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Query: NC_009525:830513 Mycobacterium tuberculosis H37Ra, complete genome

Start: 830513, End: 849219, Length: 18707

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009565:83307683307685178218707Mycobacterium tuberculosis F11, complete genome011910BLASTN svgBLASTP svg
NC_002755:83139783139785005418658Mycobacterium tuberculosis CDC1551, complete genome011900BLASTN svgBLASTP svg
NC_002945:83102983102985365622628Mycobacterium bovis AF2122/97, complete genome011890BLASTN svgBLASTP svg
NC_012207:83103083103085360922580Mycobacterium bovis BCG str. Tokyo 172, complete genome011880BLASTN svgBLASTP svg
NC_008769:86067086067087969619027Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome011880BLASTN svgBLASTP svg
NC_008595:25466962546696258480338108Mycobacterium avium 104, complete genome01281BLASTN svgBLASTP svg
NC_015848:38512303851230387671725488Mycobacterium canettii CIPT 140010059, complete genome5e-66260BLASTN svgBLASTP svg
NC_019950:3139865*3139865316350123637Mycobacterium canettii CIPT 140060008 complete genome3e-30141BLASTN svgBLASTP svg
NC_015848:31756923175692319911823427Mycobacterium canettii CIPT 140010059, complete genome3e-30141BLASTN svgBLASTP svg
NC_004463:23441282344128236509920972Bradyrhizobium japonicum USDA 110, complete genome1e-23119BLASTN svgBLASTP svg
NC_015556:819503*81950384290123399Pseudomonas fulva 12-X chromosome, complete genome2e-22115BLASTN svgBLASTP svg
NC_005085:14980001498000152157823579Chromobacterium violaceum ATCC 12472, complete genome2e-19105BLASTN svgBLASTP svg
NC_020133:50205005020500504274122242Mycobacterium liflandii 128FXT, complete genome2e-1591.7BLASTN svgBLASTP svg
NC_021150:13220001322000135715735158Azotobacter vinelandii CA6, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_012560:13220001322000135714535146Azotobacter vinelandii DJ, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_011004:4183993*4183993422629442302Rhodopseudomonas palustris TIE-1, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_010612:54030005403000542141218413Mycobacterium marinum M, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_015677:285896*28589630970623811Ramlibacter tataouinensis TTB310 chromosome, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_012803:1552122*1552122157996027839Micrococcus luteus NCTC 2665, complete genome2e-1281.8BLASTN svgBLASTP svg
NC_012803:1094679*1094679111581321135Micrococcus luteus NCTC 2665, complete genome2e-1281.8BLASTN svgBLASTP svg
NC_013757:28583272858327287756419238Geodermatophilus obscurus DSM 43160, complete genome9e-1279.8BLASTN svgBLASTP svg
NC_010612:61131556113155613265419500Mycobacterium marinum M, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_020133:57106615710661573224421584Mycobacterium liflandii 128FXT, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_020133:14439341443934146609922166Mycobacterium liflandii 128FXT, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_000962:37815013781501380757326073Mycobacterium tuberculosis H37Rv, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_002755:37737343773734379844824715Mycobacterium tuberculosis CDC1551, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_002945:37351413735141376077425634Mycobacterium bovis AF2122/97, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_008769:37690653769065379470125637Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_009525:37940003794000381625122252Mycobacterium tuberculosis H37Ra, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_009565:37939763793976381869024715Mycobacterium tuberculosis F11, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_012207:37669783766978379261425637Mycobacterium bovis BCG str. Tokyo 172, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_020133:24219652421965244809926135Mycobacterium liflandii 128FXT, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_008027:71350071350073434320844Pseudomonas entomophila L48, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_003143:28956172895617291809922483Yersinia pestis CO92, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_004088:12917541291754131420722454Yersinia pestis KIM, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_008149:12216371221637124331521679Yersinia pestis Nepal516, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_011892:35265235265237609923448Methylobacterium nodulans ORS 2060 plasmid pMNOD01, complete9e-0969.9BLASTN svgBLASTP svg
NC_007963:26449302644930268018935260Chromohalobacter salexigens DSM 3043, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_016002:2946702*2946702299376147060Pseudogulbenkiania sp. NH8B, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_010002:40385004038500406476326264Delftia acidovorans SPH-1, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_019974:30838993083899310618822290Natronococcus occultus SP4, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_015711:19141621914162193395819797Myxococcus fulvus HW-1 chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_015848:16475231647523167029122769Mycobacterium canettii CIPT 140010059, complete genome9e-0660BLASTN svgBLASTP svg
NC_009565:16297801629780165615326374Mycobacterium tuberculosis F11, complete genome9e-0660BLASTN svgBLASTP svg
NC_002945:16217651621765164826226498Mycobacterium bovis AF2122/97, complete genome9e-0660BLASTN svgBLASTP svg