Pre_GI: BLASTP Hits

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Query: NC_009698:2265475:2280598 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2280598, End: 2281443, Length: 846

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014328:4073714:409627040962704097115846Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ATP-binding protein6e-99360
NC_015425:718384:718384718384719232849Clostridium botulinum BKT015925 chromosome, complete genomeCobQ/CobB/MinD/ParA family protein3e-81301
NC_008593:640000:661786661786662643858Clostridium novyi NT, complete genomeMinD superfamily P-loop ATPase containing an inserted ferredoxin domain6e-78290
NC_014507:2319842:234322623432262344095870Methanoplanus petrolearius DSM 11571 chromosome, complete genomecobyrinic acid ac-diamide synthase7e-47187
NC_018870:2316499:237018823701882371063876Thermacetogenium phaeum DSM 12270 chromosome, complete genomecobyrinic acid a,c-diamide synthase1e-45183
NC_007498:1848437:185458318545831855458876Pelobacter carbinolicus DSM 2380, complete genomeMinD superfamily P-loop ATPase2e-42172
NC_016048:1390463:139213413921341393012879Oscillibacter valericigenes Sjm18-20, complete genomeputative iron-sulfur binding protein1e-41170
NC_012883:636560:639856639856640743888Thermococcus sibiricus MM 739, complete genomeATPase, ParA/MinD family, containing ferredoxin domains4e-36151
NC_000961:888000:895143895143896045903Pyrococcus horikoshii OT3, complete genomehypothetical protein1e-33143
NC_007498:1848437:185208518520851852933849Pelobacter carbinolicus DSM 2380, complete genomeMinD superfamily P-loop ATPase1e-21103
NC_015425:718384:717563717563718396834Clostridium botulinum BKT015925 chromosome, complete genomeCobQ/CobB/MinD/ParA family protein1e-21103
NC_018870:2316499:237104123710412371898858Thermacetogenium phaeum DSM 12270 chromosome, complete genomecobyrinic acid a,c-diamide synthase3e-2099
NC_009698:2265475:228143422814342282264831Clostridium botulinum A str. Hall chromosome, complete genomeiron-sulfur binding protein6e-2098.2
NC_008593:640000:660941660941661798858Clostridium novyi NT, complete genomeferredoxin4e-1995.5
NC_014328:4073714:409710640971064097936831Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ATP-binding protein7e-1787.8
NC_016048:1390463:139298413929841393865882Oscillibacter valericigenes Sjm18-20, complete genomeputative iron-sulfur binding protein2e-1686.7
NC_014507:2319842:234409223440922344943852Methanoplanus petrolearius DSM 11571 chromosome, complete genomecobyrinic acid ac-diamide synthase4e-1685.5
NC_012883:636560:640749640749641660912Thermococcus sibiricus MM 739, complete genomeATPase, ParA/MinD family, containing ferredoxin domains7e-1684.7
NC_000961:888000:894286894286895146861Pyrococcus horikoshii OT3, complete genomehypothetical protein4e-1375.5
NC_012563:3416509:342687134268713427668798Clostridium botulinum A2 str. Kyoto, complete genomeseptum site-determining protein MinD5e-0755.1
NC_010516:3234791:324838832483883249185798Clostridium botulinum B1 str. Okra, complete genomeseptum site-determining protein MinD5e-0755.1
NC_009698:3046833:306041930604193061216798Clostridium botulinum A str. Hall chromosome, complete genomeseptum site-determining protein MinD5e-0755.1
NC_009699:3217315:323091232309123231709798Clostridium botulinum F str. Langeland chromosome, complete genomeseptum site-determining protein MinD5e-0755.1
NC_000909:446364:455134455134455886753Methanocaldococcus jannaschii DSM 2661, complete genomepolyferredoxin (mvhB)3e-0652.8
NC_013887:245236:275858275858276640783Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein3e-0652.4
NC_015562:1189111:1192575119257511936451071Methanotorris igneus Kol 5 chromosome, complete genomehypothetical protein5e-0652
NC_005791:961500:963269963269964051783Methanococcus maripaludis S2, complete genomeCO dehydrogenase maturation factor8e-0651.2