Query: NC_009525:1096386 Mycobacterium tuberculosis H37Ra, complete genome
Start: 1096386, End: 1118456, Length: 22071
Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Start | End | Length | Subject Host Description | E-value | Bit score | Visual BLASTN | Visual BLASTP |
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NC_002945:1095337* | 1095337 | 1117599 | 22263 | Mycobacterium bovis AF2122/97, complete genome | 0 | 41590 | BLASTN svg | BLASTP svg |
NC_008769:1125567* | 1125567 | 1147637 | 22071 | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome | 0 | 41580 | BLASTN svg | BLASTP svg |
NC_009565:1098847* | 1098847 | 1120293 | 21447 | Mycobacterium tuberculosis F11, complete genome | 0 | 40380 | BLASTN svg | BLASTP svg |
NC_015848:1105892* | 1105892 | 1127326 | 21435 | Mycobacterium canettii CIPT 140010059, complete genome | 0 | 39920 | BLASTN svg | BLASTP svg |
NC_000962:1095078* | 1095078 | 1115749 | 20672 | Mycobacterium tuberculosis H37Rv, complete genome | 0 | 38970 | BLASTN svg | BLASTP svg |
NC_012207:1097228* | 1097228 | 1117899 | 20672 | Mycobacterium bovis BCG str. Tokyo 172, complete genome | 0 | 38810 | BLASTN svg | BLASTP svg |
NC_002755:1095105* | 1095105 | 1115787 | 20683 | Mycobacterium tuberculosis CDC1551, complete genome | 0 | 38720 | BLASTN svg | BLASTP svg |
NC_010397:1099312* | 1099312 | 1122647 | 23336 | Mycobacterium abscessus chromosome Chromosome, complete sequence | 1e-36 | 163 | BLASTN svg | BLASTP svg |
NC_006361:5146000* | 5146000 | 5173599 | 27600 | Nocardia farcinica IFM 10152, complete genome | 4e-36 | 161 | BLASTN svg | BLASTP svg |
NC_013159:3554389* | 3554389 | 3573622 | 19234 | Saccharomonospora viridis DSM 43017, complete genome | 9e-31 | 143 | BLASTN svg | BLASTP svg |
NC_013441:1487058 | 1487058 | 1517691 | 30634 | Gordonia bronchialis DSM 43247, complete genome | 9e-31 | 143 | BLASTN svg | BLASTP svg |
NC_010407:32960* | 32960 | 51633 | 18674 | Clavibacter michiganensis subsp. sepedonicus chromosome, complete | 2e-19 | 105 | BLASTN svg | BLASTP svg |
NC_008699:833737* | 833737 | 856640 | 22904 | Nocardioides sp. JS614, complete genome | 2e-19 | 105 | BLASTN svg | BLASTP svg |
NC_014215:1929000* | 1929000 | 1947146 | 18147 | Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, | 8e-19 | 103 | BLASTN svg | BLASTP svg |
NC_015312:848403* | 848403 | 867717 | 19315 | Pseudonocardia dioxanivorans CB1190 chromosome, complete genome | 3e-18 | 101 | BLASTN svg | BLASTP svg |
NC_021064:1789980* | 1789980 | 1812326 | 22347 | Propionibacterium avidum 44067, complete genome | 5e-14 | 87.7 | BLASTN svg | BLASTP svg |
NC_018524:444217* | 444217 | 474099 | 29883 | Nocardiopsis alba ATCC BAA-2165 chromosome, complete genome | 2e-13 | 85.7 | BLASTN svg | BLASTP svg |
NC_013510:1786194* | 1786194 | 1813698 | 27505 | Thermomonospora curvata DSM 43183, complete genome | 2e-13 | 85.7 | BLASTN svg | BLASTP svg |
NC_015635:3860570* | 3860570 | 3891855 | 31286 | Microlunatus phosphovorus NM-1, complete genome | 7e-13 | 83.8 | BLASTN svg | BLASTP svg |
NC_007777:75885 | 75885 | 98099 | 22215 | Frankia sp. CcI3, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_010612:5403000 | 5403000 | 5421412 | 18413 | Mycobacterium marinum M, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_020133:5020500 | 5020500 | 5042741 | 22242 | Mycobacterium liflandii 128FXT, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_015138:1143015 | 1143015 | 1165430 | 22416 | Acidovorax avenae subsp. avenae ATCC 19860 chromosome, complete | 2e-10 | 75.8 | BLASTN svg | BLASTP svg |
NC_014168:471000* | 471000 | 494251 | 23252 | Segniliparus rotundus DSM 44985 chromosome, complete genome | 2e-10 | 75.8 | BLASTN svg | BLASTP svg |
NC_008618:10915* | 10915 | 35645 | 24731 | Bifidobacterium adolescentis ATCC 15703, complete genome | 2e-10 | 75.8 | BLASTN svg | BLASTP svg |
NC_020302:2219378 | 2219378 | 2246099 | 26722 | Corynebacterium halotolerans YIM 70093 = DSM 44683, complete | 7e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_008268:5781604* | 5781604 | 5814244 | 32641 | Rhodococcus sp. RHA1, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_011992:773905 | 773905 | 797509 | 23605 | Acidovorax ebreus TPSY, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_012803:1094679* | 1094679 | 1115813 | 21135 | Micrococcus luteus NCTC 2665, complete genome | 1e-08 | 69.9 | BLASTN svg | BLASTP svg |
NC_013174:23421* | 23421 | 61987 | 38567 | Jonesia denitrificans DSM 20603, complete genome | 4e-08 | 67.9 | BLASTN svg | BLASTP svg |
NC_005835:1345790* | 1345790 | 1369527 | 23738 | Thermus thermophilus HB27, complete genome | 2e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_006177:280234* | 280234 | 319207 | 38974 | Symbiobacterium thermophilum IAM 14863, complete genome | 2e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_006177:835459* | 835459 | 858835 | 23377 | Symbiobacterium thermophilum IAM 14863, complete genome | 2e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_014814:3926676* | 3926676 | 3948945 | 22270 | Mycobacterium sp. Spyr1 chromosome, complete genome | 2e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_014958:843456* | 843456 | 869437 | 25982 | Deinococcus maricopensis DSM 21211 chromosome, complete genome | 7e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_008278:81866* | 81866 | 102166 | 20301 | Frankia alni ACN14a, complete genome | 7e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_008148:3024867 | 3024867 | 3046715 | 21849 | Rubrobacter xylanophilus DSM 9941, complete genome | 7e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_015677:3339181* | 3339181 | 3363881 | 24701 | Ramlibacter tataouinensis TTB310 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_014323:4619344* | 4619344 | 4652417 | 33074 | Herbaspirillum seropedicae SmR1 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_014318:7821227* | 7821227 | 7859599 | 38373 | Amycolatopsis mediterranei U32 chromosome, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_002936:1395432* | 1395432 | 1419062 | 23631 | Dehalococcoides ethenogenes 195, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |