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Query: NC_009697:3291500:3304893 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 3304893, End: 3305483, Length: 591

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:3185359:320200032020003202590591Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein4e-103373
NC_009495:3309550:332890433289043329494591Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein4e-103373
NC_012563:3556763:357098335709833571573591Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-103373
NC_010516:3368951:338932733893273389917591Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-102371
NC_012658:3387774:340876734087673409360594Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein7e-98356
NC_014328:3747973:376091637609163761515600Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein1e-37155
NC_003366:2143173:2163776216377621651311356Clostridium perfringens str. 13, complete genomehypothetical protein2e-1065.9
NC_011898:189498:196730196730197167438Clostridium cellulolyticum H10, complete genomeprotein of unknown function DUF7101e-1065.9
NC_014657:291567:309159309159309632474Caldicellulosiruptor owensensis OL chromosome, complete genomehypothetical protein8e-0960.1
NC_020291:1149887:1156724115672411586461923Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecell division protein ZapA1e-0859.3
NC_006322:2886404:289118228911822891439258Bacillus licheniformis ATCC 14580, complete genomeYshA6e-0650.8
NC_006270:2886193:289097128909712891228258Bacillus licheniformis ATCC 14580, complete genomeZapA6e-0650.8