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Query: NC_009565:3299937:3311444 Mycobacterium tuberculosis F11, complete genome

Start: 3311444, End: 3312043, Length: 600

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3282405:329391632939163294515600Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein2e-113407
NC_002755:3282785:329429232942923294930639Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein3e-113407
NC_002945:3246278:325665932566593257258600Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-113407
NC_015848:3343731:335659233565923357191600Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein2e-113407
NC_009525:3300456:331196333119633312562600Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-113407
NC_019950:3306419:332090133209013321500600Mycobacterium canettii CIPT 140060008 complete genomeChorismate pyruvate lyase2e-113407
NC_012207:3237440:324695932469593247558600Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-113407
NC_008769:3242453:325413232541323254731600Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-113407
NC_000962:3288464:329997132999713300570600Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein2e-113407
NC_016804:3221818:323349732334973234096600Mycobacterium bovis BCG str. Mexico chromosome, complete genomechorismate--pyruvate lyase2e-113407
NC_002677:173170:179256179256179888633Mycobacterium leprae TN, complete genomehypothetical protein4e-66250
NC_011896:173197:179283179283179915633Mycobacterium leprae Br4923, complete genomehypothetical protein4e-66250
NC_010612:103081:114798114798115397600Mycobacterium marinum M, complete genome4-hydroxybenzoate synthetase (chorismate lyase)2e-42171
NC_020133:77341:814098140982128720Mycobacterium liflandii 128FXT, complete genome4-hydroxybenzoate synthetase1e-41169
NC_007796:1291671:1291671129167112932301560Methanospirillum hungatei JF-1, complete genomeGHMP kinase group 11e-0963.2