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Query: NC_009525:3794000:3797491 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3797491, End: 3797739, Length: 249

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:3753243:375465537546553755545891Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative enoyl-CoA hydratase9e-41165
NC_009565:3793976:380084338008433801091249Mycobacterium tuberculosis F11, complete genomeenoyl-CoA hydratase echA18.11e-40165
NC_000962:3781501:378836837883683788616249Mycobacterium tuberculosis H37Rv, complete genomePROBABLE ENOYL-CoA HYDRATASE (FRAGMENT) ECHA18.1 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)1e-40165
NC_012943:3777371:378423837842383784486249Mycobacterium tuberculosis KZN 1435 chromosome, complete genomeenoyl-CoA hydratase echA18_11e-40165
NC_016768:3774105:378097237809723781220249Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeenoyl-CoA hydratase echA18_11e-40165
NC_017026:3754000:375761937576193757867249Mycobacterium tuberculosis RGTB327 chromosome, complete genomeenoyl-CoA hydratase1e-40165
NC_002945:3735141:374136637413663742256891Mycobacterium bovis AF2122/97, complete genomeenoyl-CoA hydratase9e-41165
NC_008769:3769065:377529037752903776180891Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative enoyl-CoA hydratase echA189e-41165
NC_012207:3766978:377320337732033774093891Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative enoyl-CoA hydratase9e-41165
NC_019950:3818000:382084538208453821735891Mycobacterium canettii CIPT 140060008 complete genomeEnoyl-CoA hydratase EchA181e-40164
NC_015848:3851230:385809638580963858344249Mycobacterium canettii CIPT 140010059, complete genomeputative enoyl-CoA hydratase5e-40162