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Query: NC_009698:120119:120119 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 120119, End: 120757, Length: 639

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:120117:120117120117120755639Clostridium botulinum A str. ATCC 19397 chromosome, completezinc-dependent hydrolase1e-117421
NC_017297:122383:122383122383123021639Clostridium botulinum F str. 230613 chromosome, complete genomeputative zinc-dependent hydrolase6e-116416
NC_009699:122000:122117122117122755639Clostridium botulinum F str. Langeland chromosome, complete genomezinc-dependent hydrolase6e-116416
NC_010516:127000:127095127095127733639Clostridium botulinum B1 str. Okra, complete genomeputative zinc-dependent hydrolase1e-113408
NC_010520:121077:121077121077121715639Clostridium botulinum A3 str. Loch Maree, complete genomeputative zinc-dependent hydrolase4e-113406
NC_014328:180482:184034184034184666633Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative hydrolase5e-49194
NC_015519:2526047:255363425536342554272639Tepidanaerobacter sp. Re1 chromosome, complete genomeZn-dependent hydrolase1e-44179
NC_010674:192951:212846212846213484639Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein1e-40166
NC_010723:173280:214638214638215276639Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-38159
NC_020291:1045058:104699210469921047636645Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative Zn-dependent hydrolase1e-37156
NC_013849:933913:956159956159956788630Ferroglobus placidus DSM 10642 chromosome, complete genomeZn-dependent hydrolase of the beta-lactamase fold-like protein1e-34146
NC_011297:1296968:131464513146451315283639Dictyoglomus thermophilum H-6-12, complete genomeZn-dependent hydrolase of the metallo-beta-lactamase superfamily3e-34145
NC_008262:2649289:265914326591432659796654Clostridium perfringens SM101, complete genomezinc-dependent hydrolase, putative2e-31135
NC_003366:2788268:279295327929532793606654Clostridium perfringens str. 13, complete genomehypothetical protein3e-31135
NC_008261:3014373:301559230155923016245654Clostridium perfringens ATCC 13124, complete genomeputative zinc-dependent hydrolase6e-31134
NC_015474:538544:570427570427571059633Pyrococcus sp. NA2 chromosome, complete genomehypothetical protein3e-1375.1
NC_007955:1566189:158844915884491589105657Methanococcoides burtonii DSM 6242, complete genomehypothetical protein2e-1272.4
NC_013741:27353:295962959630270675Archaeoglobus profundus DSM 5631, complete genomebeta-lactamase domain protein4e-1271.6
NC_016629:3308329:333518833351883335910723Desulfovibrio africanus str. Walvis Bay chromosome, completehypothetical protein6e-1167.4
NC_016051:1849905:186491418649141865585672Thermococcus sp. AM4 chromosome, complete genomemetal-dependent hydrolase8e-1167
NC_015320:1399589:141515814151581415844687Archaeoglobus veneficus SNP6 chromosome, complete genomehypothetical protein1e-1066.6
NC_015320:1690047:170677517067751707401627Archaeoglobus veneficus SNP6 chromosome, complete genomehypothetical protein3e-0961.6
NC_011296:1542835:154363915436391544259621Thermodesulfovibrio yellowstonii DSM 11347, complete genomemetal dependent hydrolase5e-0961.2
NC_014002:1772060:177206017720601772671612Methanohalophilus mahii DSM 5219 chromosome, complete genomehypothetical protein2e-0859.3
NC_014171:4447856:446989544698954470578684Bacillus thuringiensis BMB171 chromosome, complete genomemetal-dependent hydrolase1e-0757
NC_011725:4562709:458095745809574581640684Bacillus cereus B4264 chromosome, complete genomemetal-dependent hydrolase1e-0756.6
NC_010184:4425676:444678944467894447475687Bacillus weihenstephanensis KBAB4, complete genomebeta-lactamase domain protein1e-0653.1
NC_016779:4361140:438392043839204384603684Bacillus cereus F837/76 chromosome, complete genomeMetal-dependent hydrolase8e-0650.4