Pre_GI: BLASTP Hits

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Query: NC_009565:3299937:3316752 Mycobacterium tuberculosis F11, complete genome

Start: 3316752, End: 3318008, Length: 1257

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3282405:3299224329922433004801257Mycobacterium tuberculosis RGTB327 chromosome, complete genomeTrans-acting enoyl reductase0719
NC_000962:3288464:3305279330527933065351257Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein0719
NC_002945:3246278:3261967326196732632231257Mycobacterium bovis AF2122/97, complete genomehypothetical protein0719
NC_008769:3242453:3259440325944032606961257Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0719
NC_009525:3300456:3317271331727133185271257Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein0719
NC_012207:3237440:3252267325226732535231257Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0719
NC_002755:3282785:3299600329960033008561257Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein0719
NC_016804:3221818:3238805323880532400611257Mycobacterium bovis BCG str. Mexico chromosome, complete genomeTrans-acting enoyl reductase0719
NC_015848:3343731:3361900336190033631561257Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein0716
NC_019950:3306419:3326209332620933274651257Mycobacterium canettii CIPT 140060008 complete genomePutative trans-acting enoyl reductase0716
NC_002677:173170:1731701731701744261257Mycobacterium leprae TN, complete genomehypothetical protein8e-178623
NC_011896:173197:1731971731971744531257Mycobacterium leprae Br4923, complete genomehypothetical protein8e-178623
NC_010612:4654936:4655640465564046568961257Mycobacterium marinum M, complete genomehypothetical protein2e-128459
NC_008541:4066294:4067228406722840684601233Arthrobacter sp. FB24 chromosome 1, complete sequenceSaccharopine dehydrogenase6e-67254
NC_008740:1635137:1653147165314716543881242Marinobacter aquaeolei VT8, complete genomeSaccharopine dehydrogenase2e-49197
NC_017506:1832443:1850088185008818513291242Marinobacter adhaerens HP15 chromosome, complete genomesaccharopine dehydrogenase-like protein5e-48192
NC_014960:1670778:1673710167371016747651056Anaerolinea thermophila UNI-1, complete genomesaccharopine dehydrogenase family protein3e-1273.2
NC_015957:7408466:7433212743321274342401029Streptomyces violaceusniger Tu 4113 chromosome, complete genomeSaccharopine dehydrogenase9e-1168.6
NC_020126:204216:2217962217962229141119Myxococcus stipitatus DSM 14675, complete genomehypothetical protein2e-1067.8
NC_009142:1701000:1717623171762317186721050Saccharopolyspora erythraea NRRL 2338, complete genomesaccharopine dehydrogenase2e-0963.9
NC_007908:4677856:4677856467785646789711116Rhodoferax ferrireducens T118, complete genomeSaccharopine dehydrogenase5e-0859.3
NC_004129:3965947:3967677396767739687561080Pseudomonas fluorescens Pf-5, complete genomehypothetical protein7e-0858.9
NC_012660:4669500:468146846814684682445978Pseudomonas fluorescens SBW25 chromosome, complete genomehypothetical protein1e-0758.2