Pre_GI: BLASTP Hits

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Query: NC_009565:2306574:2329437 Mycobacterium tuberculosis F11, complete genome

Start: 2329437, End: 2329673, Length: 237

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:2286000:230814623081462308382237Mycobacterium tuberculosis RGTB327 chromosome, complete genome50S ribosomal protein L281e-31134
NC_016804:2254979:227784222778422278078237Mycobacterium bovis BCG str. Mexico chromosome, complete genome50S ribosomal protein L281e-31134
NC_009142:827912:847058847058847294237Saccharopolyspora erythraea NRRL 2338, complete genome50S ribosomal protein L281e-1891.7
NC_013715:1907503:192891419289141929150237Rothia mucilaginosa DY-18, complete genomeribosomal protein L282e-1477.4
NC_013714:2086526:214895221489522149197246Bifidobacterium dentium Bd1, complete genome50S ribosomal protein L28,50S ribosomal protein L282e-1374.7
NC_007947:290864:307391307391307627237Methylobacillus flagellatus KT, complete genomeribosomal protein L283e-1270.5
NC_008260:228475:233902233902234138237Alcanivorax borkumensis SK2, complete genomeribosomal protein L283e-1270.5
NC_011901:342777:366972366972367208237Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, complete50S ribosomal protein L284e-1270.1
NC_016745:675909:678031678031678267237Oceanimonas sp. GK1 chromosome, complete genome50S ribosomal protein L285e-1269.7
NC_015422:3836911:385705038570503857283234Alicycliphilus denitrificans K601 chromosome, complete genome50S ribosomal protein L286e-1269.7
NC_008786:1936626:195706319570631957296234Verminephrobacter eiseniae EF01-2, complete genomeribosomal protein L287e-1269.3
NC_012968:381771:393023393023393259237Methylotenera mobilis JLW8, complete genomeribosomal protein L281e-1168.9
NC_007912:4661141:466349746634974663733237Saccharophagus degradans 2-40, complete genome50S ribosomal subunit protein L282e-1167.8
NC_017986:2548720:255411325541132554349237Pseudomonas putida ND6 chromosome, complete genome50S ribosomal protein L285e-1166.6
NC_013416:386301:398752398752398988237Aggregatibacter actinomycetemcomitans D11S-1, complete genome50S ribosomal protein L281e-1065.5
NC_012913:2189862:219413621941362194372237Aggregatibacter aphrophilus NJ8700, complete genomeribosomal protein L281e-1065.5
NC_018691:198909:203837203837204073237Alcanivorax dieselolei B5 chromosome, complete genome50S ribosomal protein L281e-1065.1
NC_013971:73037:103619103619103855237Erwinia amylovora ATCC 49946 chromosome, complete genome50S ribosomal protein L282e-1064.7
NC_013961:73037:103619103619103855237Erwinia amylovora, complete genome50S ribosomal protein L282e-1064.7
NC_004741:3992384:399326939932693993505237Shigella flexneri 2a str. 2457T, complete genome50S ribosomal protein L284e-1063.5
NC_009801:4108179:412737441273744127610237Escherichia coli E24377A, complete genomeribosomal protein L284e-1063.5
NC_004337:3761865:378175237817523781988237Shigella flexneri 2a str. 301, complete genome50S ribosomal protein L284e-1063.5
NC_011748:4167043:418646041864604186696237Escherichia coli 55989, complete genome50S ribosomal protein L284e-1063.5
NC_002695:4537000:455529745552974555533237Escherichia coli O157:H7 str. Sakai, complete genome50S ribosomal protein L284e-1063.5
NC_009800:3821824:384101938410193841255237Escherichia coli HS, complete genomeribosomal protein L284e-1063.5
NC_004337:3590323:378175237817523781988237Shigella flexneri 2a str. 301, complete genome50S ribosomal protein L284e-1063.5
NC_011750:4307166:432635843263584326594237Escherichia coli IAI39 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_008253:3896704:391590839159083916144237Escherichia coli 536, complete genome50S ribosomal protein L284e-1063.5
NC_010473:3883701:390703839070383907274237Escherichia coli str. K-12 substr. DH10B, complete genome50S ribosomal subunit protein L284e-1063.5
CU928145:4167043:418646041864604186696237Escherichia coli 55989 chromosome, complete genome50S ribosomal subunit protein L284e-1063.5
NC_010498:4031500:404945940494594049695237Escherichia coli SMS-3-5, complete genomeribosomal protein L284e-1063.5
NC_010658:3774110:379426037942603794496237Shigella boydii CDC 3083-94, complete genomeribosomal protein L284e-1063.5
NC_004431:4223232:424243642424364242672237Escherichia coli CFT073, complete genome50S ribosomal protein L284e-1063.5
CP002185:3998112:401730740173074017543237Escherichia coli W, complete genome50S ribosomal subunit protein L284e-1063.5
NC_002655:4606000:462428046242804624516237Escherichia coli O157:H7 EDL933, complete genome50S ribosomal protein L284e-1063.5
AP010958:4668181:466906646690664669302237Escherichia coli O103:H2 str. 12009 DNA, complete genome50S ribosomal subunit protein L284e-1063.5
NC_010468:80000:801018010180337237Escherichia coli ATCC 8739, complete genomeribosomal protein L284e-1063.5
CU928160:3862935:388212138821213882357237Escherichia coli IAI1 chromosome, complete genome50S ribosomal subunit protein L284e-1063.5
CP002516:88500:885308853088766237Escherichia coli KO11, complete genomeribosomal protein L284e-1063.5
NC_007946:4050762:406996640699664070202237Escherichia coli UTI89, complete genome50S ribosomal subunit protein L284e-1063.5
NC_011751:4251296:427071642707164270952237Escherichia coli UMN026 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_012967:3729813:374979337497933750029237Escherichia coli B str. REL606 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_013008:4595043:461444246144424614678237Escherichia coli O157:H7 str. TW14359 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_013353:4668181:466906646690664669302237Escherichia coli O103:H2 str. 12009, complete genome50S ribosomal protein L284e-1063.5
NC_013361:4991020:499190549919054992141237Escherichia coli O26:H11 str. 11368 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_013364:4460500:447883944788394479075237Escherichia coli O111:H- str. 11128, complete genome50S ribosomal protein L284e-1063.5
NC_013941:4427000:444524244452424445478237Escherichia coli O55:H7 str. CB9615 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_016822:4093000:409306840930684093304237Shigella sonnei 53G, complete genome50S ribosomal protein L284e-1063.5
NC_016902:88500:885308853088766237Escherichia coli KO11FL chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_017328:3794105:381395238139523814188237Shigella flexneri 2002017 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_012759:3675396:369778736977873698023237Escherichia coli BW2952 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_011745:4226186:424560242456024245838237Escherichia coli ED1a chromosome, complete genome50S ribosomal protein L284e-1063.5
AC_000091:3827856:382874138287413828977237Escherichia coli W3110 DNA, complete genome50S ribosomal subunit protein L284e-1063.5
NC_000913:3786124:380946138094613809697237Escherichia coli K12, complete genome50S ribosomal protein L284e-1063.5
NC_011740:4007000:402814940281494028385237Escherichia fergusonii ATCC 35469, complete genome50S ribosomal subunit protein L284e-1063.5
NC_007606:3784847:380370738037073803943237Shigella dysenteriae Sd197, complete genome50S ribosomal subunit protein L284e-1063.5
NC_011353:4639002:465840146584014658637237Escherichia coli O157:H7 str. EC4115 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_011415:4040211:405962840596284059864237Escherichia coli SE11 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_011601:4036590:405780840578084058044237Escherichia coli O127:H6 str. E2348/69 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_011741:3862935:388212138821213882357237Escherichia coli IAI1 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_011742:3998285:401748940174894017725237Escherichia coli S88 chromosome, complete genome50S ribosomal protein L284e-1063.5
NC_011080:3875320:389537738953773895613237Salmonella enterica subsp. enterica serovar Newport str. SL254,ribosomal protein L285e-1063.2
NC_006511:3690828:371088537108853711121237Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC50S ribosomal protein L285e-1063.2
NC_006905:3845000:386452638645263864762237Salmonella enterica subsp. enterica serovar Choleraesuis str50S ribosomal protein L285e-1063.2
NC_011149:3822000:384159338415933841829237Salmonella enterica subsp. enterica serovar Agona str. SL483,ribosomal protein L285e-1063.2
NC_003198:3924952:392583539258353926071237Salmonella enterica subsp. enterica serovar Typhi str. CT18,50S ribosomal protein L285e-1063.2
NC_004631:3910451:391133439113343911570237Salmonella enterica subsp. enterica serovar Typhi Ty2, complete50S ribosomal protein L285e-1063.2
NC_003197:3902500:392222639222263922462237Salmonella typhimurium LT2, complete genome50S ribosomal protein L285e-1063.2
NC_011083:3915500:393523639352363935472237Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,ribosomal protein L285e-1063.2
NC_011094:3778000:379831237983123798548237Salmonella enterica subsp. enterica serovar Schwarzengrund str50S ribosomal protein L285e-1063.2
NC_011147:3686500:370655537065553706791237Salmonella enterica subsp. enterica serovar Paratyphi A str50S ribosomal protein L285e-1063.2
NC_011205:3942500:396192739619273962163237Salmonella enterica subsp. enterica serovar Dublin str. CT_0202185350S ribosomal protein L285e-1063.2
NC_016863:3864000:388352538835253883761237Salmonella enterica subsp. enterica serovar Typhimurium str. UK-150S ribosomal protein L285e-1063.2
NC_016860:3925500:394512239451223945358237Salmonella enterica subsp. enterica serovar Typhimurium str50S ribosomal protein L285e-1063.2
NC_016857:3924000:394354139435413943777237Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/7450S ribosomal protein L285e-1063.2
NC_016856:3916500:393591839359183936154237Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S50S ribosomal protein L285e-1063.2
NC_016810:3923988:394354039435403943776237Salmonella enterica subsp. enterica serovar Typhimurium str50S ribosomal protein L285e-1063.2
NC_012125:3840000:385938138593813859617237Salmonella enterica subsp. enterica serovar Paratyphi C strain50S ribosomal protein L285e-1063.2
NC_011294:3782655:380333038033303803566237Salmonella enterica subsp. enterica serovar Enteritidis str50S ribosomal protein L285e-1063.2
NC_011274:3894387:389527038952703895506237Salmonella enterica subsp. enterica serovar Gallinarum str. 287/9150S ribosomal protein L285e-1063.2
NC_013421:4790696:481174548117454811981237Pectobacterium wasabiae WPP163, complete genomeribosomal protein L289e-1062.4
NC_013850:109500:128052128052128288237Klebsiella variicola At-22 chromosome, complete genomeribosomal protein L289e-1062.4
NC_011283:105245:122856122856123092237Klebsiella pneumoniae 342 chromosome, complete genome50S ribosomal protein L289e-1062.4
NC_004547:164000:167881167881168117237Erwinia carotovora subsp. atroseptica SCRI1043, complete genome50S ribosomal protein L288e-1062.4
NC_016816:127802:147302147302147538237Pantoea ananatis LMG 5342, complete genome50S ribosomal protein L281e-0962
NC_007613:3637832:365703636570363657272237Shigella boydii Sb227, complete genome50S ribosomal subunit protein L282e-0961.6
NC_018507:115346:122728122728122943216Candidatus Portiera aleyrodidarum BT-B chromosome, complete genome50S ribosomal protein L282e-0858.2
NC_018677:111500:116295116295116510216Candidatus Portiera aleyrodidarum BT-B-HRs chromosome, completeLSU ribosomal protein L28p2e-0858.2
NC_010830:718614:735533735533735784252Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein2e-0754.3
NC_016845:5162481:516248151624815162681201Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,50S ribosomal protein L284e-0650.1
NC_017046:3923000:394236739423673942567201Salmonella enterica subsp. enterica serovar Typhimurium str. 79850S ribosomal protein L285e-0649.7
NC_016832:3900000:390016739001673900367201Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,50S ribosomal protein L285e-0649.7
NC_016831:3875134:387605338760533876253201Salmonella enterica subsp. enterica serovar Gallinarum/pullorum50S ribosomal protein L285e-0649.7
NC_010102:3851500:387117338711733871373201Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein5e-0649.7
NC_016513:689689:702141702141702314174Aggregatibacter actinomycetemcomitans ANH9381 chromosome, complete50S ribosomal protein L285e-0649.7