Pre_GI: BLASTP Hits

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Query: NC_009565:3128094:3147968 Mycobacterium tuberculosis F11, complete genome

Start: 3147968, End: 3148237, Length: 270

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:3049631:306968130696813069950270Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-22104
NC_012207:3063039:308308930830893083358270Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-22104
NC_009525:3128786:314832231483223149047726Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein6e-22102
NC_019950:3139865:315941231594123159681270Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein1e-1995.1
NC_014666:1969602:197466419746641974927264Frankia sp. EuI1c chromosome, complete genomeProtein of unknown function DUF22778e-1268.9
NC_009380:2310000:232131923213192321588270Salinispora tropica CNB-440 chromosome, complete genomehypothetical protein5e-0753.1
NC_013739:2057781:207857520785752078844270Conexibacter woesei DSM 14684, complete genomeProtein of unknown function DUF22772e-0651.6
NC_013947:3406000:340855734085573408826270Stackebrandtia nassauensis DSM 44728 chromosome, complete genomehypothetical protein4e-0650.1