Pre_GI: BLASTN Hits

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Query: NC_009525:3300456 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3300456, End: 3322289, Length: 21834

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_000962:32884643288464331029721834Mycobacterium tuberculosis H37Rv, complete genome043240BLASTN svgBLASTP svg
NC_009565:32999373299937332177021834Mycobacterium tuberculosis F11, complete genome043230BLASTN svgBLASTP svg
NC_002755:32827853282785330371920935Mycobacterium tuberculosis CDC1551, complete genome041410BLASTN svgBLASTP svg
NC_012207:32374403237440325728519846Mycobacterium bovis BCG str. Tokyo 172, complete genome037320BLASTN svgBLASTP svg
NC_019950:33064193306419333122724809Mycobacterium canettii CIPT 140060008 complete genome037040BLASTN svgBLASTP svg
NC_015848:33437313343731336691823188Mycobacterium canettii CIPT 140010059, complete genome037040BLASTN svgBLASTP svg
NC_002945:32462783246278326609919822Mycobacterium bovis AF2122/97, complete genome035560BLASTN svgBLASTP svg
NC_008769:32424533242453326356021108Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome035540BLASTN svgBLASTP svg
NC_002677:17317017317019196118792Mycobacterium leprae TN, complete genome01429BLASTN svgBLASTP svg
NC_011896:17319717319719198818792Mycobacterium leprae Br4923, complete genome01429BLASTN svgBLASTP svg
NC_010612:103081*10308113565632576Mycobacterium marinum M, complete genome5e-91343BLASTN svgBLASTP svg
NC_020133:77341773419927021930Mycobacterium liflandii 128FXT, complete genome1e-88335BLASTN svgBLASTP svg
NC_010612:46795944679594471951939926Mycobacterium marinum M, complete genome5e-51210BLASTN svgBLASTP svg
NC_010612:3745332*3745332378131835987Mycobacterium marinum M, complete genome2e-44188BLASTN svgBLASTP svg
NC_020133:2886541*2886541291380027260Mycobacterium liflandii 128FXT, complete genome2e-44188BLASTN svgBLASTP svg
NC_008611:2615204*2615204263604620843Mycobacterium ulcerans Agy99, complete genome4e-42180BLASTN svgBLASTP svg
NC_009142:827912*82791284912621215Saccharopolyspora erythraea NRRL 2338, complete genome6e-38167BLASTN svgBLASTP svg
NC_009142:28015172801517283231830802Saccharopolyspora erythraea NRRL 2338, complete genome6e-35157BLASTN svgBLASTP svg
NC_003155:11378171137817120257364757Streptomyces avermitilis MA-4680, complete genome6e-35157BLASTN svgBLASTP svg
NC_010572:73042907304290735268448395Streptomyces griseus subsp. griseus NBRC 13350, complete genome9e-34153BLASTN svgBLASTP svg
NC_019950:18708631870863189629425432Mycobacterium canettii CIPT 140060008 complete genome9e-31143BLASTN svgBLASTP svg
NC_015848:18966601896660192209125432Mycobacterium canettii CIPT 140010059, complete genome9e-31143BLASTN svgBLASTP svg
NC_012207:18480911848091186924521155Mycobacterium bovis BCG str. Tokyo 172, complete genome9e-31143BLASTN svgBLASTP svg
NC_009565:18662141866214189074224529Mycobacterium tuberculosis F11, complete genome9e-31143BLASTN svgBLASTP svg
NC_009525:18723601872360189686024501Mycobacterium tuberculosis H37Ra, complete genome9e-31143BLASTN svgBLASTP svg
NC_008769:18761091876109190061624508Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome9e-31143BLASTN svgBLASTP svg
NC_002945:18562281856228188073824511Mycobacterium bovis AF2122/97, complete genome9e-31143BLASTN svgBLASTP svg
NC_002755:18596301859630187892619297Mycobacterium tuberculosis CDC1551, complete genome9e-31143BLASTN svgBLASTP svg
NC_000962:18708421870842189534224501Mycobacterium tuberculosis H37Rv, complete genome9e-31143BLASTN svgBLASTP svg
NC_009565:2306574*2306574233169725124Mycobacterium tuberculosis F11, complete genome5e-29137BLASTN svgBLASTP svg
NC_015434:5411*54112875223342Verrucosispora maris AB-18-032 chromosome, complete genome1e-26129BLASTN svgBLASTP svg
NC_015434:24600532460053249159931547Verrucosispora maris AB-18-032 chromosome, complete genome5e-26127BLASTN svgBLASTP svg
NC_015957:45464034546403458592939527Streptomyces violaceusniger Tu 4113 chromosome, complete genome1e-23119BLASTN svgBLASTP svg
NC_019950:16899101689910171687926970Mycobacterium canettii CIPT 140060008 complete genome5e-20107BLASTN svgBLASTP svg
NC_015957:61193466119346619590076555Streptomyces violaceusniger Tu 4113 chromosome, complete genome5e-20107BLASTN svgBLASTP svg
NC_015957:42928194292819431625023432Streptomyces violaceusniger Tu 4113 chromosome, complete genome5e-20107BLASTN svgBLASTP svg
NC_015848:17081761708176173271724542Mycobacterium canettii CIPT 140010059, complete genome5e-20107BLASTN svgBLASTP svg
NC_009142:45718894571889461144339555Saccharopolyspora erythraea NRRL 2338, complete genome8e-19103BLASTN svgBLASTP svg
NC_015953:58657335865733590682141089Streptomyces sp. SirexAA-E chromosome, complete genome8e-19103BLASTN svgBLASTP svg
NC_013093:30684863068486311387545390Actinosynnema mirum DSM 43827, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_009565:16886421688642171216323522Mycobacterium tuberculosis F11, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_009525:16855221685522171115225631Mycobacterium tuberculosis H37Ra, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_002755:16841611684161170880524645Mycobacterium tuberculosis CDC1551, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_000962:16840051684005170853924535Mycobacterium tuberculosis H37Rv, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_015957:60295426029542605506325522Streptomyces violaceusniger Tu 4113 chromosome, complete genome5e-1797.6BLASTN svgBLASTP svg
NC_002677:17160001716000173800622007Mycobacterium leprae TN, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_011896:17160001716000173793921940Mycobacterium leprae Br4923, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_002944:12854361285436132132435889Mycobacterium avium subsp. paratuberculosis K-10, complete genome7e-1693.7BLASTN svgBLASTP svg
NC_000962:47581647581649961923804Mycobacterium tuberculosis H37Rv, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_002755:47287247287249645723586Mycobacterium tuberculosis CDC1551, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_002945:47683547683550063823804Mycobacterium bovis AF2122/97, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_008769:50700050700053043423435Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_009525:47709347709350092923837Mycobacterium tuberculosis H37Ra, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_009565:47950047950050278923290Mycobacterium tuberculosis F11, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_012207:47750047750050076723268Mycobacterium bovis BCG str. Tokyo 172, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_015848:48350048350050998826489Mycobacterium canettii CIPT 140010059, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_019950:48188148188150600724127Mycobacterium canettii CIPT 140060008 complete genome4e-1487.7BLASTN svgBLASTP svg
NC_009077:2308634*2308634235649847865Mycobacterium sp. JLS, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_014391:26513152651315269455543241Micromonospora aurantiaca ATCC 27029 chromosome, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_015145:10452641045264108425238989Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_009921:57874375787437580894021504Frankia sp. EAN1pec, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_018583:953889538813461139224Gordonia sp. KTR9 plasmid pGKT3, complete sequence4e-1177.8BLASTN svgBLASTP svg
NC_004578:52691945269194529610426911Pseudomonas syringae pv. tomato str. DC3000, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_010612:83564883564886299927352Mycobacterium marinum M, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_015957:45255804525580455677331194Streptomyces violaceusniger Tu 4113 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_010572:75861157586115761955133437Streptomyces griseus subsp. griseus NBRC 13350, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_008278:2772726*2772726280322330498Frankia alni ACN14a, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_002945:16807511680751170398323233Mycobacterium bovis AF2122/97, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_008769:17090781709078173231123234Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_012207:16819711681971170520423234Mycobacterium bovis BCG str. Tokyo 172, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_013947:44133824413382443709923718Stackebrandtia nassauensis DSM 44728 chromosome, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_015312:63989316398931641727718347Pseudonocardia dioxanivorans CB1190 chromosome, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_015588:18475001847500187818330684Isoptericola variabilis 225 chromosome, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_013530:28195692819569285198132413Xylanimonas cellulosilytica DSM 15894, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_020126:6344827*6344827637873333907Myxococcus stipitatus DSM 14675, complete genome3e-0661.9BLASTN svgBLASTP svg