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Query: NC_009698:1:14442 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 14442, End: 14894, Length: 453

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:1:144421444214894453Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-57219
NC_009495:1:144271442714879453Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-57219
NC_012563:1:146241462415076453Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein5e-57219
NC_017297:1:144181441814870453Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein6e-57219
NC_010516:1:144711447114923453Clostridium botulinum B1 str. Okra, complete genomehypothetical protein6e-57219
NC_012658:1:145621456215014453Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-55214
NC_009699:1:143821438214804423Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-51201
NC_010520:1:144511445114873423Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein2e-50197
NC_008593:2527064:253269025326902533199510Clostridium novyi NT, complete genomehypothetical protein2e-1685.1
NC_015425:2752482:275809827580982758562465Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein1e-1375.1
NC_014328:1:145991459915102504Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein4e-1270.5
NC_004557:32094:376413764138144504Clostridium tetani E88, complete genomehypothetical protein1e-1065.5
NC_014393:1:151741517415683510Clostridium cellulovorans 743B chromosome, complete genomemetal-dependent phosphohydrolase HD sub domain3e-1063.9
NC_011837:1:148251482515238414Clostridium kluyveri NBRC 12016, complete genomehypothetical protein9e-1062.4
NC_009706:1:148251482515238414Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein9e-1062.4
NC_008261:1:154221542215925504Clostridium perfringens ATCC 13124, complete genomehypothetical protein2e-0961.2
NC_015687:1:147351473515211477Clostridium acetobutylicum DSM 1731 chromosome, complete genomeHD superfamily hydrolase1e-0755.1
NC_003030:1:147351473515211477Clostridium acetobutylicum ATCC 824, complete genomePredicted HD superfamily hydrolase1e-0755.1