009699:2654672:2663002266300226651102109Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA5e-31133
NC_012563:2761570:2788847278884727909552109Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein4e-31133
NC_012658:2641446:2654366265436626564802115Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein1e-31135
NC_012658:2641446:2669909266990926720202112Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein5e-31133
NC_012563:2761570:2770649277064927727632115Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein9e-32135
NC_017179:3621306:362787736278773628344468Clostridium difficile BI1, complete genomehypothetical protein3e-56216
NC_017179:3621306:362737736273773627850474Clostridium difficile BI1, complete genomehypothetical protein1e-32139
NC_013315:3613288:361935936193593619841483Clostridium difficile CD196 chromosome, complete genomehypothetical protein9e-33139
NC_009089:3782000:379137537913753791842468Clostridium difficile 630, complete genomehypothetical protein3e-56216
NC_009089:3782000:379087537908753791357483Clostridium difficile 630, complete genomehypothetical protein8e-33139
NC_013315:3613288:361985936198593620326468Clostridium difficile CD196 chromosome, complete genomehypothetical protein3e-56216
NC_017297:2635892:266057726605772660936360Clostridium botulinum F str. 230613 chromosome, complete genomePrdA domain protein3e-63240
NC_009495:2606238:261179226117922612262471Clostridium botulinum A str. ATCC 3502 chromosome, complete genomePrdE protein9e-76281
NC_009697:2478261:248390524839052484375471Clostridium botulinum A str. ATCC 19397 chromosome, completePrdE protein9e-76281
NC_010516:2594159:259983725998372600307471Clostridium botulinum B1 str. Okra, complete genomePrdE protein1e-74278
NC_009699:2654672:266031626603162660786471Clostridium botulinum F str. Langeland chromosome, complete genomePrdE protein4e-75279
NC_010520:2668702:267433326743332674803471Clostridium botulinum A3 str. Loch Maree, complete genomePrdE protein3e-74276
NC_013315:3613288:3622307362230736241871881Clostridium difficile CD196 chromosome, complete genomeproline reductase subunit proprotein3e-33140
NC_017179:3621306:3630325363032536322051881Clostridium difficile BI1, complete genomeproline reductase subunit proprotein3e-33140
NC_009089:3782000:3793823379382337957031881Clostridium difficile 630, complete genomeproline reductase subunit proprotein3e-33140
NC_010516:2567911:2584352258435225864662115Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein9e-32135
NC_017297:2635892:2663152266315226652602109Clostridium botulinum F str. 230613 chromosome, complete genomeputative D-proline reductase, PrdA proprotein5e-31133
NC_010520:2668702:2677019267701926791302112Clostridium botulinum A3 str. Loch Maree, complete genomeputative D-proline reductase, PrdA proprotein2e-31134
NC_010516:2594159:2602523260252326046312109Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein4e-31133
NC_014614:2333890:234019623401962340672477Clostridium sticklandii, complete genomeputative uncharacterized protein (PrdE)2e-57221
NC_009495:2606238:2614478261447826165862109Clostridium botulinum A str. ATCC 3502 chromosome, complete genomesubunit of proline reductase5e-31133