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Query: NC_009698:120119:131210 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 131210, End: 132499, Length: 1290

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:120117:1312081312081324971290Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein0750
NC_009495:128000:1384051384051396941290Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein0750
NC_012563:122000:1323411323411336301290Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein0748
NC_010516:127000:1381861381861394871302Clostridium botulinum B1 str. Okra, complete genomehypothetical protein0726
NC_009699:122000:1332081332081345031296Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein0722
NC_010520:121077:1321681321681334811314Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein0703
NC_012658:125500:1358861358861371391254Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein0702
NC_014328:180482:1986131986131998901278Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein3e-119428
NC_016791:2983349:3011545301154530128551311Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein2e-90333
NC_011297:1357947:1369548136954813707081161Dictyoglomus thermophilum H-6-12, complete genomehypothetical protein3e-87322
NC_009486:1737703:1791817179181717930101194Thermotoga petrophila RKU-1 chromosome, complete genomehypothetical protein3e-87322
NC_014206:1618988:1631678163167816329131236Geobacillus sp. C56-T3 chromosome, complete genomehypothetical protein9e-85314
NC_011661:1542335:1553921155392115550901170Dictyoglomus turgidum DSM 6724, complete genomeprotein of unknown function DUF1112e-83310
NC_007503:1111457:1142854114285411440591206Carboxydothermus hydrogenoformans Z-2901, complete genomehypothetical protein7e-83308
NC_006510:1995916:2005960200596020071951236Geobacillus kaustophilus HTA426, complete genomehypothetical protein1e-81303
NC_015573:649800:6665436665436677361194Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehypothetical protein1e-80300
NC_011768:3385719:3388750338875033899221173Desulfatibacillum alkenivorans AK-01, complete genomeprotein of unknown function DUF1111e-75284
NC_008009:2430509:2432517243251724339051389Acidobacteria bacterium Ellin345, complete genomeprotein of unknown function DUF1112e-67256
NC_016023:1874827:188254518825451883369825Bacillus coagulans 36D1 chromosome, complete genomehypothetical protein1e-52207
NC_013943:2857751:2876779287677928779391161Denitrovibrio acetiphilus DSM 12809 chromosome, complete genomehypothetical protein6e-52205
NC_014624:1369642:137861213786121379340729Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein3e-48192
NC_014122:665684:6781076781076792251119Methanocaldococcus infernus ME chromosome, complete genomeprotein of unknown function DUF1114e-48192
NC_015565:2027279:205252320525232053311789Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein2e-45183
NC_014002:809816:8269898269898281731185Methanohalophilus mahii DSM 5219 chromosome, complete genomeprotein of unknown function DUF1112e-44180
NC_012029:1654816:1675338167533816768161479Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genomeprotein of unknown function DUF1113e-42172
NC_014507:1127115:113784011378401138601762Methanoplanus petrolearius DSM 11571 chromosome, complete genomehypothetical protein2e-34147
NC_009634:299327:326766326766327512747Methanococcus vannielii SB chromosome, complete genomehypothetical protein6e-28125
NC_016023:1874827:188337418833741883844471Bacillus coagulans 36D1 chromosome, complete genomehypothetical protein7e-28125
NC_017297:122383:133470133470133679210Clostridium botulinum F str. 230613 chromosome, complete genome1e-27124
NC_021184:592501:595397595397595861465Desulfotomaculum gibsoniae DSM 7213, complete genome8e-27121
NC_003551:260000:282024282024282554531Methanopyrus kandleri AV19, complete genomehypothetical protein2e-0654.3