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Query: NC_009567:904922:927554 Haemophilus influenzae PittGG chromosome, complete genome

Start: 927554, End: 928786, Length: 1233

Host Lineage: Haemophilus influenzae; Haemophilus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria

General Information: Strain PittGG is a non-typeable Haemophilus influenzae (NTHi) isolate recovered by Dr. Robert Wadowsky from the external ear discharge of a spontaneously perforated tympanic membrane of a child in Pittsburgh, USA who had been diagnosed with otorrhea. Causes respiratory tract infections primarily in children. A group of organisms that are either obligate parasites or commensal organisms found in animal mucous membranes. Almost all species require the presence of important growth factors found in the blood of their hosts, including either X factor (protoporphyrin IX or heme) or V factor (nicotinamide adenine dinucleotide (NAD or NADP)). This organism was first isolated in the 1890s during an influenza pandemic by Pfeiffer, and was originally thought to be the source of influenza, although later it was shown to be a secondary pathogen and may be synergistic with the influenza virus. This bacterium is one of the leading causes of meningitis in young children, and it may also cause septicemia, otitis media (inflammation of the middle ear), sinusitis (inflammation of the sinus cavity) and chronic bronchitis. It is highly adapted to its human host and typically lives in the nasopharynx and is a major cause of lower respiratory infections in infants and small children in developing countries (type 1b strain), although vaccine use has resulted in the decline of infections. The encapsulated organism can penetrate the blood and avoid both phagocytosis and complement-mediated lysis. All known strains produce neuraminidase and an IgA protease as well as fimbrial adhesins for attachment.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014922:825396:8258318258318270271197Haemophilus influenzae F3047 chromosome, complete genomeouter membrane integrity protein (tolA)5e-43175
NC_009053:313779:3342853342853355801296Actinobacillus pleuropneumoniae L20, complete genomecell envelope integrity inner membrane protein TolA5e-1789.4
NC_012214:2673058:2700292270029227016141323Erwinia pyrifoliae Ep1/96, complete genomehypothetical protein8e-1065.1
NC_015567:2125415:213645021364502136998549Serratia sp. AS9 chromosome, complete genomeTol-Pal system TolA3e-0963.2
NC_015566:2125403:213643821364382136986549Serratia sp. AS12 chromosome, complete genomeTol-Pal system TolA3e-0963.2
NC_009832:2211154:224325122432512243691441Serratia proteamaculans 568, complete genomeMembrane protein involved in colicin uptake-like protein1e-0758.2
CU928145:1773642:178479817847981785226429Escherichia coli 55989 chromosome, complete genomeputative TolA protein (fragment) of prophage1e-0757.8
NC_011748:1773642:178479817847981785226429Escherichia coli 55989, complete genomeputative TolA protein (fragment) of prophage1e-0757.8
NC_011415:1472500:149546214954621495890429Escherichia coli SE11 chromosome, complete genomehypothetical protein1e-0757.8
NC_015963:4500:590459046323420Enterobacter asburiae LF7a plasmid pENTAS01, complete sequenceTol-Pal system TolA1e-0655.1
NC_011205:839425:8394258394258406031179Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853cell envelope integrity inner membrane protein TolA2e-0654.3
NC_010102:2287934:2308292230829223094701179Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-0654.3
NC_011080:819103:8191038191038202811179Salmonella enterica subsp. enterica serovar Newport str. SL254,protein TolA2e-0654.3
NC_011083:862901:8629018629018640791179Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,protein TolA2e-0654.3
NC_016831:2209834:2229490222949022306681179Salmonella enterica subsp. enterica serovar Gallinarum/pullorumtolA protein2e-0654.3