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Query: NC_009565:1629780:1647121 Mycobacterium tuberculosis F11, complete genome

Start: 1647121, End: 1647906, Length: 786

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:2764000:276687027668702767655786Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeantibiotic-transport membrane ABC transporter2e-110399
NC_002945:1621765:163928316392831640068786Mycobacterium bovis AF2122/97, complete genomeunidentified antibiotic-transport integral membrane ABC transporter2e-110399
NC_015848:1647523:166663716666371667422786Mycobacterium canettii CIPT 140010059, complete genomeputative unidentified antibiotic-transport integral membrane ABC transporter2e-110398
NC_012522:7596039:762496576249657625759795Rhodococcus opacus B4, complete genomeputative ABC transporter permease protein3e-58225
NC_002935:1237585:130840513084051309202798Corynebacterium diphtheriae NCTC 13129, complete genomehypothetical protein3e-30132
NC_016799:1268706:133755013375501338347798Corynebacterium diphtheriae 31A chromosome, complete genomehypothetical protein5e-30131
NC_016800:1243000:131066213106621311459798Corynebacterium diphtheriae BH8 chromosome, complete genomehypothetical protein4e-30131
NC_016782:1251796:128209412820941282891798Corynebacterium diphtheriae 241 chromosome, complete genomehypothetical protein4e-30131
NC_016783:1274000:130639413063941307191798Corynebacterium diphtheriae INCA 402 chromosome, complete genomehypothetical protein4e-30131
NC_016786:1251765:128206312820631282860798Corynebacterium diphtheriae HC01 chromosome, complete genomehypothetical protein4e-30131
NC_016787:1240000:127151312715131272310798Corynebacterium diphtheriae HC03 chromosome, complete genomehypothetical protein4e-30131
NC_016788:1214026:128150412815041282301798Corynebacterium diphtheriae HC04 chromosome, complete genomehypothetical protein4e-30131
NC_016790:1218596:124889212488921249689798Corynebacterium diphtheriae VA01 chromosome, complete genomehypothetical protein4e-30131
NC_016802:1256287:128299512829951283792798Corynebacterium diphtheriae HC02 chromosome, complete genomehypothetical protein4e-30131
NC_014643:2056280:210771921077192108549831Rothia dentocariosa ATCC 17931 chromosome, complete genomeABC transporter2e-27123
NC_013526:530212:544312544312545037726Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomeABC-2 type transporter3e-22105