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Query: NC_009525:3794000:3810668 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3810668, End: 3813469, Length: 2802

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3754000:377317537731753774047873Mycobacterium tuberculosis RGTB327 chromosome, complete genomedehydrogenase1e-136487
NC_008769:3769065:379018337901833791055873Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative dehydrogenase1e-136487
NC_012207:3766978:378809637880963788968873Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative dehydrogenase1e-136487
NC_000962:3781501:380391938039193804791873Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE DEHYDROGENASE1e-136487
NC_009565:3793976:381503638150363815908873Mycobacterium tuberculosis F11, complete genomehypothetical dehydrogenase1e-136487
NC_002755:3773734:379479437947943795666873Mycobacterium tuberculosis CDC1551, complete genomeMaoC family protein1e-136487
NC_012943:3777371:379843137984313799303873Mycobacterium tuberculosis KZN 1435 chromosome, complete genomedehydrogenase1e-136487
NC_016768:3774105:379516537951653796037873Mycobacterium tuberculosis KZN 4207 chromosome, complete genomedehydrogenase1e-136487
NC_016804:3753243:376954837695483770420873Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative dehydrogenase1e-136487
NC_019950:3818000:383172238317223832594873Mycobacterium canettii CIPT 140060008 complete genomeDouble hotdog hydratase5e-136486
NC_002945:3735141:375625637562563757128873Mycobacterium bovis AF2122/97, complete genomedehydrogenase1e-135484
NC_015848:3851230:387124938712493872121873Mycobacterium canettii CIPT 140010059, complete genomeputative dehydrogenase3e-133476
NC_016887:511034:526243526243527106864Nocardia cyriacigeorgica GUH-2, complete genomeputative 3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase6e-33143
NC_008705:4975402:497997449799744980834861Mycobacterium sp. KMS, complete genomeMaoC domain protein dehydratase5e-31137
NC_009077:5286275:528882852888285289688861Mycobacterium sp. JLS, complete genomeMaoC domain protein dehydratase5e-31137
NC_008146:4936262:494083449408344941694861Mycobacterium sp. MCS, complete genomeMaoC-like dehydratase5e-31137
NC_007974:2097334:211973321197332120608876Ralstonia metallidurans CH34 chromosome 2, complete sequenceMaoC-like dehydratase4e-30134
NC_018080:4436646:443808344380834438949867Pseudomonas aeruginosa DK2 chromosome, complete genomehypothetical protein6e-29130
NC_010512:951527:953536953536954405870Burkholderia cenocepacia MC0-3 chromosome 3, complete sequence3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoAhydratase3e-26121
NC_014218:1485568:149813514981351499010876Arcanobacterium haemolyticum DSM 20595 chromosome, complete genome3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase3e-1791.3
NC_021171:4588792:459373045937304594581852Bacillus sp. 1NLA3E, complete genomedehydratase4e-1687.8
NC_015738:1925997:194170519417051942577873Eggerthella sp. YY7918, complete genomeputative acyl dehydratase6e-1377
NC_016887:1093609:111781911178191118694876Nocardia cyriacigeorgica GUH-2, complete genomeputative dehydratase8e-0963.2