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Query: NC_009525:3794000 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3794000, End: 3816251, Length: 22252

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_000962:37815013781501380757326073Mycobacterium tuberculosis H37Rv, complete genome034130BLASTN svgBLASTP svg
NC_009565:37939763793976381869024715Mycobacterium tuberculosis F11, complete genome020170BLASTN svgBLASTP svg
NC_002755:37737343773734379844824715Mycobacterium tuberculosis CDC1551, complete genome020150BLASTN svgBLASTP svg
NC_002945:37351413735141376077425634Mycobacterium bovis AF2122/97, complete genome020100BLASTN svgBLASTP svg
NC_012207:37669783766978379261425637Mycobacterium bovis BCG str. Tokyo 172, complete genome020090BLASTN svgBLASTP svg
NC_008769:37690653769065379470125637Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome020090BLASTN svgBLASTP svg
NC_019950:38180003818000384014722148Mycobacterium canettii CIPT 140060008 complete genome019930BLASTN svgBLASTP svg
NC_015848:38512303851230387671725488Mycobacterium canettii CIPT 140010059, complete genome019560BLASTN svgBLASTP svg
NC_009525:2635792*2635792265864122850Mycobacterium tuberculosis H37Ra, complete genome02688BLASTN svgBLASTP svg
NC_000962:31168183116818313633319516Mycobacterium tuberculosis H37Rv, complete genome02686BLASTN svgBLASTP svg
NC_002755:31109293110929312975718829Mycobacterium tuberculosis CDC1551, complete genome02686BLASTN svgBLASTP svg
NC_002945:30733703073370309459921230Mycobacterium bovis AF2122/97, complete genome02686BLASTN svgBLASTP svg
NC_008769:30702663070266308959919334Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome02686BLASTN svgBLASTP svg
NC_009525:31287863128786314904720262Mycobacterium tuberculosis H37Ra, complete genome02686BLASTN svgBLASTP svg
NC_009565:31280943128094314823720144Mycobacterium tuberculosis F11, complete genome02686BLASTN svgBLASTP svg
NC_009565:34857723485772350477419003Mycobacterium tuberculosis F11, complete genome02686BLASTN svgBLASTP svg
NC_012207:30630393063039308477921741Mycobacterium bovis BCG str. Tokyo 172, complete genome02686BLASTN svgBLASTP svg
NC_002755:47287247287249645723586Mycobacterium tuberculosis CDC1551, complete genome02680BLASTN svgBLASTP svg
NC_009077:2308634*2308634235649847865Mycobacterium sp. JLS, complete genome0777BLASTN svgBLASTP svg
NC_002677:49104349104351327322231Mycobacterium leprae TN, complete genome8e-22113BLASTN svgBLASTP svg
NC_020133:48419324841932485992417993Mycobacterium liflandii 128FXT, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_002755:83139783139785005418658Mycobacterium tuberculosis CDC1551, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_002945:83102983102985365622628Mycobacterium bovis AF2122/97, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_008769:86067086067087969619027Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_009525:83051383051384921918707Mycobacterium tuberculosis H37Ra, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_009565:83307683307685178218707Mycobacterium tuberculosis F11, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_012207:83103083103085360922580Mycobacterium bovis BCG str. Tokyo 172, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_020133:14439341443934146609922166Mycobacterium liflandii 128FXT, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_008435:1215437*1215437131209196655Rhodopseudomonas palustris BisA53, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_013235:13544431354443137485420412Nakamurella multipartita DSM 44233, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_013235:3812838*3812838384142328586Nakamurella multipartita DSM 44233, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_014815:841484*84148489809956616Micromonospora sp. L5 chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_014814:2588628*2588628264757658949Mycobacterium sp. Spyr1 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_009525:39335673933567395892925363Mycobacterium tuberculosis H37Ra, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_008752:32176953217695323954921855Acidovorax avenae subsp. citrulli AAC00-1, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_008752:29369332936933297832941397Acidovorax avenae subsp. citrulli AAC00-1, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_010125:10517351051735108259930865Gluconacetobacter diazotrophicus PAl 5, complete genome7e-0763.9BLASTN svgBLASTP svg