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Query: NC_009698:2265475:2280182 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2280182, End: 2280502, Length: 321

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014328:4073714:409585340958534096209357Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative dinitrogenase iron-molybdenum cofactor biosynthesis protein2e-44177
NC_015425:718384:719355719355719711357Clostridium botulinum BKT015925 chromosome, complete genomedinitrogenase iron-molybdenum cofactor family protein7e-32135
NC_018870:2316499:236814623681462368502357Thermacetogenium phaeum DSM 12270 chromosome, complete genomeputative rubredoxin2e-24111
NC_015499:1640500:1658857165885716600501194Thermodesulfobium narugense DSM 14796 chromosome, complete genomeATPase-like, ParA/MinD3e-1684
NC_013741:687546:705157705157705573417Archaeoglobus profundus DSM 5631, complete genomeDinitrogenase iron-molybdenum cofactor biosynthesis protein1e-1168.2
NC_002937:255790:273553273553273930378Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completehypothetical protein3e-1167.4
NC_012883:1522920:152555515255551525956402Thermococcus sibiricus MM 739, complete genomeIron-molybdenum cofactor-binding protein7e-1165.9
NC_020409:584000:584009584009584365357Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completehypothetical protein4e-1063.5
NC_012780:430653:433209433209434123915Eubacterium eligens ATCC 27750 plasmid unnamed, complete sequencepeptidylprolyl isomerase1e-0962.4
NC_009615:4693164:473031647303164731191876Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein3e-0960.8
NC_016803:593484:597494597494597880387Desulfovibrio desulfuricans ND132 chromosome, complete genomedinitrogenase iron-molybdenum cofactor biosynthesis protein5e-0960.1
NC_017078:179848:201073201073201831759Selenomonas ruminantium subsp. lactilytica TAM6421 plasmid pSRC1,hypothetical protein7e-0959.3
NC_019942:596000:603371603371603739369Aciduliprofundum sp. MAR08-339, complete genomehypothetical protein1e-0755.1
NC_014314:1230687:124977212497721250158387Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completedinitrogenase iron-molybdenum cofactor biosynthesis protein5e-0753.1