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Query: NC_009698:2265475:2277291 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 2277291, End: 2278523, Length: 1233

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2265409:2277225227722522784571233Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit alpha0798
NC_010516:2374000:2385338238533823865701233Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase, alpha subunit0796
NC_012658:2393427:2404854240485424060861233Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha0795
NC_012563:2466000:2477449247744924786811233Clostridium botulinum A2 str. Kyoto, complete genome(R)-2-hydroxyglutaryl-CoA dehydratase, alpha subunit family0794
NC_013315:435599:4438834438834451151233Clostridium difficile CD196 chromosome, complete genomesubunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase0662
NC_017179:446564:4534524534524546781227Clostridium difficile BI1, complete genomeoxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase subunit0661
NC_009699:3581376:3590222359022235914451224Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase subunit B4e-110398
NC_010516:3545017:3557498355749835587211224Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase, B subunit4e-110398
NC_009697:3463736:3472578347257834738011224Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase subunit B4e-110398
NC_009698:3359766:3369686336968633709091224Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase subunit B4e-110398
NC_012563:3729817:3738646373864637398691224Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase, B subunit6e-110397
NC_003454:822804:8337588337588350861329Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete(R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit1e-86320