Pre_GI: BLASTP Hits

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Query: NC_009697:2984173:2987561 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 2987561, End: 2987965, Length: 405

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:2921097:292448529244852924889405Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein2e-72270
NC_009495:3051223:305461130546113055015405Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-72270
NC_012563:3288124:329164232916423292046405Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-69259
NC_012658:3126108:312944031294403129844405Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein5e-68255
NC_010520:3120500:312511131251113125515405Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein1e-67254
NC_012563:2597934:259954025995402599905366Clostridium botulinum A2 str. Kyoto, complete genomephage protein2e-1994.4
NC_009495:1821938:183530418353041835678375Clostridium botulinum A str. ATCC 3502 chromosome, complete genomephage protein1e-1065.1
NC_010674:2856997:286191328619132862206294Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein9e-0752.4