Pre_GI: BLASTP Hits

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Query: NC_009565:1098847:1117629 Mycobacterium tuberculosis F11, complete genome

Start: 1117629, End: 1117880, Length: 252

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1095753:111455011145501114801252Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein3e-43173
NC_016804:1095846:111462911146291114880252Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein3e-43173
NC_002755:1095105:111389911138991114150252Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein3e-43173
NC_008769:1125567:114435011443501144601252Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein3e-43173
NC_009525:1096386:111516911151691115420252Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein3e-43173
NC_012207:1097228:111601111160111116262252Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein3e-43173