Pre_GI: BLASTP Hits

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Query: NC_009495:3502000:3513799 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 3513799, End: 3514716, Length: 918

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:3463736:348978734897873490704918Clostridium botulinum A str. ATCC 19397 chromosome, complete8-oxoguanine DNA glycosylase4e-179627
NC_017297:3594000:360604836060483606965918Clostridium botulinum F str. 230613 chromosome, complete genomeputative 8-oxoguanine DNA glycosylase1e-178625
NC_009699:3581376:360743336074333608350918Clostridium botulinum F str. Langeland chromosome, complete genome8-oxoguanine DNA glycosylase1e-178625
NC_012563:3729817:375587337558733756790918Clostridium botulinum A2 str. Kyoto, complete genomeputative 8-oxoguanine DNA glycosylase1e-176618
NC_010520:3580000:359100235910023591919918Clostridium botulinum A3 str. Loch Maree, complete genomeputative 8-oxoguanine DNA glycosylase1e-172605
NC_008593:2136759:214821121482112149089879Clostridium novyi NT, complete genome8-oxoguanine-DNA-glycosylase, putative7e-121433
NC_015425:2389400:240477224047722405650879Clostridium botulinum BKT015925 chromosome, complete genomeputative 8-oxoguanine DNA glycosylase1e-117422
NC_014393:3650957:365590336559033656778876Clostridium cellulovorans 743B chromosome, complete genomeDNA-(apurinic or apyrimidinic site) lyase5e-112404
NC_021182:1473535:148750414875041488382879Clostridium pasteurianum BC1, complete genome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase2e-110398
NC_004557:2552418:255790725579072558842936Clostridium tetani E88, complete genome8-oxoguanine DNA glycosylase7e-107387
NC_008262:2498000:250322425032242504162939Clostridium perfringens SM101, complete genome8-oxoguanine DNA glycosylase, putative8e-105380
NC_010674:370629:386582386582387508927Clostridium botulinum B str. Eklund 17B, complete genome8-oxoguanine DNA glycosylase8e-102370
NC_010723:371741:381973381973382899927Clostridium botulinum E3 str. Alaska E43, complete genome8-oxoguanine DNA glycosylase5e-100364
NC_009617:385000:392811392811393740930Clostridium beijerinckii NCIMB 8052 chromosome, complete genome8-oxoguanine DNA glycosylase2e-99362
NC_020291:491000:508306508306509232927Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase3e-96351
NC_018664:287769:297133297133298017885Clostridium acidurici 9a chromosome, complete genome8-oxoguanine DNA glycosylase2e-81302
NC_015275:3594890:361343036134303614326897Clostridium lentocellum DSM 5427 chromosome, complete genomeDNA-(apurinic or apyrimidinic site) lyase1e-58227
NC_016630:864601:895181895181896071891Filifactor alocis ATCC 35896 chromosome, complete genome3-methyladenine DNA glycosylase1e-57223
NC_019977:1996414:201937920193792020218840Methanomethylovorans hollandica DSM 15978, complete genome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase5e-36151
NC_007955:1198994:121547612154761216315840Methanococcoides burtonii DSM 6242, complete genome8-oxoguanine DNA glycosylase-like protein1e-35150
NC_012785:20454:400804008040973894Kosmotoga olearia TBF 19.5.1, complete genome8-oxoguanine DNA glycosylase domain protein2e-32139
NC_016024:1472421:1484493148449314855511059Candidatus Chloracidobacterium thermophilum B chromosome chromosome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase3e-27122
NC_012029:1525929:152916915291691530095927Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genome8-oxoguanine DNA glycosylase domain protein1e-26120
NC_011026:2624775:263091326309132631884972Chloroherpeton thalassium ATCC 35110, complete genome8-oxoguanine DNA glycosylase domain protein5e-1995.1
NC_002932:937157:946201946201947166966Chlorobium tepidum TLS, complete genome8-oxoguanine DNA glycosylase, putative2e-1686.7