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Query: NC_009525:3794000:3808758 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3808758, End: 3809066, Length: 309

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3754000:376889137688913769199309Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein3e-41166
NC_012207:3766978:378375537837553784063309Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein3e-41166
NC_008769:3769065:378584237858423786150309Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein3e-41166
NC_000962:3781501:379963537996353799943309Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein3e-41166
NC_009565:3793976:381075238107523811060309Mycobacterium tuberculosis F11, complete genomehypothetical protein3e-41166
NC_002945:3735141:375191837519183752226309Mycobacterium bovis AF2122/97, complete genomehypothetical protein3e-41166
NC_002755:3773734:379051037905103790818309Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein3e-41166
NC_012943:3777371:379414737941473794455309Mycobacterium tuberculosis KZN 1435 chromosome, complete genomeantitoxin3e-41166
NC_016768:3774105:379088137908813791189309Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein3e-41166
NC_016804:3753243:376520737652073765515309Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein3e-41166
NC_015848:3851230:386941438694143869692279Mycobacterium canettii CIPT 140010059, complete genomeantitoxin3e-31133
NC_019950:3818000:383139938313993831677279Mycobacterium canettii CIPT 140060008 complete genomeConserved protein of unknown function, putative antitoxin3e-31133
NC_015656:4850833:486078948607894861085297Frankia symbiont of Datisca glomerata chromosome, complete genomeprevent-host-death family protein1e-0651.6
NC_008278:613329:613329613329613592264Frankia alni ACN14a, complete genomehypothetical protein5e-0649.7