Pre_GI: BLASTP Hits

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Query: NC_009565:1098847:1104794 Mycobacterium tuberculosis F11, complete genome

Start: 1104794, End: 1105249, Length: 456

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1095753:110170511017051102160456Mycobacterium tuberculosis RGTB327 chromosome, complete genomelarge-conductance mechanosensitive channel4e-81299
NC_016768:3296478:330722133072213307676456Mycobacterium tuberculosis KZN 4207 chromosome, complete genomelarge-conductance ion mechanosensitive channel mscL4e-81299
NC_012943:3299744:331048733104873310942456Mycobacterium tuberculosis KZN 1435 chromosome, complete genomelarge-conductance mechanosensitive channel4e-81299
NC_000962:1095078:110102511010251101480456Mycobacterium tuberculosis H37Rv, complete genomelarge-conductance mechanosensitive channel4e-81299
NC_002755:1095105:110106411010641101519456Mycobacterium tuberculosis CDC1551, complete genomelarge-conductance mechanosensitive channel4e-81299
NC_002945:1095337:110147611014761101931456Mycobacterium bovis AF2122/97, complete genomelarge-conductance mechanosensitive channel4e-81299
NC_009525:1096386:110233311023331102788456Mycobacterium tuberculosis H37Ra, complete genomelarge-conductance mechanosensitive channel4e-81299
NC_015848:1105892:111183211118321112287456Mycobacterium canettii CIPT 140010059, complete genomeputative large-conductance ion mechanosensitive channel MSCL1e-80297
NC_008769:1125567:113151411315141131969456Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative large-conductance ion mechanosensitive channel mscL3e-80296
NC_012207:1097228:110317511031751103630456Mycobacterium bovis BCG str. Tokyo 172, complete genomelarge-conductance mechanosensitive channel3e-80296
NC_016804:1095846:110179311017931102248456Mycobacterium bovis BCG str. Mexico chromosome, complete genomeLarge-conductance mechanosensitive channel3e-80296
NC_017186:9120711:915435891543589154774417Amycolatopsis mediterranei S699 chromosome, complete genomelarge conductance mechanosensitive channel, MscL family protein1e-22105
NC_010407:32960:438054380544287483Clavibacter michiganensis subsp. sepedonicus chromosome, completeputative mechanosensitive channel8e-2095.9
NC_015145:2942500:294651629465162946926411Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomelarge conductance mechanosensitive channel protein3e-1994.4
NC_007777:75885:886998869989094396Frankia sp. CcI3, complete genomelarge conductance mechanosensitive channel protein3e-1994
NC_013595:9547254:955105695510569551460405Streptosporangium roseum DSM 43021, complete genomelarge conductance mechanosensitive channel protein4e-1890.1
NC_010320:1860801:186132418613241861704381Thermoanaerobacter sp. X514 chromosome, complete genomelarge conductance mechanosensitive channel protein6e-1786.3
NC_014538:1075720:109264010926401093020381Thermoanaerobacter sp. X513 chromosome, complete genomelarge conductance mechanosensitive channel protein6e-1786.3
NC_008541:3282415:328640832864083286800393Arthrobacter sp. FB24 chromosome 1, complete sequencelarge conductance mechanosensitive channel protein7e-1785.9
NC_011886:2950411:295657929565792956968390Arthrobacter chlorophenolicus A6, complete genomelarge conductance mechanosensitive channel protein1e-1685.1
NC_013510:991827:100630710063071006711405Thermomonospora curvata DSM 43183, complete genomelarge conductance mechanosensitive channel protein2e-1684.7
NC_014209:1392115:140480614048061405174369Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,large conductance mechanosensitive channel protein6e-1683.2
NC_010321:947233:962410962410962778369Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completelarge conductance mechanosensitive channel protein2e-1581.3
NC_014964:923681:954603954603954971369Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completelarge conductance mechanosensitive channel protein2e-1581.3
NC_013656:2382000:239589923958992396267369Lactococcus lactis subsp. lactis KF147, complete genomelarge-conductance mechanosensitive channel6e-1579.7
NC_015759:1117122:113952211395221139905384Weissella koreensis KACC 15510 chromosome, complete genomelarge conductance mechanosensitive channel protein1e-1479
NC_018750:3315309:332050733205073321115609Streptomyces venezuelae ATCC 10712, complete genomeLarge-conductance mechanosensitive channel1e-1479
NC_013174:2163947:216573421657342166132399Jonesia denitrificans DSM 20603, complete genomelarge conductance mechanosensitive channel protein9e-1579
NC_010161:596034:601845601845602255411Bartonella tribocorum CIP 105476, complete genomehypothetical protein9e-1579
NC_013508:3387272:338879633887963389203408Edwardsiella tarda EIB202, complete genomelarge-conductance mechanosensitive channel2e-1477.8
NC_008618:10915:124521245212895444Bifidobacterium adolescentis ATCC 15703, complete genomelarge-conductance mechanosensitive channel2e-1477.8
NC_015846:493388:518074518074518454381Capnocytophaga canimorsus Cc5 chromosome, complete genomeLarge-conductance mechanosensitive channel5e-1476.6
NC_008254:102465:118021118021118449429Mesorhizobium sp. BNC1, complete genomelarge conductance mechanosensitive channel protein1e-1375.5
NC_013282:3962188:398294739829473983354408Cronobacter turicensis, complete genomeLarge-conductance mechanosensitive channel2e-1374.7
NC_013171:1364464:138535613853561385766411Anaerococcus prevotii DSM 20548, complete genomelarge conductance mechanosensitive channel protein2e-1374.3
NC_002678:3701500:373064737306473731081435Mesorhizobium loti MAFF303099, complete genomemechanosensitive channel7e-1372.8
CP002185:3627992:365099336509933651403411Escherichia coli W, complete genomemechanosensitive channel4e-1270.5
NC_002678:3701500:374379037437903744212423Mesorhizobium loti MAFF303099, complete genomelarge conductance mechanosensitive channel6e-1269.7
NC_015684:2369651:236965123696512370067417Oligotropha carboxidovorans OM5 chromosome, complete genomelarge-conductance mechanosensitive channel MscL8e-1269.3
NC_012467:916000:932535932535932912378Streptococcus pneumoniae P1031, complete genomelarge conductance mechanosensitive channel protein2e-1167.8
NC_016109:3525588:353665335366533537087435Kitasatospora setae KM-6054, complete genomeputative large-conductance mechanosensitive channel2e-1167.8
NC_014834:3472000:348881234888123489222411Rhodopseudomonas palustris DX-1 chromosome, complete genomelarge conductance mechanosensitive channel protein2e-1167.8
NC_015978:352478:372607372607372981375Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completeLarge-conductance mechanosensitive channel3e-1167.4
NC_010572:3363830:341006134100613410528468Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative large-conductance mechanosensitive channel protein8e-1165.9
NC_015957:639774:653343653343653771429Streptomyces violaceusniger Tu 4113 chromosome, complete genomelarge conductance mechanosensitive channel protein9e-1165.9
NC_017080:50000:579395793958397459Phycisphaera mikurensis NBRC 102666, complete genomelarge-conductance mechanosensitive channel1e-1065.5
NC_009348:1064664:106628510662851066692408Aeromonas salmonicida subsp. salmonicida A449, complete genomelarge-conductance mechanosensitive channel2e-1064.7
NC_015914:621411:623555623555623974420Cyclobacterium marinum DSM 745 chromosome, complete genomeLarge-conductance mechanosensitive channel3e-1063.9
NC_016776:5174606:521132052113205211742423Bacteroides fragilis 638R, complete genomeputative large-conductance mechanosensitive channel7e-1062.8
NC_021064:1789980:181195818119581812326369Propionibacterium avidum 44067, complete genomelarge conductance mechanosensitive channel8e-1062.8
NC_003902:3666544:373690137369013737332432Xanthomonas campestris pv. campestris str. ATCC 33913, completelarge-conductance mechanosensitive channel9e-1062.4
NC_018867:1161648:116164811616481162052405Dehalobacter sp. CF chromosome, complete genomeLarge-conductance mechanosensitive channel9e-1062.4
NC_015389:905165:922842922842923309468Coriobacterium glomerans PW2 chromosome, complete genomelarge conductance mechanosensitive channel protein4e-0960.5
NC_008529:264000:266698266698267174477Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeLarge-conductance mechanosensitive channel4e-0960.1
NC_011146:1429836:143905414390541439458405Geobacter bemidjiensis Bem, complete genomelarge conductance mechanosensitive channel protein8e-0959.3
NC_011027:1024995:104691910469191047374456Chlorobaculum parvum NCIB 8327, complete genomelarge conductance mechanosensitive channel protein1e-0858.9
NC_008278:81866:980189801898413396Frankia alni ACN14a, complete genomemechanosensitive channel1e-0858.5
NC_012856:3000839:301706730170673017495429Ralstonia pickettii 12D chromosome 1, complete genomelarge conductance mechanosensitive channel protein1e-0858.5
NC_014150:648868:651967651967652431465Brachyspira murdochii DSM 12563 chromosome, complete genomelarge conductance mechanosensitive channel protein1e-0858.5
NC_005945:4473790:447379044737904474188399Bacillus anthracis str. Sterne, complete genomelarge conductance mechanosensitive channel protein2e-0858.5
NC_010682:3313944:335562233556223356050429Ralstonia pickettii 12J chromosome 1, complete sequencelarge conductance mechanosensitive channel protein4e-0857
NC_014307:533975:537543537543537968426Ralstonia solanacearum CFBP2957 chromosome, complete genomelarge-conductance mechanosensitive channel7e-0856.2
NC_014935:1668461:169005016900501690484435Nitratifractor saLSUginis DSM 16511 chromosome, complete genomelarge conductance mechanosensitive channel protein9e-0855.8
NC_014718:232832:257083257083257559477Burkholderia rhizoxinica HKI 454 chromosome, complete genomeLarge-conductance mechanosensitive channel2e-0754.7
NC_006511:3364448:338767633876763388089414Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCClarge-conductance mechanosensitive channel2e-0754.7
NC_010002:6104500:610880961088096109237429Delftia acidovorans SPH-1, complete genomelarge conductance mechanosensitive channel protein2e-0754.3
NC_015563:1240978:125643412564341256862429Delftia sp. Cs1-4 chromosome, complete genomelarge conductance mechanosensitive channel protein2e-0754.3
NC_013222:2595315:261570126157012616135435Robiginitalea biformata HTCC2501, complete genomelarge conductance mechanosensitive channel protein6e-0753.1
NC_010814:155834:163539163539163982444Geobacter lovleyi SZ, complete genomelarge conductance mechanosensitive channel protein6e-0753.1
NC_010162:9727465:973099097309909731439450Sorangium cellulosum 'So ce 56', complete genomelarge conductance mechanosensitive channel7e-0752.8
NC_002678:4618555:462994646299464630367422Mesorhizobium loti MAFF303099, complete genome2e-0651.2
NC_014323:4619344:464673646467364647173438Herbaspirillum seropedicae SmR1 chromosome, complete genomelarge conductance mechanosensitive channel protein4e-0650.4