Pre_GI: BLASTP Hits

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Query: NC_009697:2984173:2989683 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 2989683, End: 2991182, Length: 1500

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:2921097:2926607292660729281061500Clostridium botulinum A str. Hall chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0979
NC_009495:3051223:3056733305673330582321500Clostridium botulinum A str. ATCC 3502 chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0979
NC_012563:3288124:3293763329376332952621500Clostridium botulinum A2 str. Kyoto, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0975
NC_010520:3120500:3127137312713731286361500Clostridium botulinum A3 str. Loch Maree, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0950
NC_012658:3126108:3131459313145931329581500Clostridium botulinum Ba4 str. 657 chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0949
NC_021182:2059143:2071561207156120730631503Clostridium pasteurianum BC1, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0744
NC_003366:842000:8537208537208552251506Clostridium perfringens str. 13, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0744
NC_008262:784878:7965287965287980331506Clostridium perfringens SM101, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0741
NC_014328:938393:9466819466819481801500Clostridium ljungdahlii ATCC 49587 chromosome, complete genomebifunctional purine biosynthesis protein PurH0727
NC_003030:1510000:1538696153869615401951500Clostridium acetobutylicum ATCC 824, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0722
NC_008593:1631438:1639266163926616407681503Clostridium novyi NT, complete genomebifunctional purine biosynthesis protein PurH0720
NC_004557:2078000:2087506208750620890051500Clostridium tetani E88, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0710
NC_015425:1867620:1878503187850318800051503Clostridium botulinum BKT015925 chromosome, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0704
NC_009617:1255762:1269218126921812707261509Clostridium beijerinckii NCIMB 8052 chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase0700
NC_014633:265086:2734132734132749091497Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceIMP cyclohydrolase0697
NC_020291:1266885:1277979127797912794871509Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomebifunctional purine biosynthesis protein PurH0696
NC_010674:1124431:1135883113588311373881506Clostridium botulinum B str. Eklund 17B, complete genomebifunctional purine biosynthesis protein PurH0694
NC_010723:1084000:1097782109778210992871506Clostridium botulinum E3 str. Alaska E43, complete genomebifunctional purine biosynthesis protein PurH0691
NC_020134:2295092:2299967229996723015081542Clostridium stercorarium subsp. stercorarium DSM 8532, completebifunctional purine biosynthesis protein PurH1e-149530
NC_015519:1113095:1124851112485111264131563Tepidanaerobacter sp. Re1 chromosome, complete genomebifunctional purine biosynthesis protein purH2e-149529
NC_011567:238249:2618792618792634141536Anoxybacillus flavithermus WK1, complete genomeInosine-monophosphate cyclohydrolase2e-147523
NC_009253:2577316:2585601258560125871421542Desulfotomaculum reducens MI-1 chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase6e-143508
NC_006814:1538175:1544518154451815460591542Lactobacillus acidophilus NCFM, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase2e-142505
NC_014829:443500:4572184572184587531536Bacillus cellulosilyticus DSM 2522 chromosome, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-140500
NC_017179:281069:2895632895632910951533Clostridium difficile BI1, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-140499
NC_004193:783958:7968227968227983541533Oceanobacillus iheyensis HTE831, complete genomeIMP cyclohydrolase2e-140499
NC_018704:433402:4454574454574469861530Amphibacillus xylanus NBRC 15112, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase7e-138491
NC_015391:2488450:2497352249735224988931542Carnobacterium sp. 17-4 chromosome, complete genomebifunctional purine biosynthesis protein PurH3e-137489
NC_014614:356746:3846573846573861711515Clostridium sticklandii, complete genomefused IMP cyclohydrolase ; phosphoribosylaminoimidazolecarboxamide formyltransferase3e-137489
NC_010556:462500:4842644842644857841521Exiguobacterium sibiricum 255-15, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase3e-137488
NC_009633:947695:9608089608089623341527Alkaliphilus metalliredigens QYMF chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase3e-135482
NC_015697:1295412:1295412129541212969501539Lactobacillus reuteri SD2112 chromosome, complete genomebifunctional purine biosynthesis protein PurH4e-134478
NC_013851:949973:9537359537359552941560Allochromatium vinosum DSM 180 chromosome, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-133476
NC_007759:723675:7272697272697288551587Syntrophus aciditrophicus SB, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase5e-133474
NC_009513:169146:1707691707691723071539Lactobacillus reuteri F275, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase1e-132473
NC_004603:3080614:3080614308061430822061593Vibrio parahaemolyticus RIMD 2210633 chromosome I, completebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-132473
NC_011753:3088952:3109471310947131110631593Vibrio splendidus LGP32 chromosome 1, complete genomeBifunctional purine biosynthesis protein purH7e-131468
NC_013656:2317224:2322901232290123244451545Lactococcus lactis subsp. lactis KF147, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase8e-130464
NC_008024:35948:4410244102456491548Streptococcus pyogenes MGAS10750, complete genomePhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase6e-130464
NC_003485:35971:4412544125456721548Streptococcus pyogenes MGAS8232, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase6e-130464
NC_007946:3683371:3698818369881837004071590Escherichia coli UTI89, complete genomebifunctional AICAR formyltransferase/IMP cyclohydrolase1e-129463
NC_015554:4724245:4749136474913647507341599Alteromonas sp. SN2 chromosome, complete genomebifunctionalphosphoribosylaminoimidazolecarboxam ide formyltransferase/IMP cyclohydrolase2e-128459
NC_007614:109000:1379271379271394891563Nitrosospira multiformis ATCC 25196 chromosome 1, completephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-128459
NC_011312:3060371:3079982307998230815741593Aliivibrio salmonicida LFI1238 chromosome chromosome 1, completebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-128459
NC_014498:99015:1064941064941080411548Streptococcus pneumoniae 670-6B chromosome, complete genomebifunctional purine biosynthesis protein PurH3e-128459
NC_010380:124655:1321341321341336811548Streptococcus pneumoniae Hungary19A-6, complete genomebifunctional purine biosynthesis protein PurH4e-128458
NC_004461:746284:7601757601757616531479Staphylococcus epidermidis ATCC 12228, complete genomeIMP cyclohydrolase4e-127455
NC_002976:638799:6526916526916541691479Staphylococcus epidermidis RP62A, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase4e-127455
NC_011999:728353:7483407483407498181479Macrococcus caseolyticus JCSC5402, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase8e-127454
NC_013928:9494:4078440784423461563Streptococcus mutans NN2025, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-126452
NC_012925:29353:3825138251397981548Streptococcus suis P1/7, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-125450
NC_009443:29349:3824738247397941548Streptococcus suis 98HAH33, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-125450
NC_012924:29353:3825138251397981548Streptococcus suis SC84, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-125450
NC_012926:30351:3824938249397961548Streptococcus suis BM407 chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-125450
NC_008023:35663:4381743817453641548Streptococcus pyogenes MGAS2096, complete genomePhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase2e-125449
NC_008021:35661:4384243842453891548Streptococcus pyogenes MGAS9429, complete genomeIMP cyclohydrolase2e-125449
NC_007296:35661:4381543815453621548Streptococcus pyogenes MGAS6180, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-125449
NC_008022:35983:4421044210457571548Streptococcus pyogenes MGAS10270, complete genomePhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase3e-125449
NC_009053:1081651:1100837110083711024261590Actinobacillus pleuropneumoniae L20, complete genomebifunctional purine biosynthesis protein PurH3e-123442
NC_007168:1923723:1929881192988119313591479Staphylococcus haemolyticus JCSC1435, complete genomebifunctional purine biosynthesis protein3e-123442
NC_020164:1784223:1788406178840617898841479Staphylococcus warneri SG1, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase4e-123441
NC_010278:1045884:1066230106623010678191590Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase5e-123441
NC_017501:1352752:1374537137453713761171581Neisseria meningitidis 8013, complete genomebifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) and IMP cycl2e-122440
NC_013355:1332263:1335201133520113368051605Zymomonas mobilis subsp. mobilis NCIB 11163, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase4e-122438
NC_006677:435652:4532954532954548721578Gluconobacter oxydans 621H, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-120434
NC_010519:416658:4407924407924423901599Haemophilus somnus 2336 chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-120433
NC_008309:1827809:1849542184954218511401599Haemophilus somnus 129PT, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase1e-120433
NC_010718:464405:4828154828154843441530Natranaerobius thermophilus JW/NM-WN-LF, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase9e-120431
NC_014935:711765:7290797290797306111533Nitratifractor saLSUginis DSM 16511 chromosome, complete genomeimp cyclohydrolase ;phosphoribosylaminoimidazolecarboxamide formyltransferase7e-119427
NC_009953:4748147:4764574476457447661421569Salinispora arenicola CNS-205 chromosome, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase1e-115416
NC_008942:915871:9381339381339396261494Methanocorpusculum labreanum Z, complete genomehypothetical protein1e-114414
NC_014960:1697818:1719698171969817212031506Anaerolinea thermophila UNI-1, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-113409
NC_015161:36668:5742157421589681548Deinococcus proteolyticus MRP chromosome, complete genomeBifunctional purine biosynthesis protein purH5e-113408
NC_005061:594500:6184626184626201111650Candidatus Blochmannia floridanus, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase, IMP cyclohydrolase and MGS-like domain8e-113407
NC_017256:30192:3364533645352131569Buchnera aphidicola str. Ak (Acyrthosiphon kondoi) chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase6e-112404
NC_011833:31192:3359133591351681578Buchnera aphidicola str. 5A (Acyrthosiphon pisum) chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase4e-109395
NC_017253:31192:3359133591351681578Buchnera aphidicola str. JF99 (Acyrthosiphon pisum) chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase9e-109394
NC_002528:31191:3359033590351671578Buchnera aphidicola str. APS (Acyrthosiphon pisum), completeIMP cyclohydrolase7e-109394
NC_011834:31206:3360533605351821578Buchnera aphidicola str. Tuc7 (Acyrthosiphon pisum) chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase7e-109394
NC_017254:31206:3360533605351821578Buchnera aphidicola str. JF98 (Acyrthosiphon pisum) chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase7e-109394
NC_017255:31211:3361033610351871578Buchnera aphidicola str. LL01 (Acyrthosiphon pisum) chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase7e-109394
NC_016001:224213:2403662403662418921527Flavobacterium branchiophilum, complete genomeBifunctional purine biosynthesis protein PurH4e-108392
NC_017259:25400:3300933009345861578Buchnera aphidicola str. Ua (Uroleucon ambrosiae) chromosome,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase2e-106386
NC_006087:2008000:2023906202390620254861581Leifsonia xyli subsp. xyli str. CTCB07, complete genomebifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase5e-106385
NC_014909:619407:6317396317396334211683Candidatus Blochmannia vafer str. BVAF chromosome, complete genomebifunctional purine biosynthesis protein PurH6e-106384
NC_004061:31500:3399933999355791581Buchnera aphidicola str. Sg (Schizaphis graminum), complete genomebifunctional purine biosynthesis protein2e-105383
NC_014221:78500:8060980609821681560Truepera radiovictrix DSM 17093 chromosome, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase5e-105382
NC_011565:750168:7538467538467553721527Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase5e-105381
NC_016893:218376:2414292414292430151587Wigglesworthia glossinidia endosymbiont of Glossina morsitansphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase3e-103375
NC_004545:15650:3581035810374201611Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase2e-101370
NC_012115:691154:7067567067567082701515Nautilia profundicola AmH, complete genomebifunctional purine biosynthesis protein PurH3e-96352
NC_004344:589375:5893755893755909641590Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,hypothetical protein4e-92338
NC_015732:2710913:2717678271767827194051728Spirochaeta caldaria DSM 7334 chromosome, complete genomeBifunctional purine biosynthesis protein purH2e-82307
NC_012029:904780:9239299239299255361608Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genomephosphoribosylglycinamide formyltransferase5e-57222
NC_014972:2980974:2997239299723929985281290Desulfobulbus propionicus DSM 2032 chromosome, complete genomephosphoribosylaminoimidazolecarboxamide formyltransferase5e-48192
NC_020304:2107979:2127734212773421290231290Desulfocapsa sulfexigens DSM 10523, complete genomeAICAR transformylase/IMP cyclohydrolase PurH4e-46186
NC_014365:2888897:2911183291118329124691287Desulfarculus baarsii DSM 2075 chromosome, complete genomePhosphoribosylaminoimidazolecarboxamideformyltra nsferase1e-45184
NC_011653:748844:748844748844749737894Thermosipho africanus TCF52B, complete genomebifunctional purine biosynthesis protein PurH6e-41169
NC_009718:1207360:1236722123672212380111290Fervidobacterium nodosum Rt17-B1, complete genomeIMP cyclohydrolase1e-39164
NC_017095:2058921:206083520608352061758924Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeAICAR transformylase/IMP cyclohydrolase PurH2e-39164