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Query: NC_009525:3794000:3799971 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3799971, End: 3801476, Length: 1506

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3754000:3760100376010037616051506Mycobacterium tuberculosis RGTB327 chromosome, complete genomecyclase01035
NC_016768:3774105:3783452378345237849571506Mycobacterium tuberculosis KZN 4207 chromosome, complete genomecyclase01035
NC_012943:3777371:3786718378671837882231506Mycobacterium tuberculosis KZN 1435 chromosome, complete genomecyclase01035
NC_009565:3793976:3803323380332338048281506Mycobacterium tuberculosis F11, complete genomehypothetical cyclase01035
NC_000962:3781501:3790848379084837923531506Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE CYCLASE01035
NC_002755:3773734:3783081378308137845861506Mycobacterium tuberculosis CDC1551, complete genomecyclase, putative01034
NC_015848:3851230:3860577386057738620821506Mycobacterium canettii CIPT 140010059, complete genomeputative cyclase01029
NC_019950:3818000:3823968382396838254731506Mycobacterium canettii CIPT 140060008 complete genomeHalimadienyl diphosphate synthase (type-B diterpene cyclase)01029
NC_016804:3753243:3757830375783037592811452Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative cyclase0842
NC_002945:3735141:3744541374454137459921452Mycobacterium bovis AF2122/97, complete genomecyclase0842
NC_008769:3769065:3778465377846537799161452Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative cyclase0842
NC_012207:3766978:3776378377637837778291452Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative cyclase0842
NC_009953:1484000:1498210149821014998051596Salinispora arenicola CNS-205 chromosome, complete genomehypothetical protein3e-26120
NC_017249:7917586:7952337795233779538961560Bradyrhizobium japonicum USDA 6, complete genomehypothetical protein5e-25116
NC_010801:238430:2541422541422557041563Burkholderia multivorans ATCC 17616 chromosome 3, completehypothetical protein6e-1375.9