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Query: NC_009698:120119:132504 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 132504, End: 133310, Length: 807

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:120117:132502132502133308807Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein2e-152538
NC_009495:128000:139699139699140505807Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-152538
NC_010516:127000:139492139492140298807Clostridium botulinum B1 str. Okra, complete genomeconserved hypothetical protein TIGR002683e-152537
NC_017297:122383:134773134773135579807Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein3e-151534
NC_009699:122000:134508134508135314807Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-151534
NC_012563:122000:133635133635134441807Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein TIGR002685e-150530
NC_010520:121077:133486133486134292807Clostridium botulinum A3 str. Loch Maree, complete genomeconserved hypothetical protein TIGR002681e-147522
NC_012658:125500:137144137144137950807Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-143508
NC_019978:315346:321048321048321878831Halobacteroides halobius DSM 5150, complete genomeTIGR00268 family protein1e-68259
NC_016627:3158353:317466131746613175467807Clostridium clariflavum DSM 19732 chromosome, complete genomehypothetical protein2e-66252
NC_007503:1111457:114127611412761142103828Carboxydothermus hydrogenoformans Z-2901, complete genomeconserved hypothetical protein TIGR002685e-66251
NC_014206:1618988:163005116300511630875825Geobacillus sp. C56-T3 chromosome, complete genomeasparagine synthase8e-63240
NC_006510:1995916:200799820079982008822825Geobacillus kaustophilus HTA426, complete genomehypothetical protein8e-63240
NC_015565:2027279:205581420558142056635822Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein2e-58225
NC_021184:592501:594161594161594973813Desulfotomaculum gibsoniae DSM 7213, complete genomeTIGR00268 family protein2e-56219
NC_016023:1874827:188688418868841887693810Bacillus coagulans 36D1 chromosome, complete genomehypothetical protein1e-55216
NC_014378:261064:280949280949281767819Acetohalobium arabaticum DSM 5501 chromosome, complete genomePP-loop domain protein1e-54213
NC_012108:2037429:205316720531672053997831Desulfobacterium autotrophicum HRM2, complete genomeATP-utilizing protein of the PP-loop superfamily2e-54212
NC_009486:1737703:179026617902661791072807Thermotoga petrophila RKU-1 chromosome, complete genomeExsB family protein1e-53209
NC_013741:27353:408874088741666780Archaeoglobus profundus DSM 5631, complete genomeExsB family protein3e-52205
NC_008816:1476209:151058015105801511404825Prochlorococcus marinus str. AS9601, complete genomeATP-utilizing enzymes of the PP-loop superfamily5e-49194
NC_008817:1538507:154405215440521544810759Prochlorococcus marinus str. MIT 9515, complete genomeATP-utilizing enzymes of the PP-loop superfamily9e-49193
NC_011832:1148859:118098411809841181799816Candidatus Methanosphaerula palustris E1-9c, complete genomePP-loop domain-containing protein2e-46186
NC_007955:1498777:151106115110611511864804Methanococcoides burtonii DSM 6242, complete genomehypothetical protein3e-46185
NC_015320:1159613:116026811602681161041774Archaeoglobus veneficus SNP6 chromosome, complete genomehypothetical protein3e-39162
NC_013173:8923:312643126432085822Desulfomicrobium baculatum DSM 4028, complete genomehypothetical protein5e-24111
NC_015636:288797:287988287988288803816Methanothermococcus okinawensis IH1 chromosome, complete genomehypothetical protein7e-1994.4
NC_015954:463500:4768114768114780341224Halophilic archaeon DL31 chromosome, complete genomeArgininosuccinate synthase3e-0652.4
NC_000853:1071078:109261310926131093524912Thermotoga maritima MSB8, complete genomehypothetical protein1e-0550.8