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Query: NC_009525:3484924:3489216 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3489216, End: 3489656, Length: 441

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002755:3465582:347278834727883473297510Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein2e-80296
NC_016804:3407859:341091234109123411352441Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein6e-80295
NC_008769:3427254:343154734315473431987441Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein6e-80295
NC_012207:3421144:342419734241973424637441Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein6e-80295
NC_009565:3485772:348882534888253489265441Mycobacterium tuberculosis F11, complete genomehypothetical protein6e-80295
NC_000962:3474000:347706034770603477500441Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein6e-80295
NC_002945:3429315:343360834336083434048441Mycobacterium bovis AF2122/97, complete genomehypothetical protein8e-80295
NC_002755:3465582:348749934874993487663165Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein8e-0649.3