Pre_GI: BLASTP Hits

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Query: NC_009698:2450606:2453835 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2453835, End: 2454704, Length: 870

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2478261:248149024814902482359870Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-153541
NC_009495:2606238:260946726094672610336870Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-152538
NC_017297:2635892:265804926580492658918870Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-152538
NC_009699:2654672:265790026579002658769870Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-152538
NC_012658:2641446:266481226648122665681870Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein4e-151533
NC_012563:2761570:278372327837232784610888Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein5e-150530
NC_010516:2594159:259735925973592598246888Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-150530
NC_010520:2668702:267190226719022672789888Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein4e-149527
NC_012658:2641446:265208826520882652966879Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein4e-107387
NC_009495:2571732:259384725938472594725879Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-107387
NC_010516:2567911:258207425820742582952879Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-107387
NC_012563:2761570:276837127683712769249879Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-106385
NC_009699:2635745:264254326425432643421879Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-106385
NC_017297:2635892:264269026426902643568879Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-106385
NC_017297:2635892:264942026494202650316897Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-98357
NC_009699:2635745:264927226492722650168897Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-98357
NC_012563:2761570:277510327751032775999897Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-98357
NC_012658:2641446:265871326587132659609897Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-96353
NC_014614:2333890:233825323382532339128876Clostridium sticklandii, complete genomeconserved membrane protein of unknown function (PrdG)7e-96350
NC_009089:3782000:378884737888473789728882Clostridium difficile 630, complete genomehypothetical protein4e-78291
NC_013315:3613288:361733136173313618212882Clostridium difficile CD196 chromosome, complete genomehypothetical protein4e-78291
NC_017179:3621306:362534936253493626230882Clostridium difficile BI1, complete genomehypothetical protein4e-78291
NC_007929:1290568:131107413110741311940867Lactobacillus salivarius subsp. salivarius UCC118, complete genomeHypothetical membrane spanning protein1e-44180
NC_014334:369974:376997376997377866870Lactobacillus casei str. Zhang chromosome, complete genomehypothetical protein4e-42171
NC_010999:349252:353723353723354592870Lactobacillus casei, complete genomeHypothetical integral membrane protein4e-42171