Pre_GI: BLASTP Hits

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Query: NC_009565:3299937:3314576 Mycobacterium tuberculosis F11, complete genome

Start: 3314576, End: 3315721, Length: 1146

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015848:3343731:3359724335972433608691146Mycobacterium canettii CIPT 140010059, complete genomeputative oxidoreductase0738
NC_002755:3282785:3297424329742432985691146Mycobacterium tuberculosis CDC1551, complete genomeN5,N10-methylenetetrahydromethanopterin reductase-related protein0738
NC_009525:3300456:3315095331509533162401146Mycobacterium tuberculosis H37Ra, complete genomeN5,N10-methylenetetrahydromethanopterin reductase-related protein0738
NC_008769:3242453:3257264325726432584091146Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative oxidoreductase0738
NC_012207:3237440:3250091325009132512361146Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative oxidoreductase0738
NC_002945:3246278:3259791325979132609361146Mycobacterium bovis AF2122/97, complete genomeoxidoreductase0738
NC_000962:3288464:3303103330310333042481146Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE OXIDOREDUCTASE0738
NC_016804:3221818:3236629323662932377741146Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative oxidoreductase0738
NC_017026:3282405:3297048329704832981931146Mycobacterium tuberculosis RGTB327 chromosome, complete genomeoxidoreductase0738
NC_019950:3306419:3324033332403333251781146Mycobacterium canettii CIPT 140060008 complete genomePutative oxidoreductase0738
NC_002677:173170:1754411754411765891149Mycobacterium leprae TN, complete genomeputative oxidoreductase0644
NC_011896:173197:1754681754681766161149Mycobacterium leprae Br4923, complete genomeputative oxidoreductase0644
NC_014830:3438504:3463866346386634650021137Intrasporangium calvum DSM 43043 chromosome, complete genomeLuciferase-like, subgroup2e-44180
NC_013849:627811:645634645634646632999Ferroglobus placidus DSM 10642 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase3e-21103
NC_013849:19404:4081540815418311017Ferroglobus placidus DSM 10642 chromosome, complete genomeLuciferase-like, subgroup3e-21103
NC_015562:1299648:130121013012101302205996Methanotorris igneus Kol 5 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase5e-21102
NC_016948:1761020:1781064178106417822091146Mycobacterium intracellulare MOTT-64 chromosome, complete genomeluciferase family protein5e-21102
NC_016948:1761020:1786148178614817872871140Mycobacterium intracellulare MOTT-64 chromosome, complete genomeluciferase family protein2e-20100
NC_014122:143446:148423148423149418996Methanocaldococcus infernus ME chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase3e-1996.3
NC_017904:1831071:1854041185404118551771137Mycobacterium sp. MOTT36Y chromosome, complete genomeluciferase family protein5e-1995.9
NC_014253:2113233:213386221338622134848987Methanohalobium evestigatum Z-7303 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase1e-1790.9
NC_013407:146000:162714162714163709996Methanocaldococcus vulcanius M7, complete genome5,10-methylenetetrahydromethanopterin reductase2e-1687.4
NC_015574:1970967:198397119839711984936966Methanobacterium sp. SWAN-1 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase1e-1584.3
NC_003551:478065:4872644872644883131050Methanopyrus kandleri AV19, complete genomemethylenetetrahydromethanopterin reductase8e-1375.1
NC_009515:510121:522158522158523123966Methanobrevibacter smithii ATCC 35061, complete genomemethylenetetrahydromethanopterin reductase7e-1272
NC_013790:756000:758519758519759475957Methanobrevibacter ruminantium M1 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase Mer8e-1271.6
NC_008271:140846:159267159267160157891Rhodococcus sp. RHA1 plasmid pRHL3, complete sequencepossible hybride transferase/ F420-dependent dehydrogenase2e-0963.5
NC_017186:7480714:750030975003097501199891Amycolatopsis mediterranei S699 chromosome, complete genomeflavin-dependent oxidoreductase3e-0963.2
NC_014318:7480669:750026475002647501154891Amycolatopsis mediterranei U32 chromosome, complete genomeputative flavin-dependent oxidoreductase3e-0963.2
NC_008278:925231:939757939757940668912Frankia alni ACN14a, complete genomehypothetical protein9e-0961.6
NC_016906:1458158:147728314772831478281999Gordonia polyisoprenivorans VH2 chromosome, complete genomeputative F420-dependent oxidoreductase9e-0961.6
NC_013131:8480384:852485585248558525784930Catenulispora acidiphila DSM 44928, complete genomeLuciferase-like monooxygenase1e-0861.2
NC_012669:96966:116343116343117266924Beutenbergia cavernae DSM 12333, complete genomeLuciferase-like monooxygenase2e-0860.5
NC_014165:2888961:2906558290655829081891632Thermobispora bispora DSM 43833 chromosome, complete genomeluciferase-like monooxygenase2e-0860.5
NC_021177:7815791:783722278372227838139918Streptomyces fulvissimus DSM 40593, complete genomeHydride transferase 12e-0757.4
NC_013131:2517861:253478725347872535719933Catenulispora acidiphila DSM 44928, complete genomehypothetical protein2e-0757.4
NC_008268:2313583:2314567231456723155741008Rhodococcus sp. RHA1, complete genomeprobable 5,10-methylenetetrahydromethanopterin reductase2e-0757
NC_008271:35909:5945859458604651008Rhodococcus sp. RHA1 plasmid pRHL3, complete sequencepossible F420-dependent glucose-6-phosphate dehydrogenase3e-0756.6
NC_013523:2560000:2577966257796625790451080Sphaerobacter thermophilus DSM 20745 chromosome 1, complete genomeLuciferase-like monooxygenase4e-0756.2
NC_013510:3117837:3148924314892431499521029Thermomonospora curvata DSM 43183, complete genomeLuciferase-like monooxygenase4e-0756.2
NC_012522:2031786:2033292203329220342991008Rhodococcus opacus B4, complete genomeF420-dependent glucose-6-phosphate dehydrogenase6e-0755.8
NC_008271:140846:1615081615081625211014Rhodococcus sp. RHA1 plasmid pRHL3, complete sequenceprobable glucose-6-phosphate 1-dehydrogenase1e-0654.7
NC_014507:2196539:219954921995492200547999Methanoplanus petrolearius DSM 11571 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase1e-0654.3
NC_009921:565947:570804570804571682879Frankia sp. EAN1pec, complete genomeluciferase family protein3e-0653.1
NC_013159:2098500:2135470213547021365251056Saccharomonospora viridis DSM 43017, complete genomeflavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase5e-0652.4
NC_002677:332923:3530073530073540171011Mycobacterium leprae TN, complete genomeputative F420-dependent glucose-6-phosphate dehydrogenase8e-0651.6
NC_011896:332939:3530233530233540331011Mycobacterium leprae Br4923, complete genomeputative F420-dependent glucose-6-phosphate dehydrogenase8e-0651.6
NC_012669:96966:1135891135891146291041Beutenbergia cavernae DSM 12333, complete genomeLuciferase-like monooxygenase9e-0651.6