Pre_GI: BLASTP Hits

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Query: NC_009697:2680607:2680607 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 2680607, End: 2681776, Length: 1170

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2796000:2815265281526528164341170Clostridium botulinum F str. 230613 chromosome, complete genomemetallo-beta-lactamase family protein/flavodoxin0798
NC_010516:2777205:2798334279833427995031170Clostridium botulinum B1 str. Okra, complete genomemetallo-beta-lactamase family protein/flavodoxin0798
NC_010520:2807429:2829004282900428301731170Clostridium botulinum A3 str. Loch Maree, complete genomemetallo-beta-lactamase family protein/flavodoxin0797
NC_012563:2979147:2981666298166629828351170Clostridium botulinum A2 str. Kyoto, complete genomemetallo-beta-lactamase family protein/flavodoxin0796
NC_015425:906969:9239049239049250911188Clostridium botulinum BKT015925 chromosome, complete genomeflavodoxin9e-140496
NC_008593:841291:8602408602408614271188Clostridium novyi NT, complete genomeflavodoxin, putative4e-138491
NC_017294:71494:7615976159773761218Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomemetallo-beta-lactamase family flavodoxin1e-91337
NC_011059:1:4367436755901224Prosthecochloris aestuarii DSM 271, complete genomebeta-lactamase domain protein7e-87321
NC_002932:2142000:2150939215093921521651227Chlorobium tepidum TLS, complete genomerubredoxin:oxygen oxidoreductase, putative7e-87321
NC_011060:3000067:4331433155541224Pelodictyon phaeoclathratiforme BU-1, complete genomebeta-lactamase domain protein5e-83308
NC_018012:2327376:2327376232737623286651290Thiocystis violascens DSM 198 chromosome, complete genomeputative flavoprotein3e-76285
NC_014836:1052214:1071224107122410724351212Desulfurispirillum indicum S5 chromosome, complete genomeflavodoxin/nitric oxide synthase2e-73276
NC_018664:2638102:2653412265341226545991188Clostridium acidurici 9a chromosome, complete genomeanaerobic nitric oxide reductase flavorubredoxin NorV6e-65248
NC_010001:312500:3257773257773269401164Clostridium phytofermentans ISDg, complete genomebeta-lactamase domain protein1e-59230
NC_015562:436128:4437034437034448691167Methanotorris igneus Kol 5 chromosome, complete genomebeta-lactamase domain-containing protein5e-58225
NC_015636:1635400:1646222164622216474001179Methanothermococcus okinawensis IH1 chromosome, complete genomeflavodoxin/nitric oxide synthase3e-57223
NC_019978:416637:4272014272014284001200Halobacteroides halobius DSM 5150, complete genomeputative flavoprotein9e-57221
NC_013887:1402980:1411037141103714122091173Methanocaldococcus sp. FS406-22 chromosome, complete genomeflavodoxin/nitric oxide synthase2e-56220
NC_013156:980888:9877199877199888851167Methanocaldococcus fervens AG86, complete genomebeta-lactamase domain protein2e-56220
NC_014011:1354261:1356674135667413578431170Aminobacterium colombiense DSM 12261 chromosome, complete genomebeta-lactamase domain protein2e-56219
NC_019942:112182:1238701238701250571188Aciduliprofundum sp. MAR08-339, complete genomeputative flavoprotein8e-56218
NC_007604:1875268:1877025187702518787401716Synechococcus elongatus PCC 7942, complete genomeflavoprotein2e-55216
NC_006576:2423250:2438311243831124400261716Synechococcus elongatus PCC 6301, complete genomeflavoprotein3e-55216
NC_000909:657904:6642576642576654381182Methanocaldococcus jannaschii DSM 2661, complete genomeflavoprotein (fprA)4e-55215
NC_018867:2354000:2371056237105623722281173Dehalobacter sp. CF chromosome, complete genomerubredoxin-oxygen oxidoreductase4e-54212
NC_013926:829665:8371498371498383331185Aciduliprofundum boonei T469 chromosome, complete genomeflavodoxin/nitric oxide synthase5e-54211
NC_014377:210888:2120752120752132501176Thermosediminibacter oceani DSM 16646 chromosome, complete genomeflavodoxin/nitric oxide synthase9e-54211
NC_014926:1108811:1110280111028011114761197Thermovibrio ammonificans HB-1 chromosome, complete genomeflavodoxin/nitric oxide synthase1e-51204
NC_003413:694475:7026937026937038681176Pyrococcus furiosus DSM 3638, complete genomeflavoprotein3e-51202
NC_014365:3123853:3124914312491431261041191Desulfarculus baarsii DSM 2075 chromosome, complete genomeflavodoxin/nitric oxide synthase9e-51201
NC_011653:1574415:1593579159357915947451167Thermosipho africanus TCF52B, complete genomenitric oxide reductase7e-50198
NC_002937:2068117:2092404209240420935791176Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completemetallo-beta-lactamase family protein1e-49197
NC_011898:351792:3720683720683732581191Clostridium cellulolyticum H10, complete genomebeta-lactamase domain protein2e-49196
NC_014614:757381:7796047796047808031200Clostridium sticklandii, complete genomeBeta-lactamase domain protein3e-49196
NC_014618:1040381:1065069106506910665171449Enterobacter cloacae SCF1 chromosome, complete genomeflavodoxin/nitric oxide synthase3e-49196
NC_016629:3543432:3547352354735235485421191Desulfovibrio africanus str. Walvis Bay chromosome, completeflavodoxin/nitric oxide synthase4e-48192
NC_011729:1600056:1605973160597316076941722Cyanothece sp. PCC 7424 chromosome, complete genomeflavin reductase FMN-binding domain-containing protein9e-48191
NC_006513:286549:3102723102723129352664Azoarcus sp. EbN1, complete genomeanaerobic nitric oxide reductase flavorubredoxin2e-47190
NC_015379:2575000:2593877259387725953191443Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome,Anaerobic nitric oxide reductase flavorubredoxin2e-47189
NC_016830:4010637:4045870404587040473121443Pseudomonas fluorescens F113 chromosome, complete genomeprotein NorV2e-47189
NC_013517:4117666:4121817412181741230251209Sebaldella termitidis ATCC 33386, complete genomebeta-lactamase domain protein8e-47187
NC_009922:2323083:2323083232308323243031221Alkaliphilus oremlandii OhILAs, complete genomebeta-lactamase domain protein2e-46186
NC_014471:849032:8551808551808563671188Ignisphaera aggregans DSM 17230 chromosome, complete genomebeta-lactamase domain protein3e-45182
NC_014624:2912527:2913646291364629148331188Eubacterium limosum KIST612 chromosome, complete genomebeta-lactamase3e-45182
NC_008820:2512518:2515634251563425174091776Prochlorococcus marinus str. MIT 9303, complete genomeMetallo-beta-lactamase superfamily:Flavin reductase-like domain3e-45182
NC_007907:4714844:4735643473564347368331191Desulfitobacterium hafniense Y51, complete genomehypothetical protein6e-45181
NC_012780:284336:2996292996293007861158Eubacterium eligens ATCC 27750 plasmid unnamed, complete sequencehypothetical protein7e-45181
NC_000909:467607:4691164691164702911176Methanocaldococcus jannaschii DSM 2661, complete genomeflavoprotein (fprA)1e-43177
NC_015977:2718437:2741577274157727427851209Roseburia hominis A2-183 chromosome, complete genomeflavodoxin/nitric oxide synthase2e-43176
NC_014632:1248611:1269079126907912702871209Ilyobacter polytropus DSM 2926 chromosome, complete genomeflavodoxin/nitric oxide synthase6e-43175
NC_006576:2423250:2436341243634124380951755Synechococcus elongatus PCC 6301, complete genomeflavoprotein4e-39162
NC_007604:1875268:1878956187895618807101755Synechococcus elongatus PCC 7942, complete genomeflavoprotein4e-39162
NC_015737:664999:6786316786316798271197Clostridium sp. SY8519, complete genomeflavoprotein8e-39161
NC_016048:2167440:2174176217417621755281353Oscillibacter valericigenes Sjm18-20, complete genomeputative flavoprotein1e-38160
NC_019908:2401577:2429716242971624309271212Brachyspira pilosicoli P43/6/78 chromosome, complete genomeflavoprotein6e-37155
NC_013156:980888:9964129964129976501239Methanocaldococcus fervens AG86, complete genomebeta-lactamase domain protein1e-36154
NC_018607:2111581:2133197213319721344081212Brachyspira pilosicoli B2904 chromosome, complete genomeflavoprotein1e-36154
NC_012225:2523262:2533503253350325347171215Brachyspira hyodysenteriae WA1, complete genomeputative flavoprotein1e-36154
NC_014330:768232:7901777901777913881212Brachyspira pilosicoli 95/1000 chromosome, complete genomeputative flavoprotein1e-36154
NC_017243:2778427:2781352278135227825661215Brachyspira intermedia PWS/A chromosome, complete genomeflavoprotein9e-37154
NC_013887:1402980:1403962140396214052031242Methanocaldococcus sp. FS406-22 chromosome, complete genomeputative PAS/PAC sensor protein2e-36153
NC_014222:1:2142821428226451218Methanococcus voltae A3 chromosome, complete genomebeta-lactamase domain protein2e-35150
NC_012883:1695703:1704811170481117060371227Thermococcus sibiricus MM 739, complete genomeFlavoprotein, putative2e-34146
NC_000909:657904:6736846736846749341251Methanocaldococcus jannaschii DSM 2661, complete genomeflavoprotein (fpaA)3e-34145
NC_008698:435885:4583484583484595531206Thermofilum pendens Hrk 5, complete genomebeta-lactamase domain protein8e-34144
NC_003454:2080705:2088943208894320901601218Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeFlavoprotein1e-32140
NC_015680:755500:7772777772777785061230Pyrococcus yayanosii CH1 chromosome, complete genomeflavoprotein2e-32139
NC_000853:771746:7777047777047789001197Thermotoga maritima MSB8, complete genomehypothetical protein6e-31135
NC_013642:545464:5514225514225526181197Thermotoga naphthophila RKU-10, complete genomeflavodoxin/nitric oxide synthase2e-30133
NC_009486:155651:1693501693501705461197Thermotoga petrophila RKU-1 chromosome, complete genomeflavodoxin/nitric oxide synthase4e-30132
NC_015185:485866:4890684890684907111644Desulfurobacterium thermolithotrophum DSM 11699 chromosome,diguanylate cyclase9e-1065.1
NC_013939:212331:2274332274332291571725Deferribacter desulfuricans SSM1, complete genomehypothetical protein2e-0963.9
NC_013665:1392111:141353014135301413976447Methanocella paludicola SANAE, complete genomeputative flavodoxin2e-0963.5
NC_015474:723553:757469757469758236768Pyrococcus sp. NA2 chromosome, complete genomehypothetical protein1e-0654.7