Pre_GI: BLASTP Hits

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Query: NC_009565:2306574:2329273 Mycobacterium tuberculosis F11, complete genome

Start: 2329273, End: 2329437, Length: 165

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:2286000:230798223079822308146165Mycobacterium tuberculosis RGTB327 chromosome, complete genome50S ribosomal protein L331e-23108
NC_016804:2254979:227767822776782277842165Mycobacterium bovis BCG str. Mexico chromosome, complete genome50S ribosomal protein L331e-23108
NC_018750:2696000:271268927126892712853165Streptomyces venezuelae ATCC 10712, complete genomeLSU ribosomal protein L33p5e-1992.8
NC_013715:1907503:192874019287401928910171Rothia mucilaginosa DY-18, complete genomeribosomal protein L337e-1992.4
NC_009142:827912:846894846894847058165Saccharopolyspora erythraea NRRL 2338, complete genome50S ribosomal protein L333e-1890.1
NC_013714:2086526:214876621487662148933168Bifidobacterium dentium Bd1, complete genome50S ribosomal protein L331e-1375.5
NC_015161:927152:933370933370933537168Deinococcus proteolyticus MRP chromosome, complete genome50S ribosomal protein L331e-1168.6
NC_016745:675909:678279678279678449171Oceanimonas sp. GK1 chromosome, complete genome50S ribosomal protein L337e-1062.4
NC_011901:342777:366792366792366959168Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, complete50S ribosomal protein L338e-1062.4
NC_013850:109500:128309128309128476168Klebsiella variicola At-22 chromosome, complete genomeribosomal protein L332e-0961.2
NC_011283:105245:123113123113123280168Klebsiella pneumoniae 342 chromosome, complete genome50S ribosomal protein L332e-0961.2
CP002185:3998112:401711940171194017286168Escherichia coli W, complete genome50S ribosomal subunit protein L332e-0960.8
NC_004431:4223232:424224842422484242415168Escherichia coli CFT073, complete genome50S ribosomal protein L332e-0960.8
NC_000913:3786124:380927338092733809440168Escherichia coli K12, complete genome50S ribosomal protein L332e-0960.8
NC_006905:3845000:386433838643383864505168Salmonella enterica subsp. enterica serovar Choleraesuis str50S ribosomal protein L332e-0960.8
NC_011748:4167043:418627241862724186439168Escherichia coli 55989, complete genome50S ribosomal protein L332e-0960.8
NC_008253:3896704:391572039157203915887168Escherichia coli 536, complete genome50S ribosomal protein L332e-0960.8
NC_010658:3774110:379407237940723794239168Shigella boydii CDC 3083-94, complete genomeribosomal protein L332e-0960.8
NC_011751:4251296:427052842705284270695168Escherichia coli UMN026 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_006511:3690828:371069737106973710864168Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC50S ribosomal protein L332e-0960.8
NC_004337:3590323:378156437815643781731168Shigella flexneri 2a str. 301, complete genome50S ribosomal protein L332e-0960.8
NC_002695:4537000:455510945551094555276168Escherichia coli O157:H7 str. Sakai, complete genome50S ribosomal protein L332e-0960.8
NC_010067:3846962:384696238469623847129168Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein2e-0960.8
NC_010468:80000:803588035880525168Escherichia coli ATCC 8739, complete genomeribosomal protein L332e-0960.8
AC_000091:3827856:382899838289983829165168Escherichia coli W3110 DNA, complete genome50S ribosomal subunit protein L332e-0960.8
NC_009801:4108179:412718641271864127353168Escherichia coli E24377A, complete genomeribosomal protein L332e-0960.8
NC_008258:3995553:399665639966563996823168Shigella flexneri 5 str. 8401, complete genome50S ribosomal subunit protein L332e-0960.8
NC_004631:3910451:391159139115913911758168Salmonella enterica subsp. enterica serovar Typhi Ty2, complete50S ribosomal protein L332e-0960.8
NC_011083:3915500:393504839350483935215168Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,ribosomal protein L332e-0960.8
NC_007613:3637832:365684836568483657015168Shigella boydii Sb227, complete genome50S ribosomal subunit protein L332e-0960.8
NC_010473:3883701:390685039068503907017168Escherichia coli str. K-12 substr. DH10B, complete genome50S ribosomal subunit protein L332e-0960.8
NC_011750:4307166:432617043261704326337168Escherichia coli IAI39 chromosome, complete genome50S ribosomal protein L332e-0960.8
CU928160:3862935:388193338819333882100168Escherichia coli IAI1 chromosome, complete genome50S ribosomal subunit protein L332e-0960.8
NC_004741:3992384:399352639935263993693168Shigella flexneri 2a str. 2457T, complete genome50S ribosomal protein L332e-0960.8
NC_010102:3851500:387098538709853871152168Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-0960.8
NC_009800:3821824:384083138408313840998168Escherichia coli HS, complete genomeribosomal protein L332e-0960.8
AP010958:4668181:466932346693234669490168Escherichia coli O103:H2 str. 12009 DNA, complete genome50S ribosomal subunit protein L332e-0960.8
NC_007384:3956465:395646539564653956632168Shigella sonnei Ss046, complete genome50S ribosomal subunit protein L332e-0960.8
NC_002655:4606000:462409246240924624259168Escherichia coli O157:H7 EDL933, complete genome50S ribosomal protein L332e-0960.8
NC_007946:4050762:406977840697784069945168Escherichia coli UTI89, complete genome50S ribosomal subunit protein L332e-0960.8
NC_010498:4031500:404927140492714049438168Escherichia coli SMS-3-5, complete genomeribosomal protein L332e-0960.8
NC_011080:3875320:389518938951893895356168Salmonella enterica subsp. enterica serovar Newport str. SL254,ribosomal protein L332e-0960.8
NC_011149:3822000:384140538414053841572168Salmonella enterica subsp. enterica serovar Agona str. SL483,ribosomal protein L332e-0960.8
NC_009792:4658909:467653546765354676702168Citrobacter koseri ATCC BAA-895, complete genomehypothetical protein2e-0960.8
CP002516:88500:887878878788954168Escherichia coli KO11, complete genomeribosomal protein L332e-0960.8
CU928145:4167043:418627241862724186439168Escherichia coli 55989 chromosome, complete genome50S ribosomal subunit protein L332e-0960.8
NC_003198:3924952:392609239260923926259168Salmonella enterica subsp. enterica serovar Typhi str. CT18,50S ribosomal protein L332e-0960.8
NC_004337:3761865:378156437815643781731168Shigella flexneri 2a str. 301, complete genome50S ribosomal protein L332e-0960.8
NC_017328:3794105:381376438137643813931168Shigella flexneri 2002017 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_013361:4991020:499216249921624992329168Escherichia coli O26:H11 str. 11368 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_013364:4460500:447865144786514478818168Escherichia coli O111:H- str. 11128, complete genome50S ribosomal protein L332e-0960.8
NC_013941:4427000:444505444450544445221168Escherichia coli O55:H7 str. CB9615 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_013971:73037:103872103872104039168Erwinia amylovora ATCC 49946 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_015761:3611993:363187836318783632045168Salmonella bongori NCTC 12419, complete genome50S ribosomal subunit protein L332e-0960.8
NC_016810:3923988:394335239433523943519168Salmonella enterica subsp. enterica serovar Typhimurium str50S ribosomal protein L332e-0960.8
NC_016816:127802:147559147559147726168Pantoea ananatis LMG 5342, complete genome50S ribosomal protein L332e-0960.8
NC_016822:4093000:409332540933254093492168Shigella sonnei 53G, complete genome50S ribosomal protein L332e-0960.8
NC_016831:3875134:387627438762743876441168Salmonella enterica subsp. enterica serovar Gallinarum/pullorum50S ribosomal protein L332e-0960.8
NC_016832:3900000:390038839003883900555168Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,hypothetical protein2e-0960.8
NC_016856:3916500:393573039357303935897168Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S50S ribosomal protein L332e-0960.8
NC_016857:3924000:394335339433533943520168Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/7450S ribosomal protein L332e-0960.8
NC_016860:3925500:394493439449343945101168Salmonella enterica subsp. enterica serovar Typhimurium str50S ribosomal protein L332e-0960.8
NC_016863:3864000:388333738833373883504168Salmonella enterica subsp. enterica serovar Typhimurium str. UK-150S ribosomal protein L332e-0960.8
NC_016902:88500:887878878788954168Escherichia coli KO11FL chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_017046:3923000:394217939421793942346168Salmonella enterica subsp. enterica serovar Typhimurium str. 79850S ribosomal protein L332e-0960.8
NC_013353:4668181:466932346693234669490168Escherichia coli O103:H2 str. 12009, complete genome50S ribosomal protein L332e-0960.8
NC_013008:4595043:461425446142544614421168Escherichia coli O157:H7 str. TW14359 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_012967:3729813:374960537496053749772168Escherichia coli B str. REL606 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_007606:3784847:380351938035193803686168Shigella dysenteriae Sd197, complete genome50S ribosomal subunit protein L332e-0960.8
NC_013961:73037:103872103872104039168Erwinia amylovora, complete genome50S ribosomal protein L332e-0960.8
NC_011740:4007000:402796140279614028128168Escherichia fergusonii ATCC 35469, complete genome50S ribosomal subunit protein L332e-0960.8
NC_003197:3902500:392203839220383922205168Salmonella typhimurium LT2, complete genome50S ribosomal protein L332e-0960.8
NC_011094:3778000:379812437981243798291168Salmonella enterica subsp. enterica serovar Schwarzengrund str50S ribosomal protein L332e-0960.8
NC_011147:3686500:370637437063743706541168Salmonella enterica subsp. enterica serovar Paratyphi A str50S ribosomal protein L332e-0960.8
NC_011205:3942500:396173939617393961906168Salmonella enterica subsp. enterica serovar Dublin str. CT_0202185350S ribosomal protein L332e-0960.8
NC_011274:3894387:389552738955273895694168Salmonella enterica subsp. enterica serovar Gallinarum str. 287/9150S ribosomal protein L332e-0960.8
NC_011294:3782655:380314238031423803309168Salmonella enterica subsp. enterica serovar Enteritidis str50S ribosomal protein L332e-0960.8
NC_011353:4639002:465821346582134658380168Escherichia coli O157:H7 str. EC4115 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_011415:4040211:405944040594404059607168Escherichia coli SE11 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_011601:4036590:405762040576204057787168Escherichia coli O127:H6 str. E2348/69 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_011741:3862935:388193338819333882100168Escherichia coli IAI1 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_011742:3998285:401730140173014017468168Escherichia coli S88 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_011745:4226186:424541442454144245581168Escherichia coli ED1a chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_012125:3840000:385919338591933859360168Salmonella enterica subsp. enterica serovar Paratyphi C strain50S ribosomal protein L332e-0960.8
NC_012759:3675396:369759936975993697766168Escherichia coli BW2952 chromosome, complete genome50S ribosomal protein L332e-0960.8
NC_013421:4790696:481156648115664811733168Pectobacterium wasabiae WPP163, complete genomeribosomal protein L333e-0960.5
NC_004547:164000:168129168129168296168Erwinia carotovora subsp. atroseptica SCRI1043, complete genome50S ribosomal protein L333e-0960.5
NC_017986:2548720:255394625539462554101156Pseudomonas putida ND6 chromosome, complete genome50S ribosomal protein L337e-0959.3
NC_016513:689689:701959701959702129171Aggregatibacter actinomycetemcomitans ANH9381 chromosome, complete50S ribosomal protein L332e-0858.2
NC_012913:2189862:219438421943842194554171Aggregatibacter aphrophilus NJ8700, complete genomeribosomal protein L332e-0858.2
NC_013416:386301:398570398570398740171Aggregatibacter actinomycetemcomitans D11S-1, complete genomehypothetical protein2e-0858.2
NC_018145:1089548:110645011064501106617168Zymomonas mobilis subsp. mobilis ATCC 29191 chromosome, complete50S ribosomal protein L332e-0857.8
NC_012968:381771:392831392831392986156Methylotenera mobilis JLW8, complete genomeribosomal protein L333e-0857.4
NC_007947:290864:307225307225307380156Methylobacillus flagellatus KT, complete genomeribosomal protein L334e-0856.6
NC_008260:228475:234161234161234328168Alcanivorax borkumensis SK2, complete genomeribosomal protein L335e-0856.6
NC_015186:36502:381403814038307168Acidiphilium multivorum AIU301, complete genome50S ribosomal protein L338e-0855.8
NC_008786:1936626:195687219568721957042171Verminephrobacter eiseniae EF01-2, complete genomeribosomal protein L331e-0755.1
NC_007912:4661141:466376246637624663917156Saccharophagus degradans 2-40, complete genome50S ribosomal protein L331e-0755.1
NC_017059:31564:630236302363190168Rhodospirillum photometricum DSM 122, complete genome50S ribosomal protein L335e-0753.1
NC_015422:3836911:385730438573043857474171Alicycliphilus denitrificans K601 chromosome, complete genome50S ribosomal protein L337e-0752.8
NC_013510:4960500:496065149606514960815165Thermomonospora curvata DSM 43183, complete genomeribosomal protein L338e-0752.4
NC_018691:198909:204085204085204252168Alcanivorax dieselolei B5 chromosome, complete genome50S ribosomal protein L331e-0652
NC_018507:115346:122960122960123109150Candidatus Portiera aleyrodidarum BT-B chromosome, complete genome50S ribosomal protein L332e-0650.8
NC_018677:111500:116527116527116676150Candidatus Portiera aleyrodidarum BT-B-HRs chromosome, completeLSU ribosomal protein L33p zinc-independent2e-0650.8
NC_016109:3591401:361664936166493616813165Kitasatospora setae KM-6054, complete genome50S ribosomal protein L335e-0649.7
NC_015957:639774:659436659436659600165Streptomyces violaceusniger Tu 4113 chromosome, complete genome50S ribosomal protein L338e-0649.3