Pre_GI: BLASTP Hits

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Query: NC_009565:1098847:1116053 Mycobacterium tuberculosis F11, complete genome

Start: 1116053, End: 1117228, Length: 1176

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002755:1095105:1112324111232411134991176Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein9e-157553
NC_017026:1095753:1113073111307311141491077Mycobacterium tuberculosis RGTB327 chromosome, complete genometransmembrane protein6e-136484
NC_000962:1095078:1112384111238411134601077Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED TRANSMEMBRANE PROTEIN6e-136484
NC_009525:1096386:1113692111369211147681077Mycobacterium tuberculosis H37Ra, complete genomeputative conserved transmembrane protein6e-136484
NC_008769:1125567:1142873114287311439491077Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane protein1e-135483
NC_012207:1097228:1114534111453411156101077Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane protein1e-135483
NC_016804:1095846:1113152111315211142281077Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane protein1e-135483
NC_002945:1095337:1112835111283511139111077Mycobacterium bovis AF2122/97, complete genometransmembrane protein5e-135481
NC_015848:1105892:1123191112319111242611071Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein9e-134476
NC_006361:5146000:5167960516796051692701311Nocardia farcinica IFM 10152, complete genomehypothetical protein2e-1377.4
NC_014168:471000:483862483862484824963Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein9e-0858.2
NC_017186:9120711:914870191487019149540840Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein1e-0551.6