Pre_GI: BLASTP Hits

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Query: NC_009565:3299937:3302097 Mycobacterium tuberculosis F11, complete genome

Start: 3302097, End: 3302798, Length: 702

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_019950:3306419:331149033114903312191702Mycobacterium canettii CIPT 140060008 complete genomeConserved lipoprotein of unknown function, LppX9e-121432
NC_014168:1294000:132461113246111325342732Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein3e-43174
NC_002945:3246278:324719732471973247898702Mycobacterium bovis AF2122/97, complete genomelipoprotein LppX9e-121432
NC_002755:3282785:328494532849453285646702Mycobacterium tuberculosis CDC1551, complete genomelipoprotein, putative9e-121432
NC_000962:3288464:329062432906243291325702Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED LIPOPROTEIN LPPX9e-121432
NC_009525:3300456:330261633026163303317702Mycobacterium tuberculosis H37Ra, complete genomeputative conserved lipoprotein LppX9e-121432
NC_016804:3221818:322397832239783224679702Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative lipoprotein9e-121432
NC_006361:5146000:515248451524845153290807Nocardia farcinica IFM 10152, complete genomeputative lipoprotein2e-0756.2
NC_012207:3237440:323744032374403238141702Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative lipoprotein9e-121432
NC_011896:173197:188578188578189279702Mycobacterium leprae Br4923, complete genomeputative lipoprotein3e-88324
NC_002677:173170:188551188551189252702Mycobacterium leprae TN, complete genomeputative lipoprotein3e-88324
NC_017026:3282405:328456532845653285266702Mycobacterium tuberculosis RGTB327 chromosome, complete genomeputative lipoprotein LPPX9e-121432
NC_008769:3242453:324461332446133245314702Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative lipoprotein lppX9e-121432
NC_015848:3343731:334706733470673347768702Mycobacterium canettii CIPT 140010059, complete genomeputative lipoprotein LPPX9e-121432