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Query: NC_009525:477093 Mycobacterium tuberculosis H37Ra, complete genome

Start: 477093, End: 500929, Length: 23837

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_000962:47581647581649961923804Mycobacterium tuberculosis H37Rv, complete genome047150BLASTN svgBLASTP svg
NC_002945:47683547683550063823804Mycobacterium bovis AF2122/97, complete genome047010BLASTN svgBLASTP svg
NC_008769:50700050700053043423435Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome046280BLASTN svgBLASTP svg
NC_009565:47950047950050278923290Mycobacterium tuberculosis F11, complete genome046110BLASTN svgBLASTP svg
NC_012207:47750047750050076723268Mycobacterium bovis BCG str. Tokyo 172, complete genome045950BLASTN svgBLASTP svg
NC_019950:48188148188150600724127Mycobacterium canettii CIPT 140060008 complete genome028960BLASTN svgBLASTP svg
NC_015848:48350048350050998826489Mycobacterium canettii CIPT 140010059, complete genome024450BLASTN svgBLASTP svg
NC_002755:47287247287249645723586Mycobacterium tuberculosis CDC1551, complete genome023200BLASTN svgBLASTP svg
NC_010612:83564883564886299927352Mycobacterium marinum M, complete genome01822BLASTN svgBLASTP svg
NC_002677:36343236343238893225501Mycobacterium leprae TN, complete genome01179BLASTN svgBLASTP svg
NC_011896:36344836344838894925502Mycobacterium leprae Br4923, complete genome01179BLASTN svgBLASTP svg
NC_011896:332939*33293935403321095Mycobacterium leprae Br4923, complete genome5e-162579BLASTN svgBLASTP svg
NC_002677:332923*33292335401721095Mycobacterium leprae TN, complete genome5e-162579BLASTN svgBLASTP svg
NC_012522:2031786*2031786206157229787Rhodococcus opacus B4, complete genome3e-46194BLASTN svgBLASTP svg
NC_013159:1807599*1807599183475127153Saccharomonospora viridis DSM 43017, complete genome4e-30141BLASTN svgBLASTP svg
NC_008268:2313583*2313583234448830906Rhodococcus sp. RHA1, complete genome1e-29139BLASTN svgBLASTP svg
NC_008271:35909359096246126553Rhodococcus sp. RHA1 plasmid pRHL3, complete sequence1e-29139BLASTN svgBLASTP svg
NC_000962:32884643288464331029721834Mycobacterium tuberculosis H37Rv, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_002755:32827853282785330371920935Mycobacterium tuberculosis CDC1551, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_002945:32462783246278326609919822Mycobacterium bovis AF2122/97, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_008769:32424533242453326356021108Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_009525:33004563300456332228921834Mycobacterium tuberculosis H37Ra, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_009565:32999373299937332177021834Mycobacterium tuberculosis F11, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_012207:32374403237440325728519846Mycobacterium bovis BCG str. Tokyo 172, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_015848:33437313343731336691823188Mycobacterium canettii CIPT 140010059, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_019950:33064193306419333122724809Mycobacterium canettii CIPT 140060008 complete genome5e-1487.7BLASTN svgBLASTP svg
NC_010694:13242501324250134559221343Erwinia tasmaniensis, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_008271:14084614084616654625701Rhodococcus sp. RHA1 plasmid pRHL3, complete sequence7e-1073.8BLASTN svgBLASTP svg
NC_010612:3745332*3745332378131835987Mycobacterium marinum M, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010397:43875004387500440592818429Mycobacterium abscessus chromosome Chromosome, complete sequence1e-0869.9BLASTN svgBLASTP svg
NC_013595:9994000*99940001001201918020Streptosporangium roseum DSM 43021, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_015957:61193466119346619590076555Streptomyces violaceusniger Tu 4113 chromosome, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_011770:49241274924127497209947973Pseudomonas aeruginosa LESB58, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_002944:18814051881405190464023236Mycobacterium avium subsp. paratuberculosis K-10, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_002516:89100089100091357122572Pseudomonas aeruginosa PAO1, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_000962:18708421870842189534224501Mycobacterium tuberculosis H37Rv, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_002755:18596301859630187892619297Mycobacterium tuberculosis CDC1551, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_002944:12854361285436132132435889Mycobacterium avium subsp. paratuberculosis K-10, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_002945:18562281856228188073824511Mycobacterium bovis AF2122/97, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_008769:18761091876109190061624508Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_009525:18723601872360189686024501Mycobacterium tuberculosis H37Ra, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_009565:18662141866214189074224529Mycobacterium tuberculosis F11, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_012207:18480911848091186924521155Mycobacterium bovis BCG str. Tokyo 172, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_015848:18966601896660192209125432Mycobacterium canettii CIPT 140010059, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_019950:18708631870863189629425432Mycobacterium canettii CIPT 140060008 complete genome7e-0763.9BLASTN svgBLASTP svg
NC_018681:1021063*1021063104680525743Nocardia brasiliensis ATCC 700358 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_015859:10691161069116109541926304Corynebacterium variabile DSM 44702 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_014831:86661486661489112124508Thermaerobacter marianensis DSM 12885 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg