Pre_GI: BLASTP Hits

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Query: NC_009565:3128094:3128094 Mycobacterium tuberculosis F11, complete genome

Start: 3128094, End: 3128702, Length: 609

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:1279178:129685412968541297462609Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein4e-83306
NC_012943:1279228:129691012969101297518609Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein4e-83306
NC_017026:3110155:311015531101553110583429Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein3e-48191
NC_017904:2379387:242609724260972426543447Mycobacterium sp. MOTT36Y chromosome, complete genomehypothetical protein2e-37155
NC_002755:3110929:311092931109293111465537Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein7e-29126
NC_008726:610000:610160610160610759600Mycobacterium vanbaalenii PYR-1, complete genomeconserved hypothetical protein7e-27120
NC_008726:1776192:179294317929431793542600Mycobacterium vanbaalenii PYR-1, complete genomeconserved hypothetical protein7e-27120
NC_013235:2257899:226228522622852262878594Nakamurella multipartita DSM 44233, complete genomehypothetical protein2e-25115
NC_015635:2001539:201764220176422018259618Microlunatus phosphovorus NM-1, complete genomehypothetical protein2e-25115
NC_014814:4235477:425701542570154257635621Mycobacterium sp. Spyr1 chromosome, complete genomehypothetical protein1e-1996.7
NC_014814:2588628:259161625916162592236621Mycobacterium sp. Spyr1 chromosome, complete genomehypothetical protein1e-1996.7