Pre_GI: BLASTN Hits

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Query: NC_009697:3110772 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 3110772, End: 3129201, Length: 18430

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_012563:16816391681639170433322695Clostridium botulinum A2 str. Kyoto, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_012563:21014492101449212008818640Clostridium botulinum A2 str. Kyoto, complete genome01445BLASTN svgBLASTP svg
NC_010516:2676746*2676746271365836913Clostridium botulinum B1 str. Okra, complete genome01191BLASTN svgBLASTP svg
NC_010723:22693722269372228916119790Clostridium botulinum E3 str. Alaska E43, complete genome5e-0763.9BLASTN svgBLASTP svg
NC_015875:34270342705351219243Streptococcus pseudopneumoniae IS7493 chromosome, complete genome2e-1695.6BLASTN svgBLASTP svg