Pre_GI: BLASTP Hits

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Query: NC_009565:1098847:1118061 Mycobacterium tuberculosis F11, complete genome

Start: 1118061, End: 1118492, Length: 432

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:1095846:111506111150611115492432Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein4e-75279
NC_002945:1095337:111474411147441115175432Mycobacterium bovis AF2122/97, complete genomehypothetical protein4e-75279
NC_009525:1096386:111560111156011116032432Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-75279
NC_008769:1125567:114478211447821145213432Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein4e-75279
NC_000962:1095078:111429311142931114724432Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein4e-75279
NC_012207:1097228:111644311164431116874432Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein4e-75279
NC_015848:1105892:112509411250941125525432Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein3e-74276
NC_002755:1095105:111449911144991114762264Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein1e-40164